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Science 7 June 2002:
Vol. 296. no. 5574, pp. 1841 - 1844
DOI: 10.1126/science.1072133
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Reports

Microfluidic Control Using Colloidal Devices

Alex Terray, John Oakey,* David W. M. Marr*

By manipulating colloidal microspheres within customized channels, we have created micrometer-scale fluid pumps and particulate valves. We describe two positive-displacement designs, a gear and a peristaltic pump, both of which are about the size of a human red blood cell. Two colloidal valve designs are also demonstrated, one actuated and one passive, for the direction of cells or small particles. The use of colloids as both valves and pumps will allow device integration at a density far beyond what is currently achievable by other approaches and may provide a link between fluid manipulation at the macro- and nanoscale.

Chemical Engineering Department, Colorado School of Mines, Golden, CO 80401, USA.
*   To whom correspondence should be addressed. E-mail: joakey{at}mines.edu (J.O.); dmarr{at}mines.edu (D.W.M.M.)

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Multiphoton fabrication of chemically responsive protein hydrogels for microactuation.
B. Kaehr and J. B. Shear (2008)
PNAS 105, 8850-8854
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Science. ISSN 0036-8075 (print), 1095-9203 (online)