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Science 31 May 2002:
Vol. 296. no. 5573, pp. 1653 - 1655
DOI: 10.1126/science.1071545
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A Road Map for Those Who Don't Know JAK-STAT

David S. Aaronson,1 Curt M. Horvath2*

The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transmits information received from extracellular polypeptide signals, through transmembrane receptors, directly to target gene promoters in the nucleus, providing a mechanism for transcriptional regulation without second messengers. Evolutionarily conserved in eukaryotic organisms from slime molds to humans, JAK-STAT signaling appears to be an early adaptation to facilitate intercellular communication that has co-evolved with myriad cellular signaling events. This co-evolution has given rise to highly adapted, ligand-specific signaling pathways that control gene expression. In addition, the JAK-STAT signaling pathways are regulated by a vast array of intrinsic and environmental stimuli, which can add plasticity to the response of a cell or tissue.

1 Department of Pharmacology and Biological Chemistry,
2 Immunobiology Center, Mount Sinai School of Medicine, New York, NY 10029 USA.
*   To whom correspondence should be addressed. E-mail: curt.horvath{at}mssm.edu

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