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Science 31 May 2002:
Vol. 296. no. 5573, pp. 1636 - 1639
DOI: 10.1126/science.1071550
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G Protein Pathways

Susana R. Neves, Prahlad T. Ram, Ravi Iyengar*

The heterotrimeric guanine nucleotide-binding proteins (G proteins) are signal transducers that communicate signals from many hormones, neurotransmitters, chemokines, and autocrine and paracrine factors. The extracellular signals are received by members of a large superfamily of receptors with seven membrane-spanning regions that activate the G proteins, which route the signals to several distinct intracellular signaling pathways. These pathways interact with one another to form a network that regulates metabolic enzymes, ion channels, transporters, and other components of the cellular machinery controlling a broad range of cellular processes, including transcription, motility, contractility, and secretion. These cellular processes in turn regulate systemic functions such as embryonic development, gonadal development, learning and memory, and organismal homeostasis.

Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, New York, NY 10029, USA.
*   To whom correspondence should be addressed. E-mail: ravi.iyengar{at}mssm.edu

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The Orphan Nuclear Receptors NURR1 and NGFIB Regulate Adrenal Aldosterone Production.
M. H. Bassett, T. Suzuki, H. Sasano, P. C. White, and W. E. Rainey (2004)
Mol. Endocrinol. 18, 279-290
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Expression and Function of Gonadotropin-releasing Hormone (GnRH) Receptor in Human Olfactory GnRH-secreting Neurons: AN AUTOCRINE GnRH LOOP UNDERLIES NEURONAL MIGRATION.
R. G. Romanelli, T. Barni, M. Maggi, M. Luconi, P. Failli, A. Pezzatini, E. Pelo, F. Torricelli, C. Crescioli, P. Ferruzzi, et al. (2004)
J. Biol. Chem. 279, 117-126
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The Ca2+-sensing receptor couples to G{alpha}12/13 to activate phospholipase D in Madin-Darby canine kidney cells.
C. Huang, K. M. Hujer, Z. Wu, and R. T. Miller (2004)
Am J Physiol Cell Physiol 286, C22-C30
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G-protein-coupled receptors at a glance.
W. K. Kroeze, D. J. Sheffler, and B. L. Roth (2003)
J. Cell Sci. 116, 4867-4869
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Insights into G Protein Structure, Function, and Regulation.
T. M. Cabrera-Vera, J. Vanhauwe, T. O. Thomas, M. Medkova, A. Preininger, M. R. Mazzoni, and H. E. Hamm (2003)
Endocr. Rev. 24, 765-781
   Abstract »    Full Text »    PDF »
Regulators of G Protein Signaling and Transient Activation of Signaling: EXPERIMENTAL AND COMPUTATIONAL ANALYSIS REVEALS NEGATIVE AND POSITIVE FEEDBACK CONTROLS ON G PROTEIN ACTIVITY.
N. Hao, N. Yildirim, Y. Wang, T. C. Elston, and H. G. Dohlman (2003)
J. Biol. Chem. 278, 46506-46515
   Abstract »    Full Text »    PDF »
TCR-mediated hyper-responsiveness of autoimmune G{alpha}i2-/- mice is an intrinsic naive CD4+ T cell disorder selective for the G{alpha}i2 subunit.
T. T. Huang, Y. Zong, H. Dalwadi, C. Chung, M. C. Miceli, K. Spicher, L. Birnbaumer, J. Braun, and R. Aranda (2003)
Int. Immunol. 15, 1359-1367
   Abstract »    Full Text »    PDF »
Erythrocyte G Protein-Coupled Receptor Signaling in Malarial Infection.
T. Harrison, B. U. Samuel, T. Akompong, H. Hamm, N. Mohandas, J. W. Lomasney, and K. Haldar (2003)
Science 301, 1734-1736
   Abstract »    Full Text »    PDF »
A Kelch {beta} Propeller Featuring as a G{beta} Structural Mimic: Reinventing the Wheel?.
J. Gettemans, K. Meerschaert, J. Vandekerckhove, and V. De Corte (2003)
Sci. STKE 2003, pe27
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