Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.
Science Policy Alerts

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 31 May 2002:
Vol. 296. no. 5573, pp. 1709 - 1711
DOI: 10.1126/science.1069504
Prev | Table of Contents

Reports

Anterior Cingulate: Single Neuronal Signals Related to Degree of Reward Expectancy

Munetaka Shidara,1* Barry J. Richmond2

As monkeys perform schedules containing several trials with a visual cue indicating reward proximity, their error rates decrease as the number of remaining trials decreases, suggesting that their motivation and/or reward expectancy increases as the reward approaches. About one-third of single neurons recorded in the anterior cingulate cortex of monkeys during these reward schedules had responses that progressively changed strength with reward expectancy, an effect that disappeared when the cue was random. Alterations of this progression could be the basis for the changes from normal that are reported in anterior cingulate population activity for obsessive-compulsive disorder and drug abuse, conditions characterized by disturbances in reward expectancy.

1 Neuroscience Research Institute, National Institute of Advanced Industrial Science and Technology, 1-1-1 Umezono, Tsukuba, Ibaraki 305-8568, Japan.
2 Laboratory of Neuropsychology, National Institute of Mental Health, Bethesda, MD 20892, USA.
*   To whom correspondence should be addressed. E-mail: m.shidara{at}aist.go.jp

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Parkinson's disease and dopaminergic therapy--differential effects on movement, reward and cognition.
J. B. Rowe, L. Hughes, B. C. P. Ghosh, D. Eckstein, C. H. Williams-Gray, S. Fallon, R. A. Barker, and A. M. Owen (2008)
Brain 131, 2094-2105
   Abstract »    Full Text »    PDF »
Motivation to do Well Enhances Responses to Errors and Self-Monitoring.
S. L. Bengtsson, H. C. Lau, and R. E. Passingham (2008)
Cereb Cortex
   Abstract »    Full Text »    PDF »
Activity of Primate Orbitofrontal and Dorsolateral Prefrontal Neurons: Effect of Reward Schedule on Task-related Activity..
S. Ichihara-Takeda and S. Funahashi (2008)
J. Cogn. Neurosci. 20, 563-579
   Abstract »    Full Text »    PDF »
Role for NMDA receptors in visceral nociceptive transmission in the anterior cingulate cortex of viscerally hypersensitive rats.
X. Wu, J. Gao, J. Yan, J. Fan, C. Owyang, and Y. Li (2008)
Am J Physiol Gastrointest Liver Physiol 294, G918-G927
   Abstract »    Full Text »    PDF »
Glutamate Release in the Nucleus Accumbens Core Is Necessary for Heroin Seeking.
R. T. LaLumiere and P. W. Kalivas (2008)
J. Neurosci. 28, 3170-3177
   Abstract »    Full Text »    PDF »
Neuronal Activity in the Cingulate Motor Areas During Adaptation to a New Dynamic Environment.
A. G. Richardson, G. Lassi-Tucci, C. Padoa-Schioppa, and E. Bizzi (2008)
J Neurophysiol 99, 1253-1266
   Abstract »    Full Text »    PDF »
Performance Monitoring Local Field Potentials in the Medial Frontal Cortex of Primates: Anterior Cingulate Cortex.
E. E. Emeric, J. W. Brown, M. Leslie, P. Pouget, V. Stuphorn, and J. D. Schall (2008)
J Neurophysiol 99, 759-772
   Abstract »    Full Text »    PDF »
Dynamic Changes in Representations of Preceding and Upcoming Reward in Monkey Orbitofrontal Cortex.
J. M. Simmons and B. J. Richmond (2008)
Cereb Cortex 18, 93-103
   Abstract »    Full Text »    PDF »
Order-Dependent Modulation of Directional Signals in the Supplementary and Presupplementary Motor Areas.
J.-W. Sohn and D. Lee (2007)
J. Neurosci. 27, 13655-13666
   Abstract »    Full Text »    PDF »
Performance Monitoring in the Anterior Cingulate is Not All Error Related: Expectancy Deviation and the Representation of Action-Outcome Associations..
F. T. P. Oliveira, J. J. McDonald, and D. Goodman (2007)
J. Cogn. Neurosci. 19, 1994-2004
   Abstract »    Full Text »    PDF »
History- and Current Instruction-Based Coding of Forthcoming Behavioral Outcomes in the Striatum.
H. Yamada, N. Matsumoto, and M. Kimura (2007)
J Neurophysiol 98, 3557-3567
   Abstract »    Full Text »    PDF »
The Sight of Others' Pain Modulates Motor Processing in Human Cingulate Cortex.
I. Morrison, M. V. Peelen, and P. E. Downing (2007)
Cereb Cortex 17, 2214-2222
   Abstract »    Full Text »    PDF »
Temporal Filtering of Reward Signals in the Dorsal Anterior Cingulate Cortex during a Mixed-Strategy Game.
H. Seo and D. Lee (2007)
J. Neurosci. 27, 8366-8377
   Abstract »    Full Text »    PDF »
Impact of Commitment on Performance Evaluation in the Rostral Cingulate Motor Area.
T. Michelet, B. Bioulac, D. Guehl, L. Escola, and P. Burbaud (2007)
J. Neurosci. 27, 7482-7489
   Abstract »    Full Text »    PDF »
Neural coding of reward magnitude in the orbitofrontal cortex of the rat during a five-odor olfactory discrimination task.
E. van Duuren, F. A. N. Escamez, R. N.J.M.A. Joosten, R. Visser, A. B. Mulder, and C. M.A. Pennartz (2007)
Learn. Mem. 14, 446-456
   Abstract »    Full Text »    PDF »
Temporal Integration by Stochastic Recurrent Network Dynamics With Bimodal Neurons.
H. Okamoto, Y. Isomura, M. Takada, and T. Fukai (2007)
J Neurophysiol 97, 3859-3867
   Abstract »    Full Text »    PDF »
Adaptation of Prefrontal Cortical Firing Patterns and Their Fidelity to Changes in Action-Reward Contingencies.
W. J. Kargo, B. Szatmary, and D. A. Nitz (2007)
J. Neurosci. 27, 3548-3559
   Abstract »    Full Text »    PDF »
Anterior cingulate grey-matter deficits and cannabis use in first-episode schizophrenia.
P. R. Szeszko, D. G. Robinson, S. Sevy, S. Kumra, C. I. Rupp, J. D. Betensky, T. Lencz, M. Ashtari, J. M. Kane, A. K. Malhotra, et al. (2007)
The British Journal of Psychiatry 190, 230-236
   Abstract »    Full Text »    PDF »
The Neural Basis of Addiction: A Pathology of Motivation and Choice.
P. W. Kalivas and N. D. Volkow (2007)
Focus 5, 208-219
   Abstract »    Full Text »    PDF »
Addiction: A Disease of Learning and Memory.
S. E. Hyman (2007)
Focus 5, 220-228
   Abstract »    Full Text »    PDF »
Co-Occurring Mental and Substance Use Disorders: The Neurobiological Effects of Chronic Stress.
K. T. Brady and R. Sinha (2007)
Focus 5, 229-239
   Abstract »    Full Text »    PDF »
Selectivity for the configural cues that identify the gender, ethnicity, and identity of faces in human cortex.
M. Ng, V. M. Ciaramitaro, S. Anstis, G. M. Boynton, and I. Fine (2006)
PNAS 103, 19552-19557
   Abstract »    Full Text »    PDF »
Modulation of Dorsolateral Prefrontal Delay Activity during Self-Organized Behavior..
E. Procyk and P. S Goldman-Rakic (2006)
J. Neurosci. 26, 11313-11323
   Abstract »    Full Text »    PDF »
Neural Representation of Information Measure in the Primate Premotor Cortex.
K. Nakamura (2006)
J Neurophysiol 96, 478-485
   Abstract »    Full Text »    PDF »
Reward Encoding in the Monkey Anterior Cingulate Cortex.
C. Amiez, J.P. Joseph, and E. Procyk (2006)
Cereb Cortex 16, 1040-1055
   Abstract »    Full Text »    PDF »
Role of dopamine in the primate caudate nucleus in reward modulation of saccades..
K. Nakamura and O. Hikosaka (2006)
J. Neurosci. 26, 5360-5369
   Abstract »    Full Text »    PDF »
A biophysically based neural model of matching law behavior: melioration by stochastic synapses..
A. Soltani and X.-J. Wang (2006)
J. Neurosci. 26, 3731-3744
   Abstract »    Full Text »    PDF »
Reward-period Activity in Primate Dorsolateral Prefrontal and Orbitofrontal Neurons Is Affected by Reward Schedules..
S. Ichihara-Takeda and S. Funahashi (2006)
J. Cogn. Neurosci. 18, 212-226
   Abstract »    Full Text »    PDF »
An Effect of Dopamine Depletion on Decision-making: The Temporal Coupling of Deliberation and Execution.
M. Pessiglione, V. Czernecki, B. Pillon, B. Dubois, M. Schupbach, Y. Agid, and L. Tremblay (2005)
J. Cogn. Neurosci. 17, 1886-1896
   Abstract »    Full Text »    PDF »
Neuronal Signals in the Monkey Basolateral Amygdala during Reward Schedules.
Y. Sugase-Miyamoto and B. J. Richmond (2005)
J. Neurosci. 25, 11071-11083
   Abstract »    Full Text »    PDF »
Neuronal Activity in Primate Orbitofrontal Cortex Reflects the Value of Time.
M. R. Roesch and C. R. Olson (2005)
J Neurophysiol 94, 2457-2471
   Abstract »    Full Text »    PDF »
The Neural Basis of Addiction: A Pathology of Motivation and Choice.
P. W. Kalivas and N. D. Volkow (2005)
Am J Psychiatry 162, 1403-1413
   Abstract »    Full Text »    PDF »
Addiction: A Disease of Learning and Memory.
S. E. Hyman (2005)
Am J Psychiatry 162, 1414-1422
   Abstract »    Full Text »    PDF »
Co-Occurring Mental and Substance Use Disorders: The Neurobiological Effects of Chronic Stress.
K. T. Brady and R. Sinha (2005)
Am J Psychiatry 162, 1483-1493
   Abstract »    Full Text »    PDF »
Supplementary Motor Area Encodes Reward Expectancy in Eye-Movement Tasks.
M. Campos, B. Breznen, K. Bernheim, and R. A. Andersen (2005)
J Neurophysiol 94, 1325-1335
   Abstract »    Full Text »    PDF »
Neurons in the Rostral Cingulate Motor Area Monitor Multiple Phases of Visuomotor Behavior With Modest Parametric Selectivity.
E. Hoshi, H. Sawamura, and J. Tanji (2005)
J Neurophysiol 94, 640-656
   Abstract »    Full Text »    PDF »
Alcohol Misuse and Mood Disorders Following Traumatic Brain Injury.
R. E. Jorge, S. E. Starkstein, S. Arndt, D. Moser, B. Crespo-Facorro, and R. G. Robinson (2005)
Arch Gen Psychiatry 62, 742-749
   Abstract »    Full Text »    PDF »
White Matter Abnormalities in Obsessive-compulsive Disorder: A Diffusion Tensor Imaging Study.
P. R. Szeszko, B. A. Ardekani, M. Ashtari, A. K. Malhotra, D. G. Robinson, R. M. Bilder, and K. O. Lim (2005)
Arch Gen Psychiatry 62, 782-790
   Abstract »    Full Text »    PDF »
Complementary Process to Response Bias in the Centromedian Nucleus of the Thalamus.
T. Minamimoto, Y. Hori, and M. Kimura (2005)
Science 308, 1798-1801
   Abstract »    Full Text »    PDF »
Is anterior cingulate cortex necessary for cognitive control?.
L. K. Fellows and M. J. Farah (2005)
Brain 128, 788-796
   Abstract »    Full Text »    PDF »
Frontal-Striatal Dysfunction During Planning in Obsessive-Compulsive Disorder.
O. A. van den Heuvel, D. J. Veltman, H. J. Groenewegen, D. C. Cath, A. J. L. M. van Balkom, J. van Hartskamp, F. Barkhof, and R. van Dyck (2005)
Arch Gen Psychiatry 62, 301-309
   Abstract »    Full Text »    PDF »
The Role of the Medial Frontal Cortex in Cognitive Control.
K. R. Ridderinkhof, M. Ullsperger, E. A. Crone, and S. Nieuwenhuis (2004)
Science 306, 443-447
   Abstract »    Full Text »    PDF »
The Cognitive Neuroscience of Human Decision Making: A Review and Conceptual Framework.
L. K. Fellows (2004)
Behav Cogn Neurosci Rev 3, 159-172
   Abstract »    PDF »
Inactivation of the Anterior Cingulate Cortex Impairs Extinction of Rabbit Jaw Movement Conditioning and Prevents Extinction-Related Inhibition of Hippocampal Activity.
A. L. Griffin and S. D. Berry (2004)
Learn. Mem. 11, 604-610
   Abstract »    Full Text »    PDF »
Participation of the Primate Presupplementary Motor Area in Sequencing Multiple Saccades.
M. Isoda and J. Tanji (2004)
J Neurophysiol 92, 653-659
   Abstract »    Full Text »    PDF »
Brain Structural Abnormalities in Psychotropic Drug-Naive Pediatric Patients With Obsessive-Compulsive Disorder.
P. R. Szeszko, S. MacMillan, M. McMeniman, S. Chen, K. Baribault, K. O. Lim, J. Ivey, M. Rose, S. P. Banerjee, R. Bhandari, et al. (2004)
Am J Psychiatry 161, 1049-1056
   Abstract »    Full Text »    PDF »
Behavioral Context and Coherent Oscillations in the Supplementary Motor Area.
D. Lee (2004)
J. Neurosci. 24, 4453-4459
   Abstract »    Full Text »    PDF »
Neuronal Activity Related to Reward Value and Motivation in Primate Frontal Cortex.
M. R. Roesch and C. R. Olson (2004)
Science 304, 307-310
   Abstract »    Full Text »    PDF »
Neural Correlates of Beauty.
H. Kawabata and S. Zeki (2004)
J Neurophysiol 91, 1699-1705
   Abstract »    Full Text »    PDF »
The Neural Correlates of Cue-Induced Craving in Cocaine-Dependent Women.
C. D. Kilts, R. E. Gross, T. D. Ely, and K. P.G. Drexler (2004)
Am J Psychiatry 161, 233-241
   Abstract »    Full Text »    PDF »
Neural Correlates of Rewarded and Unrewarded Eye Movements in the Primate Caudate Nucleus.
K. Watanabe, J. Lauwereyns, and O. Hikosaka (2003)
J. Neurosci. 23, 10052-10057
   Abstract »    Full Text »    PDF »
Performance Monitoring by the Anterior Cingulate Cortex During Saccade Countermanding.
S. Ito, V. Stuphorn, J. W. Brown, and J. D. Schall (2003)
Science 302, 120-122
   Abstract »    Full Text »    PDF »
Neural Coding of "Attention for Action" and "Response Selection" in Primate Anterior Cingulate Cortex.
Y. Isomura, Y. Ito, T. Akazawa, A. Nambu, and M. Takada (2003)
J. Neurosci. 23, 8002-8012
   Abstract »    Full Text »    PDF »
Activation of the Anterior Cingulate Gyrus by 'Green Odor': A Positron Emission Tomography Study in the Monkey.
T. Sasabe, M. Kobayashi, Y. Kondo, H. Onoe, S. Matsubara, S. Yamamoto, H. Tsukada, K. Onoe, H. Watabe, H. Iida, et al. (2003)
Chem Senses 28, 565-572
   Abstract »    Full Text »    PDF »
Impact of Expected Reward on Neuronal Activity in Prefrontal Cortex, Frontal and Supplementary Eye Fields and Premotor Cortex.
M. R. Roesch and C. R. Olson (2003)
J Neurophysiol 90, 1766-1789
   Abstract »    Full Text »    PDF »
Functional Specialization within Medial Frontal Cortex of the Anterior Cingulate for Evaluating Effort-Related Decisions.
M. E. Walton, D. M. Bannerman, K. Alterescu, and M. F. S. Rushworth (2003)
J. Neurosci. 23, 6475-6479
   Abstract »    Full Text »    PDF »
Neuronal Correlates of Goal-Based Motor Selection in the Prefrontal Cortex.
K. Matsumoto, W. Suzuki, and K. Tanaka (2003)
Science 301, 229-232
   Abstract »    Full Text »    PDF »
Effects of Expectations for Different Reward Magnitudes on Neuronal Activity in Primate Striatum.
H. C. Cromwell and W. Schultz (2003)
J Neurophysiol 89, 2823-2838
   Abstract »    Full Text »    PDF »
The Anterior Cingulate and Reward-Guided Selection of Actions.
K. A. Hadland, M.F.S. Rushworth, D. Gaffan, and R. E. Passingham (2003)
J Neurophysiol 89, 1161-1164
   Abstract »    Full Text »    PDF »
Activity in the Supplementary Motor Area Related to Learning and Performance During a Sequential Visuomotor Task.
D. Lee and S. Quessy (2003)
J Neurophysiol 89, 1039-1056
   Abstract »    Full Text »    PDF »


ADVERTISEMENT
Click Me!

ADVERTISEMENT
Click Me!

To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)