Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 31 May 2002:
Vol. 296. no. 5573, pp. 1653 - 1655
DOI: 10.1126/science.1071545
Prev | Table of Contents | Next

Viewpoint

A Road Map for Those Who Don't Know JAK-STAT

David S. Aaronson,1 Curt M. Horvath2*

The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transmits information received from extracellular polypeptide signals, through transmembrane receptors, directly to target gene promoters in the nucleus, providing a mechanism for transcriptional regulation without second messengers. Evolutionarily conserved in eukaryotic organisms from slime molds to humans, JAK-STAT signaling appears to be an early adaptation to facilitate intercellular communication that has co-evolved with myriad cellular signaling events. This co-evolution has given rise to highly adapted, ligand-specific signaling pathways that control gene expression. In addition, the JAK-STAT signaling pathways are regulated by a vast array of intrinsic and environmental stimuli, which can add plasticity to the response of a cell or tissue.

1 Department of Pharmacology and Biological Chemistry,
2 Immunobiology Center, Mount Sinai School of Medicine, New York, NY 10029 USA.
*   To whom correspondence should be addressed. E-mail: curt.horvath{at}mssm.edu

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Mammalian Casein Kinase 1{alpha} and Its Leishmanial Ortholog Regulate Stability of IFNAR1 and Type I Interferon Signaling.
J. Liu, L. P. Carvalho, S. Bhattacharya, C. J. Carbone, K. G. S. Kumar, N. A. Leu, P. M. Yau, R. G. K. Donald, M. J. Weiss, D. P. Baker, et al. (2009)
Mol. Cell. Biol. 29, 6401-6412
   Abstract »    Full Text »    PDF »
The Macrophage Cholesterol Exporter ABCA1 Functions as an Anti-inflammatory Receptor.
C. Tang, Y. Liu, P. S. Kessler, A. M. Vaughan, and J. F. Oram (2009)
J. Biol. Chem. 284, 32336-32343
   Abstract »    Full Text »    PDF »
Src-dependent STAT-3-mediated Expression of Monocyte Chemoattractant Protein-1 Is Required for 15(S)-Hydroxyeicosatetraenoic Acid-induced Vascular Smooth Muscle Cell Migration.
H. S. K. Potula, D. Wang, D. Van Quyen, N. K. Singh, V. Kundumani-Sridharan, M. Karpurapu, E. A. Park, W. C. Glasgow, and G. N. Rao (2009)
J. Biol. Chem. 284, 31142-31155
   Abstract »    Full Text »    PDF »
Dietary Saturated Fat Modulates the Association between STAT3 Polymorphisms and Abdominal Obesity in Adults.
C. M. Phillips, L. Goumidi, S. Bertrais, M. R. Field, G. M. Peloso, J. Shen, R. McManus, S. Hercberg, D. Lairon, R. Planells, et al. (2009)
J. Nutr. 139, 2011-2017
   Abstract »    Full Text »    PDF »
Hyperactivated B cells in human inflammatory bowel disease.
A. M. Noronha, Y. Liang, J. T. Hetzel, H. Hasturk, A. Kantarci, A. Stucchi, Y. Zhang, B. S. Nikolajczyk, F. A. Farraye, and L. M. Ganley-Leal (2009)
J. Leukoc. Biol. 86, 1007-1016
   Abstract »    Full Text »    PDF »
Reduction of Stat3 Activity Attenuates HIV-Induced Kidney Injury.
X. Feng, T.-C. Lu, P. Y. Chuang, W. Fang, K. Ratnam, H. Xiong, X. Ouyang, Y. Shen, D. E. Levy, D. Hyink, et al. (2009)
J. Am. Soc. Nephrol. 20, 2138-2146
   Abstract »    Full Text »    PDF »
Regulation of JAK2 by miR-135a: prognostic impact in classic Hodgkin lymphoma.
A. Navarro, T. Diaz, A. Martinez, A. Gaya, A. Pons, B. Gel, C. Codony, G. Ferrer, C. Martinez, E. Montserrat, et al. (2009)
Blood 114, 2945-2951
   Abstract »    Full Text »    PDF »
17-Hydroxy-jolkinolide B Inhibits Signal Transducers and Activators of Transcription 3 Signaling by Covalently Cross-Linking Janus Kinases and Induces Apoptosis of Human Cancer Cells.
Y. Wang, X. Ma, S. Yan, S. Shen, H. Zhu, Y. Gu, H. Wang, G. Qin, and Q. Yu (2009)
Cancer Res. 69, 7302-7310
   Abstract »    Full Text »    PDF »
Oncogenic EGFR Signaling Networks in Glioma.
P. H. Huang, A. M. Xu, and F. M. White (2009)
Science Signaling 2, re6
   Abstract »    Full Text »    PDF »
Synergistic Induction of Endothelin-1 by Tumor Necrosis Factor {alpha} and Interferon {gamma} Is due to Enhanced NF-{kappa}B Binding and Histone Acetylation at Specific {kappa}B Sites.
S. J. Wort, M. Ito, P.-C. Chou, S. K. Mc Master, R. Badiger, E. Jazrawi, P. de Souza, T. W. Evans, J. A. Mitchell, L. Pinhu, et al. (2009)
J. Biol. Chem. 284, 24297-24305
   Abstract »    Full Text »    PDF »
A Point Mutation, E95D, in the Mumps Virus V Protein Disengages STAT3 Targeting from STAT1 Targeting.
M. Puri, K. Lemon, W. P. Duprex, B. K. Rima, and C. M. Horvath (2009)
J. Virol. 83, 6347-6356
   Abstract »    Full Text »    PDF »
Barley Stem Rust Resistance Genes: Structure and Function.
A. Kleinhofs, R. Brueggeman, J. Nirmala, L. Zhang, A. Mirlohi, A. Druka, N. Rostoks, and B. J. Steffenson (2009)
The Plant Genome 2, 109-120
   Abstract »    Full Text »    PDF »
Gaussian process regression bootstrapping: exploring the effects of uncertainty in time course data.
P. D. W. Kirk and M. P. H. Stumpf (2009)
Bioinformatics 25, 1300-1306
   Abstract »    Full Text »    PDF »
Nucleotide Sequences and Modifications That Determine RIG-I/RNA Binding and Signaling Activities.
D. Uzri and L. Gehrke (2009)
J. Virol. 83, 4174-4184
   Abstract »    Full Text »    PDF »
A rapid simple approach to quantify chromosome conformation capture.
M. Abou El Hassan and R. Bremner (2009)
Nucleic Acids Res. 37, e35
   Abstract »    Full Text »    PDF »
Protein Tyrosine Phosphatases Regulate Asthma Development in a Murine Asthma Model.
P. Pouliot, P. Camateros, D. Radzioch, B. N. Lambrecht, and M. Olivier (2009)
J. Immunol. 182, 1334-1340
   Abstract »    Full Text »    PDF »
Dual Regulatory Roles of Phosphatidylinositol 3-Kinase in IFN Signaling.
S. Kaur, A. Sassano, A. M. Joseph, B. Majchrzak-Kita, E. A. Eklund, A. Verma, S. M. Brachmann, E. N. Fish, and L. C. Platanias (2008)
J. Immunol. 181, 7316-7323
   Abstract »    Full Text »    PDF »
SOCS-3 Inhibits E2F/DP-1 Transcriptional Activity and Cell Cycle Progression via Interaction with DP-1.
Y. Masuhiro, K. Kayama, A. Fukushima, K. Baba, M. Soutsu, Y. Kamiya, M. Gotoh, N. Yamaguchi, and S. Hanazawa (2008)
J. Biol. Chem. 283, 31575-31583
   Abstract »    Full Text »    PDF »
Interferon-{gamma} inhibits cellular proliferation and ACTH production in corticotroph tumor cells through a novel janus kinases-signal transducer and activator of transcription 1/nuclear factor-kappa B inhibitory signaling pathway.
M. Labeur, D. Refojo, B. Wolfel, J. Stalla, V. Vargas, M. Theodoropoulou, M. Buchfelder, M. Paez-Pereda, E. Arzt, and G. K Stalla (2008)
J. Endocrinol. 199, 177-189
   Abstract »    Full Text »    PDF »
BDNF Selectively Regulates GABAA Receptor Transcription by Activation of the JAK/STAT Pathway.
I. V. Lund, Y. Hu, Y. H. Raol, R. S. Benham, R. Faris, S. J. Russek, and A. R. Brooks-Kayal (2008)
Science Signaling 1, ra9
   Abstract »    Full Text »    PDF »
Discordant on/off switching of gene expression in myocytes during cardiac hypertrophy in vivo.
K. Pandya, J. Cowhig, J. Brackhan, H. S. Kim, J. Hagaman, M. Rojas, C. W. Carter Jr, L. Mao, H. A. Rockman, N. Maeda, et al. (2008)
PNAS 105, 13063-13068
   Abstract »    Full Text »    PDF »
STAT3 is a Critical Regulator of Astrogliosis and Scar Formation after Spinal Cord Injury.
J. E. Herrmann, T. Imura, B. Song, J. Qi, Y. Ao, T. K. Nguyen, R. A. Korsak, K. Takeda, S. Akira, and M. V. Sofroniew (2008)
J. Neurosci. 28, 7231-7243
   Abstract »    Full Text »    PDF »
Interleukin-6 as a Photoreceptor Neuroprotectant in an Experimental Model of Retinal Detachment.
D. Y. Chong, C. S. Boehlke, Q.-D. Zheng, L. Zhang, Y. Han, and D. N. Zacks (2008)
Invest. Ophthalmol. Vis. Sci. 49, 3193-3200
   Abstract »    Full Text »    PDF »
Henipavirus V Protein Association with Polo-Like Kinase Reveals Functional Overlap with STAT1 Binding and Interferon Evasion.
L. E. Ludlow, M. K. Lo, J. J. Rodriguez, P. A. Rota, and C. M. Horvath (2008)
J. Virol. 82, 6259-6271
   Abstract »    Full Text »    PDF »
Signal transducer and activator of transcription 5A/B in prostate and breast cancers.
S.-H. Tan and M. T Nevalainen (2008)
Endocr. Relat. Cancer 15, 367-390
   Abstract »    Full Text »    PDF »
Suppression of Interferon (IFN)-inducible Genes and IFN-mediated Functional Responses in BCR-ABL-expressing Cells.
E. Katsoulidis, A. Sassano, B. Majchrzak-Kita, N. Carayol, P. Yoon, A. Jordan, B. J. Druker, E. N. Fish, and L. C. Platanias (2008)
J. Biol. Chem. 283, 10793-10803
   Abstract »    Full Text »    PDF »
Triterpenoid CDDO-Methyl Ester Inhibits the Janus-Activated Kinase-1 (JAK1)->Signal Transducer and Activator of Transcription-3 (STAT3) Pathway by Direct Inhibition of JAK1 and STAT3.
R. Ahmad, D. Raina, C. Meyer, and D. Kufe (2008)
Cancer Res. 68, 2920-2926
   Abstract »    Full Text »    PDF »
Disease-Modifying Mutations in Familial Hypertrophic Cardiomyopathy: Complexity From Simplicity.
D. Hilfiker-Kleiner and R. Knoll (2008)
Circulation 117, 1775-1777
   Full Text »    PDF »
Phosphorylation of Human Jak3 at Tyrosines 904 and 939 Positively Regulates Its Activity.
H. Cheng, J. A. Ross, J. A. Frost, and R. A. Kirken (2008)
Mol. Cell. Biol. 28, 2271-2282
   Abstract »    Full Text »    PDF »
PDGF-C and -D Induced Proliferation/Migration of Human RPE Is Abolished by Inflammatory Cytokines.
R. Li, A. Maminishkis, F. E. Wang, and S. S. Miller (2007)
Invest. Ophthalmol. Vis. Sci. 48, 5722-5732
   Abstract »    Full Text »    PDF »
JAK kinases promote invasiveness in VHL-mediated renal cell carcinoma by a suppressor of cytokine signaling-regulated, HIF-independent mechanism.
K. L. Wu, H. Miao, and S. Khan (2007)
Am J Physiol Renal Physiol 293, F1836-F1846
   Abstract »    Full Text »    PDF »
Signal transducer and activator of transcription 3-regulated sarcoendoplasmic reticulum Ca2+-ATPase 2 expression by prolactin and glucocorticoids is involved in the adaptation of insulin secretory response during the peripartum period.
G. F Anhe, T. C A Nogueira, J. E Nicoletti-Carvalho, C. Lellis-Santos, H. C Barbosa, J. Cipolla-Neto, J. R Bosqueiro, A. C Boschero, and S. Bordin (2007)
J. Endocrinol. 195, 17-27
   Abstract »    Full Text »    PDF »
Hyperproliferative apoptosis-resistant endothelial cells in idiopathic pulmonary arterial hypertension.
F. A. Masri, W. Xu, S. A. A. Comhair, K. Asosingh, M. Koo, A. Vasanji, J. Drazba, B. Anand-Apte, and S. C. Erzurum (2007)
Am J Physiol Lung Cell Mol Physiol 293, L548-L554
   Abstract »    Full Text »    PDF »
Laminar flow attenuates interferon-induced inflammatory responses in endothelial cells.
Y.-C. Tsai, H.-J. Hsieh, F. Liao, C.-W. Ni, Y.-J. Chao, C.-Y. Hsieh, and D. L. Wang (2007)
Cardiovasc Res 74, 497-505
   Abstract »    Full Text »    PDF »
TC-PTP-deficient bone marrow stromal cells fail to support normal B lymphopoiesis due to abnormal secretion of interferon-{gamma}.
A. Bourdeau, N. Dube, K. M. Heinonen, J.-F. Theberge, K. M. Doody, and M. L. Tremblay (2007)
Blood 109, 4220-4228
   Abstract »    Full Text »    PDF »
Modulation of Gamma Interferon Receptor 1 by Mycobacterium tuberculosis: a Potential Immune Response Evasive Mechanism.
A. Singhal, A. Jaiswal, V. K. Arora, and H. K. Prasad (2007)
Infect. Immun. 75, 2500-2510
   Abstract »    Full Text »    PDF »
Cellular FLICE-inhibitory protein regulates chemotherapy-induced apoptosis in breast cancer cells.
K. M.A. Rogers, M. Thomas, L. Galligan, T. R. Wilson, W. L. Allen, H. Sakai, P. G. Johnston, and D. B. Longley (2007)
Mol. Cancer Ther. 6, 1544-1551
   Abstract »    Full Text »    PDF »
Retinoic Acid-Inducible Gene I Mediates Early Antiviral Response and Toll-Like Receptor 3 Expression in Respiratory Syncytial Virus-Infected Airway Epithelial Cells.
P. Liu, M. Jamaluddin, K. Li, R. P. Garofalo, A. Casola, and A. R. Brasier (2007)
J. Virol. 81, 1401-1411
   Abstract »    Full Text »    PDF »
IFN{gamma} synergizes with IL-1{beta} to up-regulate MMP-9 secretion in a cellular model of central nervous system tuberculosis.
J. E. Harris, M. Fernandez-Vilaseca, P. T. G. Elkington, D. E. Horncastle, M. B. Graeber, and J. S. Friedland (2007)
FASEB J 21, 356-365
   Abstract »    Full Text »    PDF »
Inactivation of Signal Transducer and Activator of Transcription 3 in Proopiomelanocortin (Pomc) Neurons Causes Decreased Pomc Expression, Mild Obesity, and Defects in Compensatory Refeeding.
A. W. Xu, L. Ste-Marie, C. B. Kaelin, and G. S. Barsh (2007)
Endocrinology 148, 72-80
   Abstract »    Full Text »    PDF »
Differential role of Jak-STAT signaling in retinal degenerations.
M. Samardzija, A. Wenzel, S. Aufenberg, M. Thiersch, C. Reme, and C. Grimm (2006)
FASEB J 20, 2411-2413
   Abstract »    Full Text »    PDF »
Signal Transducer and Activator of Transcription (Stat) Binding Sites But Not Stat3 Are Required for Fasting-Induced Transcription of Agouti-Related Protein Messenger Ribonucleic Acid.
C. B. Kaelin, L. Gong, A. W. Xu, F. Yao, K. Hockman, G. J. Morton, M. W. Schwartz, G. S. Barsh, and R. G. MacKenzie (2006)
Mol. Endocrinol. 20, 2591-2602
   Abstract »    Full Text »    PDF »
STAT1-Independent Cell Type-Specific Regulation of Antiviral APOBEC3G by IFN-{alpha}.
P. T. N. Sarkis, S. Ying, R. Xu, and X.-F. Yu (2006)
J. Immunol. 177, 4530-4540
   Abstract »    Full Text »    PDF »
Cloning of porcine signal transducer and activator of transcription 3 cDNA and its expression in reproductive tissues..
L. Wen, J. Craig, P. W Dyce, and J. Li (2006)
Reproduction 132, 511-518
   Abstract »    Full Text »    PDF »
Cardiac fibroblasts: friend or foe?.
T. A. Baudino, W. Carver, W. Giles, and T. K. Borg (2006)
Am J Physiol Heart Circ Physiol 291, H1015-H1026
   Abstract »    Full Text »    PDF »
Haplotype of Signal Transducer and Activator of Transcription 3 Gene Predicts Cardiovascular Disease in Dialysis Patients.
L. Zhang, W.H. L. Kao, Y. Berthier-Schaad, Y. Liu, L. Plantinga, B. G. Jaar, N. Fink, N. Powe, M. J. Klag, M. W. Smith, et al. (2006)
J. Am. Soc. Nephrol. 17, 2285-2292
   Abstract »    Full Text »    PDF »
Arginine-Vasopressin Activates the JAK-STAT Pathway in Vascular Smooth Muscle Cells.
O. Levy and Y. Granot (2006)
J. Biol. Chem. 281, 15597-15604
   Abstract »    Full Text »    PDF »
Cytokine-induced metabolic effects in human adipocytes are independent of endogenous nitric oxide.
P. Linscheid, D. Seboek, H. Zulewski, A. Scherberich, N. Blau, U. Keller, and B. Muller (2006)
Am J Physiol Endocrinol Metab 290, E1068-E1077
   Abstract »    Full Text »    PDF »
Tid1 Isoforms Are Mitochondrial DnaJ-like Chaperones with Unique Carboxyl Termini That Determine Cytosolic Fate.
B. Lu, N. Garrido, J. N. Spelbrink, and C. K. Suzuki (2006)
J. Biol. Chem. 281, 13150-13158
   Abstract »    Full Text »    PDF »
Inhibition of Interferon Signaling by Rabies Virus Phosphoprotein P: Activation-Dependent Binding of STAT1 and STAT2.
K. Brzozka, S. Finke, and K.-K. Conzelmann (2006)
J. Virol. 80, 2675-2683
   Abstract »    Full Text »    PDF »
A human cytomegalovirus antagonist of type I IFN-dependent signal transducer and activator of transcription signaling.
C. Paulus, S. Krauss, and M. Nevels (2006)
PNAS 103, 3840-3845
   Abstract »    Full Text »    PDF »
Pathways of matrix metalloproteinase induction in heart failure: Bioactive molecules and transcriptional regulation.
A. M. Deschamps and F. G. Spinale (2006)
Cardiovasc Res 69, 666-676
   Abstract »    Full Text »    PDF »
Epigenetic modification of SOCS-1 differentially regulates STAT3 activation in response to interleukin-6 receptor and epidermal growth factor receptor signaling through JAK and/or MEK in head and neck squamous cell carcinomas.
T. L. Lee, J. Yeh, C. Van Waes, and Z. Chen (2006)
Mol. Cancer Ther. 5, 8-19
   Abstract »    Full Text »    PDF »
Flavopiridol disrupts STAT3/DNA interactions, attenuates STAT3-directed transcription, and combines with the Jak kinase inhibitor AG490 to achieve cytotoxic synergy.
Y. K. Lee, C. R. Isham, S. H. Kaufman, and K. C. Bible (2006)
Mol. Cancer Ther. 5, 138-148
   Abstract »    Full Text »    PDF »
A Distal Regulatory Region Is Required for Constitutive and IFN-{beta}-Induced Expression of Murine TLR9 Gene.
Z. Guo, S. Garg, K. M. Hill, L. Jayashankar, M. R. Mooney, M. Hoelscher, J. M. Katz, J. M. Boss, and S. Sambhara (2005)
J. Immunol. 175, 7407-7418
   Abstract »    Full Text »    PDF »
Rabies Virus P Protein Interacts with STAT1 and Inhibits Interferon Signal Transduction Pathways.
A. Vidy, M. Chelbi-Alix, and D. Blondel (2005)
J. Virol. 79, 14411-14420
   Abstract »    Full Text »    PDF »
Altered gene expression in myeloproliferative disorders correlates with activation of signaling by the V617F mutation of Jak2.
R. Kralovics, S.-S. Teo, A. S. Buser, M. Brutsche, R. Tiedt, A. Tichelli, F. Passamonti, D. Pietra, M. Cazzola, and R. C. Skoda (2005)
Blood 106, 3374-3376
   Abstract »    Full Text »    PDF »
Treatment of Autoimmune Neuroinflammation with a Synthetic Tryptophan Metabolite.
M. Platten, P. P. Ho, S. Youssef, P. Fontoura, H. Garren, E. M. Hur, R. Gupta, L. Y. Lee, B. A. Kidd, W. H. Robinson, et al. (2005)
Science 310, 850-855
   Abstract »    Full Text »    PDF »
Cyclooxygenase-2-Dependent Activation of Signal Transducer and Activator of Transcription 3 by Interleukin-6 in Non-Small Cell Lung Cancer.
H. Dalwadi, K. Krysan, N. Heuze-Vourc'h, M. Dohadwala, D. Elashoff, S. Sharma, N. Cacalano, A. Lichtenstein, and S. Dubinett (2005)
Clin. Cancer Res. 11, 7674-7682
   Abstract »    Full Text »    PDF »
Apical role for BRG1 in cytokine-induced promoter assembly.
Z. Ni, E. Karaskov, T. Yu, S. M. Callaghan, S. Der, D. S. Park, Z. Xu, S. G. Pattenden, and R. Bremner (2005)
PNAS 102, 14611-14616
   Abstract »    Full Text »    PDF »
Attenuated Rabies Virus Activates, while Pathogenic Rabies Virus Evades, the Host Innate Immune Responses in the Central Nervous System.
Z. W. Wang, L. Sarmento, Y. Wang, X.-q. Li, V. Dhingra, T. Tseggai, B. Jiang, and Z. F. Fu (2005)
J. Virol. 79, 12554-12565
   Abstract »    Full Text »    PDF »
Association Between Peroxisome Proliferator-Activated Receptor {gamma} Haplotypes and the Metabolic Syndrome in French Men and Women.
A. Meirhaeghe, D. Cottel, P. Amouyel, and J. Dallongeville (2005)
Diabetes 54, 3043-3048
   Abstract »    Full Text »    PDF »
Composition and Assembly of STAT-Targeting Ubiquitin Ligase Complexes: Paramyxovirus V Protein Carboxyl Terminus Is an Oligomerization Domain.
C. M. Ulane, A. Kentsis, C. D. Cruz, J.-P. Parisien, K. L. Schneider, and C. M. Horvath (2005)
J. Virol. 79, 10180-10189
   Abstract »    Full Text »    PDF »
Histone Deacetylases as Transcriptional Activators? Role Reversal in Inducible Gene Regulation.
I. Nusinzon and C. M. Horvath (2005)
Sci. STKE 2005, re11
   Abstract »    Full Text »    PDF »
Domain 2 of the Urokinase Receptor Contains an Integrin-interacting Epitope with Intrinsic Signaling Activity: GENERATION OF A NEW INTEGRIN INHIBITOR.
B. Degryse, M. Resnati, R.-P. Czekay, D. J. Loskutoff, and F. Blasi (2005)
J. Biol. Chem. 280, 24792-24803
   Abstract »    Full Text »    PDF »
Signal Transducer and Activator of Transcription 3{alpha} and Specificity Protein 1 Interact to Upregulate Intercellular Adhesion Molecule-1 in Ischemic-Reperfused Myocardium and Vascular Endothelium.
X. P. Yang, K. Irani, S. Mattagajasingh, A. DiPaula, F. Khanday, M. Ozaki, K. Fox-Talbot, W. M. Baldwin III, and L. C. Becker (2005)
Arterioscler Thromb Vasc Biol 25, 1395-1400
   Abstract »    Full Text »    PDF »
Progestins Induce Transcriptional Activation of Signal Transducer and Activator of Transcription 3 (Stat3) via a Jak- and Src-Dependent Mechanism in Breast Cancer Cells.
C. Proietti, M. Salatino, C. Rosemblit, R. Carnevale, A. Pecci, A. R. Kornblihtt, A. A. Molinolo, I. Frahm, E. H. Charreau, R. Schillaci, et al. (2005)
Mol. Cell. Biol. 25, 4826-4840
   Abstract »    Full Text »    PDF »
Up-Regulation of the JAK/STAT1 Signal Pathway during Chlamydia trachomatis Infection.
S. P. Lad, E. Y. Fukuda, J. Li, L. M. de la Maza, and E. Li (2005)
J. Immunol. 174, 7186-7193
   Abstract »    Full Text »    PDF »
A cytomegaloviral protein reveals a dual role for STAT2 in IFN-{gamma} signaling and antiviral responses.
A. Zimmermann, M. Trilling, M. Wagner, M. Wilborn, I. Bubic, S. Jonjic, U. Koszinowski, and H. Hengel (2005)
J. Exp. Med. 201, 1543-1553
   Abstract »    Full Text »    PDF »
STAT3- and DNA methyltransferase 1-mediated epigenetic silencing of SHP-1 tyrosine phosphatase tumor suppressor gene in malignant T lymphocytes.
Q. Zhang, H. Y. Wang, M. Marzec, P. N. Raghunath, T. Nagasawa, and M. A. Wasik (2005)
PNAS 102, 6948-6953
   Abstract »    Full Text »    PDF »
Transcriptional Activation of Alpha/Beta Interferon Genes: Interference by Nonsegmented Negative-Strand RNA Viruses.
K.-K. Conzelmann (2005)
J. Virol. 79, 5241-5248
   Full Text »    PDF »
Synthesis of {alpha}-Chemokines IP-10, I-TAC, and MIG Are Differentially Regulated in Human Corneal Keratocytes.
K. A. McInnis, A. Britain, R. N. Lausch, and J. E. Oakes (2005)
Invest. Ophthalmol. Vis. Sci. 46, 1668-1674
   Abstract »    Full Text »    PDF »
Expression and activation of STAT3 in chronic proliferative immune complex glomerulonephritis and the effect of fosinopril.
W. Zhang, X. Chen, S. Shi, R. Wei, J. Wang, N. Yamanaka, and Q. Hong (2005)
Nephrol. Dial. Transplant. 20, 892-901
   Abstract »    Full Text »    PDF »
A Gain-of-Function Mutation of JAK2 in Myeloproliferative Disorders.
R. Kralovics, F. Passamonti, A. S. Buser, S.-S. Teo, R. Tiedt, J. R. Passweg, A. Tichelli, M. Cazzola, and R. C. Skoda (2005)
N. Engl. J. Med. 352, 1779-1790
   Abstract »    Full Text »    PDF »
Farnesyl Transferase Inhibitor (R115777)-Induced Inhibition of STAT3(Tyr705) Phosphorylation in Human Pancreatic Cancer Cell Lines Require Extracellular Signal-Regulated Kinases.
K. Venkatasubbarao, A. Choudary, and J. W. Freeman (2005)
Cancer Res. 65, 2861-2871
   Abstract »    Full Text »    PDF »
Activation of Mitogen-activated Protein Kinase Kinase (MKK) 3 and MKK6 by Type I Interferons.
Y. Li, S. Batra, A. Sassano, B. Majchrzak, D. E. Levy, M. Gaestel, E. N. Fish, R. J. Davis, and L. C. Platanias (2005)
J. Biol. Chem. 280, 10001-10010
   Abstract »    Full Text »    PDF »
PKC{delta} plays opposite roles in growth mediated by wild-type Kit and an oncogenic Kit mutant.
T. Jelacic and D. Linnekin (2005)
Blood 105, 1923-1929
   Abstract »    Full Text »    PDF »
Identification of the Cytoplasmic Domains of CXCR4 Involved in Jak2 and STAT3 Phosphorylation.
B. Ahr, M. Denizot, V. Robert-Hebmann, A. Brelot, and M. Biard-Piechaczyk (2005)
J. Biol. Chem. 280, 6692-6700
   Abstract »    Full Text »    PDF »
Conditioning Injury-Induced Spinal Axon Regeneration Requires Signal Transducer and Activator of Transcription 3 Activation.
J. Qiu, W. B. J. Cafferty, S. B. McMahon, and S. W. N. Thompson (2005)
J. Neurosci. 25, 1645-1653
   Abstract »    Full Text »    PDF »
Isolation of Unique STAT5 Targets by Chromatin Immunoprecipitation-based Gene Identification.
E. A. Nelson, S. R. Walker, J. V. Alvarez, and D. A. Frank (2004)
J. Biol. Chem. 279, 54724-54730
   Abstract »    Full Text »    PDF »
Prolactin Signals Through RUSH/SMARCA3 in the Absence of a Physical Association with Stat5a.
A. Hewetson, S. L. Moore, and B. S. Chilton (2004)
Biol Reprod 71, 1907-1912
   Abstract »    Full Text »    PDF »
Interferon {gamma} Enhances the Effectiveness of Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Receptor Agonists in a Xenograft Model of Ewing's Sarcoma.
M. S. Merchant, X. Yang, F. Melchionda, M. Romero, R. Klein, C. J. Thiele, M. Tsokos, H. U. Kontny, and C. L. Mackall (2004)
Cancer Res. 64, 8349-8356
   Abstract »    Full Text »    PDF »
Protein Kinase C{delta} Regulates Apoptosis via Activation of STAT1.
T. A. DeVries, R. L. Kalkofen, A. A. Matassa, and M. E. Reyland (2004)
J. Biol. Chem. 279, 45603-45612
   Abstract »    Full Text »    PDF »
Novel Aspects of Growth Hormone (GH) Autoregulation: GH-Induced GH Gene Expression in Grass Carp Pituitary Cells through Autocrine/Paracrine Mechanisms.
H. Zhou, W. K. W. Ko, W. K. K. Ho, S. S. Stojilkovic, and A. O. L. Wong (2004)
Endocrinology 145, 4615-4628
   Abstract »    Full Text »    PDF »
Engagement of Protein Kinase C-{theta} in Interferon Signaling in T-cells.
K. K. Srivastava, S. Batra, A. Sassano, Y. Li, B. Majchrzak, H. Kiyokawa, A. Altman, E. N. Fish, and L. C. Platanias (2004)
J. Biol. Chem. 279, 29911-29920
   Abstract »    Full Text »    PDF »
Characterization of the Amino Acid Residues of Sendai Virus C Protein That Are Critically Involved in Its Interferon Antagonism and RNA Synthesis Down-Regulation.
A. Kato, C. Cortese-Grogan, S. A. Moyer, F. Sugahara, T. Sakaguchi, T. Kubota, N. Otsuki, M. Kohase, M. Tashiro, and Y. Nagai (2004)
J. Virol. 78, 7443-7454
   Abstract »    Full Text »    PDF »
Induction of Suppressor of Cytokine Signaling-3 by Herpes Simplex Virus Type 1 Contributes to Inhibition of the Interferon Signaling Pathway.
S.-i. Yokota, N. Yokosawa, T. Okabayashi, T. Suzutani, S. Miura, K. Jimbow, and N. Fujii (2004)
J. Virol. 78, 6282-6286
   Abstract »    Full Text »    PDF »
Angiotensin II Increases Pax-2 Expression in Fetal Kidney Cells Via the AT2 Receptor.
S.-L. Zhang, B. Moini, and J. R. Ingelfinger (2004)
J. Am. Soc. Nephrol. 15, 1452-1465
   Abstract »    Full Text »    PDF »
The Low Density Lipoprotein Receptor-related Protein Is a Motogenic Receptor for Plasminogen Activator Inhibitor-1.
B. Degryse, J. G. Neels, R.-P. Czekay, K. Aertgeerts, Y.-i. Kamikubo, and D. J. Loskutoff (2004)
J. Biol. Chem. 279, 22595-22604
   Abstract »    Full Text »    PDF »
Identification of the Nuclear Export Signal and STAT-Binding Domains of the Nipah Virus V Protein Reveals Mechanisms Underlying Interferon Evasion.
J. J. Rodriguez, C. D. Cruz, and C. M. Horvath (2004)
J. Virol. 78, 5358-5367
   Abstract »    Full Text »    PDF »
Tyrosine 813 Is a Site of JAK2 Autophosphorylation Critical for Activation of JAK2 by SH2-B{beta}.
J. H. Kurzer, L. S. Argetsinger, Y.-J. Zhou, J.-L. K. Kouadio, J. J. O'Shea, and C. Carter-Su (2004)
Mol. Cell. Biol. 24, 4557-4570
   Abstract »    Full Text »    PDF »
Identification of Transcription Factor Binding Sites Upstream of Human Genes Regulated by the Phosphatidylinositol 3-Kinase and MEK/ERK Signaling Pathways.
J. W. Tullai, M. E. Schaffer, S. Mullenbrock, S. Kasif, and G. M. Cooper (2004)
J. Biol. Chem. 279, 20167-20177
   Abstract »    Full Text »    PDF »
Identification of the Jak/Stat Proteins as Novel Downstream Targets of EphA4 Signaling in Muscle: IMPLICATIONS IN THE REGULATION OF ACETYLCHOLINESTERASE EXPRESSION.
K.-O. Lai, Y. Chen, H.-M. Po, K.-C. Lok, K. Gong, and N. Y. Ip (2004)
J. Biol. Chem. 279, 13383-13392
   Abstract »    Full Text »    PDF »
Androgen Receptor Signaling: Mechanism of Interleukin-6 Inhibition.
L. Jia, C. S-Y. Choong, C. Ricciardelli, J. Kim, W. D. Tilley, and G. A Coetzee (2004)
Cancer Res. 64, 2619-2626
   Abstract »    Full Text »    PDF »
The JAK/STAT signaling pathway.
J. S. Rawlings, K. M. Rosler, and D. A. Harrison (2004)
J. Cell Sci. 117, 1281-1283
   Full Text »    PDF »
Role of p38{alpha} Map Kinase in Type I Interferon Signaling.
Y. Li, A. Sassano, B. Majchrzak, D. K. Deb, D. E. Levy, M. Gaestel, A. R. Nebreda, E. N. Fish, and L. C. Platanias (2004)
J. Biol. Chem. 279, 970-979
   Abstract »    Full Text »    PDF »
Survival Strategy of Obligately Intracellular Ehrlichia chaffeensis: Novel Modulation of Immune Response and Host Cell Cycles.
J.-z. Zhang, M. Sinha, B. A. Luxon, and X.-j. Yu (2004)
Infect. Immun. 72, 498-507
   Abstract »    Full Text »    PDF »
Loss of dystrophin causes aberrant mechanotransduction in skeletal muscle fibers.
A. KUMAR, N. KHANDELWAL, R. MALYA, M. B. REID, and A. M. BORIEK (2004)
FASEB J 18, 102-113
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)