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Science 21 June 2002:
Vol. 296. no. 5576, pp. 2188 - 2190
DOI: 10.1126/science.1071741
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Review
The Science of ART
Richard M. Schultz,1*
Carmen J. Williams2
The methods of gamete manipulation used in assisted reproductive
technology (ART) are rapidly proliferating and in some instances outpacing the underlying science. In this review, we discuss two major
advances in the ART laboratory--intracytoplasmic sperm injection and
extended embryo culture before embryo transfer. We outline the
rationale for these approaches, discuss results of experiments obtained
from animal model systems and human preimplantation embryos that
provide the scientific basis for these procedures, and point out
potential concerns that have arisen from these studies.
1 Department of Biology, University of
Pennsylvania, Philadelphia, PA 19104-6018, USA.
2 Center for Research on Reproduction and Women's
Health, Department of Obstetrics and Gynecology, University of
Pennsylvania, Philadelphia, PA 19104-6142, USA.
*
To whom correspondence should be addressed. E-mail:
rschultz{at}mail.sas.upenn.edu
Read the Full Text
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