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Science 31 May 2002:
Vol. 296. no. 5573, pp. 1652 - 1653
DOI: 10.1126/science.296.5573.1652
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Integrin Connections Map: To Infinity and Beyond

Karen H. Martin, Jill K. Slack, Scott A. Boerner, Clifford C. Martin, J. Thomas Parsons*

Integrins are transmembrane proteins that serve as primary sensors of the extracellular matrix (ECM) environment. In response to interactions with the ECM, integrins initiate signaling pathways that regulate cell migration, growth, and survival. Advances in imaging have contributed to the understanding of the dynamic nature of these cell-ECM interactions and the complexes that form at these sites and have provided insights into their regulation and signal organizing functions.

Department of Microbiology, University of Virginia Health System, Box 800734, Charlottesville, VA 22908-0734, USA.
*   To whom correspondence should be addressed: E-mail: jtp{at}virginia.edu

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