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Recent advances in the realization of individual molecular-scale
electronic devices emphasize the need for novel tools andconcepts
capable of assembling such devices into large-scale functionalcircuits. We demonstrated sequence-specific molecular lithographyon
substrate DNA molecules by harnessing homologous recombinationby RecA
protein. In a sequence-specific manner, we patterned thecoating of DNA
with metal, localized labeled molecular objectsand grew metal islands
on specific sites along the DNA substrate,and generated molecularly
accurate stable DNA junctions for patterningthe DNA substrate
connectivity. In our molecular lithography,the information encoded in
the DNA molecules replaces the masksused in conventional
microelectronics, and the RecA protein servesas the resist. The
molecular lithography works with high resolutionover a broad range of
length scales from nanometers to many micrometers.
1 Department of Physics,
2 Solid State Institute, Technion-Israel Institute
of Technology, Haifa 32000, Israel.
*
To whom correspondence should be addressed. E-mail:
erez{at}physics.technion.ac.il
