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Science 14 June 2002:
Vol. 296. no. 5575, pp. 2049 - 2052
DOI: 10.1126/science.1071111
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Reports

Correlated Bursts of Activity in the Neonatal Hippocampus in Vivo

Xavier Leinekugel,123*dagger Rustem Khazipov,14* Robert Cannon,1 Hajime Hirase,2 Yehezkel Ben-Ari,1 György Buzsáki2*

The behavior of immature cortical networks in vivo remains largely unknown. Using multisite extracellular and patch-clamp recordings, we observed recurrent bursts of synchronized neuronal activity lasting 0.5 to 3 seconds that occurred spontaneously in the hippocampus of freely moving and anesthetized rat pups. The influence of slow rhythms (0.33 and 0.1 hertz) and the contribution of both gamma -aminobutyric acid A-mediated and glutamate receptor-mediated synaptic signals in the generation of hippocampal bursts was reminiscent of giant depolarizing potentials observed in vitro. This earliest pattern, which diversifies during the second postnatal week, could provide correlated activity for immature neurons and may underlie activity-dependent maturation of the hippocampal network.

1 INMED, Institut National de la Santé et de la Recherche Médicale (INSERM) U29, Avenue de Luminy, Boite Postale 13, 13273 Marseille Cedex 09, France.
2 Center for Molecular and Behavioral Neuroscience, Rutgers University, 197 University Avenue, Newark, NJ 07102, USA.
3 INSERM EMI 0224 "Cortex et Epilepsie," Faculté de Médecine Pitié-Salpêtrière, Université Paris 6, 105 Boulevard de l'Hôpital, 75013 Paris, France.
4 Children's Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA.
*   These authors contributed equally to this work.

dagger    To whom correspondence should be addressed. E-mail: xlkg{at}noos.fr

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