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Science 21 June 2002:
Vol. 296. no. 5576, pp. 2174 - 2176
DOI: 10.1126/science.1071607
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Review

Germline Stem Cell Transplantation and Transgenesis

Ralph L. Brinster

The recently developed testis cell transplantation method provides a powerful approach to studying the biology of the male germline stem cell and its microenvironment, the stem cell niche. The technique also is being used to examine spermatogenic defects, correct male infertility, and generate transgenic animals.

Department of Animal Biology, School of Veterinary Medicine, University of Pennsylvania, 3850 Baltimore Avenue, Philadelphia, PA 19104, USA.

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Reproductive capacity of sperm obtained after germ cell transplantation in a mouse model.
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Restoration of Fertility by Germ Cell Transplantation Requires Effective Recipient Preparation.
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Long-Term Proliferation in Culture and Germline Transmission of Mouse Male Germline Stem Cells.
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Homing Efficiency and Proliferation Kinetics of Male Germ Line Stem Cells Following Transplantation in Mice.
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Spermatogonial stem cells share some, but not all, phenotypic and functional characteristics with other stem cells.
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Male germ-line stem cell potential is predicted by morphology of cells in neonatal rat testes.
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Science. ISSN 0036-8075 (print), 1095-9203 (online)