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Science 14 June 2002:
Vol. 296. no. 5575, pp. 1999 - 2003
DOI: 10.1126/science.1070521
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Research Articles

Temporal Specificity in the Cortical Plasticity of Visual Space Representation

Yu-Xi Fu,* Kaj Djupsund,* Hongfeng Gao,* Benjamin Hayden, Kai Shen, Yang Dandagger

The circuitry and function of mammalian visual cortex are shaped by patterns of visual stimuli, a plasticity likely mediated by synaptic modifications. In the adult cat, asynchronous visual stimuli in two adjacent retinal regions controlled the relative spike timing of two groups of cortical neurons with high precision. This asynchronous pairing induced rapid modifications of intracortical connections and shifts in receptive fields. These changes depended on the temporal order and interval between visual stimuli in a manner consistent with spike timing-dependent synaptic plasticity. Parallel to the cortical modifications found in the cat, such asynchronous visual stimuli also induced shifts in human spatial perception.

Division of Neurobiology, Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA.
*   These authors contributed equally to the work.

dagger    To whom correspondence should be addressed. E-mail: ydan{at}uclink4.berkeley.edu

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