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Anterior Cingulate: Single Neuronal Signals Related to Degree of Reward Expectancy
Munetaka Shidara,1*Barry J. Richmond2
As monkeys perform schedules containing several trials with a
visual cue indicating reward proximity, their error rates decreaseas
the number of remaining trials decreases, suggesting that theirmotivation and/or reward expectancy increases as the reward approaches.About one-third of single neurons recorded in the anterior cingulatecortex of monkeys during these reward schedules had responsesthat
progressively changed strength with reward expectancy, aneffect that
disappeared when the cue was random. Alterations ofthis progression
could be the basis for the changes from normalthat are reported in
anterior cingulate population activity forobsessive-compulsive
disorder and drug abuse, conditions characterizedby disturbances in
reward expectancy.
1 Neuroscience Research Institute, National
Institute of Advanced Industrial Science and Technology, 1-1-1 Umezono,
Tsukuba, Ibaraki 305-8568, Japan.
2 Laboratory of
Neuropsychology, National Institute of Mental Health, Bethesda, MD
20892, USA.
*
To whom correspondence should be addressed. E-mail:
m.shidara{at}aist.go.jp
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