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Direct Recognition of Cytomegalovirus by Activating and Inhibitory NK Cell Receptors
Hisashi Arase,1Edward S. Mocarski,2Ann E. Campbell,3Ann B. Hill,4Lewis L. Lanier1*
Natural killer (NK) cells express inhibitory receptors
for major histocompatibility complex (MHC) class I antigens, preventingattack against healthy cells. Mouse cytomegalovirus (MCMV)
encodesan MHC-like protein (m157) that binds to an inhibitory NK cellreceptor in certain MCMV-susceptible mice. In MCMV-resistant mice,this
viral protein engages a related activating receptor (Ly49H)and confers
host protection. These activating and inhibitory receptorsare highly
homologous, suggesting the possibility that one evolvedfrom the other
in response to selective pressure imposed by thepathogen.
1 Department of Microbiology and Immunology and
the Cancer Research Institute, University of California San Francisco,
San Francisco, CA 94143, USA.
2 Department of
Microbiology and Immunology, Stanford University, Stanford, CA 94305, USA.
3 Department of Microbiology and Molecular Cell
Biology, Eastern Virginia Medical School, Norfolk, VA 23507, USA.
4 Department of Molecular Microbiology and
Immunology, Oregon Health Sciences University, Portland, OR 97201, USA.
*
To whom correspondence should be addressed. E-mail:
lanier{at}itsa.ucsf.edu
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S. Chiesa, M. Mingueneau, N. Fuseri, B. Malissen, D. H. Raulet, M. Malissen, E. Vivier, and E. Tomasello (2006)
Blood
107, 2364-2372
|Abstract »|Full Text »|PDF »
Phospholipase C-{gamma}2 is essential for NK cell cytotoxicity and innate immunity to malignant and virally infected cells.
A. Caraux, N. Kim, S. E. Bell, S. Zompi, T. Ranson, S. Lesjean-Pottier, M. E. Garcia-Ojeda, M. Turner, and F. Colucci (2006)
Blood
107, 994-1002
|Abstract »|Full Text »|PDF »
The Inhibitory Receptor NKG2A Determines Lysis of Vaccinia Virus-Infected Autologous Targets by NK Cells.
C. R. Brooks, T. Elliott, P. Parham, and S. I. Khakoo (2006)
J. Immunol.
176, 1141-1147
|Abstract »|Full Text »|PDF »
Expression of m157, a Murine Cytomegalovirus-Encoded Putative Major Histocompatibility Class I (MHC-I)-Like Protein, Is Independent of Viral Regulation of Host MHC-I.
S. K. Tripathy, H. R. C. Smith, E. A. Holroyd, J. T. Pingel, and W. M. Yokoyama (2006)
J. Virol.
80, 545-550
|Abstract »|Full Text »|PDF »
Viral strategies for evading antiviral cellular immune responses of the host.
A. Iannello, O. Debbeche, E. Martin, L. H. Attalah, S. Samarani, and A. Ahmad (2006)
J. Leukoc. Biol.
79, 16-35
|Abstract »|Full Text »|PDF »
Suppression of tumor formation in lymph nodes by L-selectin-mediated natural killer cell recruitment.
S. Chen, H. Kawashima, J. B. Lowe, L. L. Lanier, and M. Fukuda (2005)
J. Exp. Med.
202, 1679-1689
|Abstract »|Full Text »|PDF »
Signal Regulatory Proteins in the Immune System.
E. M. van Beek, F. Cochrane, A. N. Barclay, and T. K. van den Berg (2005)
J. Immunol.
175, 7781-7787
|Abstract »|Full Text »|PDF »
Cutting Edge: Lectin-Like Transcript-1 Is a Ligand for the Inhibitory Human NKR-P1A Receptor.
D. B. Rosen, J. Bettadapura, M. Alsharifi, P. A. Mathew, H. S. Warren, and L. L. Lanier (2005)
J. Immunol.
175, 7796-7799
|Abstract »|Full Text »|PDF »
