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Science 19 July 2002:
Vol. 297. no. 5580, pp. 409 - 412
DOI: 10.1126/science.1071632
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Reports

Integrin-Mediated Long-Term B Cell Retention in the Splenic Marginal Zone

Theresa T. Lu, Jason G. Cyster*

The mechanisms that control localization of marginal zone (MZ) B cells are poorly understood. Here we show that MZ B cells express elevated levels of the integrins LFA-1 (alpha Lbeta 2) and alpha 4beta 1 and that they bind to the ligands ICAM-1 and VCAM-1. These ligands are expressed within the MZ in a lymphotoxin-dependent manner. Combined inhibition of LFA-1 and alpha 4beta 1 causes a rapid and selective release of B cells from the MZ. Furthermore, lipopolysaccharide-triggered MZ B cell relocalization involves down-regulation of integrin-mediated adhesion. These studies identify key requirements for MZ B cell localization and establish a role for integrins in peripheral lymphoid tissue compartmentalization.

Howard Hughes Medical Institute, Department of Microbiology and Immunology, and Division of Pediatric Immunology and Rheumatology, University of California, 513 Parnassus Avenue, San Francisco, CA 94143, USA.
*   To whom correspondence should be addressed. E-mail: cyster{at}itsa.ucsf.edu

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J. Immunol. 173, 2297-2306
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Staphylococcal toxin induced preferential and prolonged in vivo deletion of innate-like B lymphocytes.
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J. Immunol. 173, 866-873
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J. Immunol. 173, 15-19
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J. Immunol. 172, 4159-4166
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J. Immunol. 172, 2076-2083
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The Selection of Marginal Zone B Cells Differs from That of B-1a Cells.
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J. Immunol. 171, 6495-6501
   Abstract »    Full Text »    PDF »
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J. Exp. Med. 198, 333-340
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J. Exp. Med. 197, 1677-1687
   Abstract »    Full Text »    PDF »
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C. G. Lo, T. T. Lu, and J. G. Cyster (2003)
J. Exp. Med. 197, 353-361
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S. G. Tangye, D. T. Avery, E. K. Deenick, and P. D. Hodgkin (2003)
J. Immunol. 170, 686-694
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BOB.1/OBF.1 Deficiency Affects Marginal-Zone B-Cell Compartment.
T. Samardzic, D. Marinkovic, P. J. Nielsen, L. Nitschke, and T. Wirth (2002)
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