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Science 31 May 2002:
Vol. 296. no. 5573, pp. 1641 - 1642
DOI: 10.1126/science.1071546
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B Cell Antigen Receptor Signaling: Roles in Cell Development and Disease

Stephen B. Gauld, Joseph M. Dal Porto, John C. Cambier*

Signals propagated through the B cell antigen receptor (BCR) are vital for the development and survival of B lymphocytes in both the bone marrow and the periphery. These signals not only guide maturation and activation but also affect the removal of potentially self-reactive B lymphocytes. Interestingly, these signals are known to be either ligand-independent ("tonic" signals) or induced by ligand (antigen) binding to the BCR. We focus on the problems that occur in B cell development due to defects in signals emanating from the BCR. In addition, we present the B Cell Antigen Receptor Pathway, an STKE Connections Map that illustrates the events involved in B cell signaling.

Integrated Department of Immunology, University of Colorado Health Sciences Center, and National Jewish Medical Research Center, 1400 Jackson Street, Denver, CO 80206, USA.
*   To whom correspondence should be addressed. E-mail: cambierj{at}njc.org

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