Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.
A Complex with Chromatin Modifiers That Occupies E2F- and Myc-Responsive Genes in G0 Cells
Hidesato Ogawa,*Kei-ichiro Ishiguro,*Stefan Gaubatz,David M. Livingston,Yoshihiro Nakatani
E2F-6 contributes to gene silencing in a manner
independent of retinoblastoma protein family members. To better
elucidatethe molecular mechanism of repression by E2F-6, we have
purifiedthe factor from cultured cells. E2F-6 is found in a multimericprotein complex that contains Mga and Max, and thus the complexcan
bind not only to the E2F-binding site but also to Myc- andBrachyury-binding sites. Moreover, the complex contains chromatinmodifiers such as a novel histone methyltransferase that modifieslysine 9 of histone H3, HP1, and Polycomb group (PcG) proteins.The
E2F-6 complex preferentially occupies target promoters inG0 cells rather than in G1 cells. These data
suggest that thesechromatin modifiers contribute to silencing of E2F-
and Myc-responsivegenes in quiescent cells.
Dana-Farber Cancer Institute and Harvard Medical School, Boston,
MA 02115, USA.
*
These authors contributed equally to this work.
Present address: Institute for Molecular Biology and
Tumor Research, Philipps-University Marburg, D-35032 Marburg, Germany.
To whom correspondence should be addressed. E-mail:
yoshihiro_nakatani{at}dfci.harvard.edu
Dual role for the methyltransferase G9a in the maintenance of {beta}-globin gene transcription in adult erythroid cells.
C.-P. Chaturvedi, A. M. Hosey, C. Palii, C. Perez-Iratxeta, Y. Nakatani, J. A. Ranish, F. J. Dilworth, and M. Brand (2009)
PNAS
106, 18303-18308
|Abstract »|Full Text »|PDF »
Further clinical and molecular delineation of the 9q subtelomeric deletion syndrome supports a major contribution of EHMT1 haploinsufficiency to the core phenotype.
T Kleefstra, W A van Zelst-Stams, W M Nillesen, V Cormier-Daire, G Houge, N Foulds, M van Dooren, M H Willemsen, R Pfundt, A Turner, et al. (2009)
J. Med. Genet.
46, 598-606
|Abstract »|Full Text »|PDF »
LSD1-mediated epigenetic modification is required for TAL1 function and hematopoiesis.
X. Hu, X. Li, K. Valverde, X. Fu, C. Noguchi, Y. Qiu, and S. Huang (2009)
PNAS
106, 10141-10146
|Abstract »|Full Text »|PDF »
Dynamic Histone H1 Isotype 4 Methylation and Demethylation by Histone Lysine Methyltransferase G9a/KMT1C and the Jumonji Domain-containing JMJD2/KDM4 Proteins.
P. Trojer, J. Zhang, M. Yonezawa, A. Schmidt, H. Zheng, T. Jenuwein, and D. Reinberg (2009)
J. Biol. Chem.
284, 8395-8405
|Abstract »|Full Text »|PDF »
A Chicken Ovalbumin Upstream Promoter Transcription Factor I (COUP-TFI) Complex Represses Expression of the Gene Encoding Tumor Necrosis Factor {alpha}-induced Protein 8 (TNFAIP8).
L.-j. Zhang, X. Liu, P. R. Gafken, C. Kioussi, and M. Leid (2009)
J. Biol. Chem.
284, 6156-6168
|Abstract »|Full Text »|PDF »
A Jumonji (Jarid2) Protein Complex Represses cyclin D1 Expression by Methylation of Histone H3-K9.
H. Shirato, S. Ogawa, K. Nakajima, M. Inagawa, M. Kojima, M. Tachibana, Y. Shinkai, and T. Takeuchi (2009)
J. Biol. Chem.
284, 733-739
|Abstract »|Full Text »|PDF »
Identification of Aurora-A as a Direct Target of E2F3 during G2/M Cell Cycle Progression.
L. He, H. Yang, Y. Ma, W. J. Pledger, W. D. Cress, and J. Q. Cheng (2008)
J. Biol. Chem.
283, 31012-31020
|Abstract »|Full Text »|PDF »
Generation of a highly inducible Gal4->Fluc universal reporter mouse for in vivo bioluminescence imaging.
A. Pichler, J. L. Prior, G. D. Luker, and D. Piwnica-Worms (2008)
PNAS
105, 15932-15937
|Abstract »|Full Text »|PDF »
Human Papillomavirus Type 16 E7 Oncoprotein Associates with E2F6.
M. E. McLaughlin-Drubin, K.-W. Huh, and K. Munger (2008)
J. Virol.
82, 8695-8705
|Abstract »|Full Text »|PDF »
Characterization of Drosophila G9a in vivo and identification of genetic interactants..
Y. Kato, M. Kato, M. Tachibana, Y. Shinkai, and M. Yamaguchi (2008)
Genes Cells
13, 703-722
|Abstract »|Full Text »|PDF »
Transcription factor Ap2{delta} associates with Ash2l and ALR, a trithorax family histone methyltransferase, to activate Hoxc8 transcription.
C. C. Tan, K. V. Sindhu, S. Li, H. Nishio, J. Z. Stoller, K. Oishi, S. Puttreddy, T. J. Lee, J. A. Epstein, M. J. Walsh, et al. (2008)
PNAS
105, 7472-7477
|Abstract »|Full Text »|PDF »
Erasing the methyl mark: histone demethylases at the center of cellular differentiation and disease.
P. A.C. Cloos, J. Christensen, K. Agger, and K. Helin (2008)
Genes & Dev.
22, 1115-1140
|Abstract »|Full Text »|PDF »
Corepressor CtBP and Nuclear Speckle Protein Pnn/DRS Differentially Modulate Transcription and Splicing of the E-Cadherin Gene.
R. Alpatov, Y. Shi, G. C. Munguba, B. Moghimi, J.-H. Joo, J. Bungert, and S. P. Sugrue (2008)
Mol. Cell. Biol.
28, 1584-1595
|Abstract »|Full Text »|PDF »
Inactivation of the Polycomb Group Protein Ring1B Unveils an Antiproliferative Role in Hematopoietic Cell Expansion and Cooperation with Tumorigenesis Associated with Ink4a Deletion.
C. Cales, M. Roman-Trufero, L. Pavon, I. Serrano, T. Melgar, M. Endoh, C. Perez, H. Koseki, and M. Vidal (2008)
Mol. Cell. Biol.
28, 1018-1028
|Abstract »|Full Text »|PDF »
G9a Histone Methyltransferase Contributes to Imprinting in the Mouse Placenta.
A. Wagschal, H. G. Sutherland, K. Woodfine, A. Henckel, K. Chebli, R. Schulz, R. J. Oakey, W. A. Bickmore, and R. Feil (2008)
Mol. Cell. Biol.
28, 1104-1113
|Abstract »|Full Text »|PDF »
Mechanisms of primary and secondary estrogen target gene regulation in breast cancer cells.
V. Bourdeau, J. Deschenes, D. Laperriere, M. Aid, J. H. White, and S. Mader (2008)
Nucleic Acids Res.
36, 76-93
|Abstract »|Full Text »|PDF »
ICBP90, a Novel Methyl K9 H3 Binding Protein Linking Protein Ubiquitination with Heterochromatin Formation.
P. Karagianni, L. Amazit, J. Qin, and J. Wong (2008)
Mol. Cell. Biol.
28, 705-717
|Abstract »|Full Text »|PDF »
Polycomb complexes regulate cellular senescence by repression of ARF in cooperation with E2F3..
J. Miki, Y.-i. Fujimura, H. Koseki, and T. Kamijo (2007)
Genes Cells
12, 1371-1382
|Abstract »|Full Text »|PDF »
USF1 Recruits Histone Modification Complexes and Is Critical for Maintenance of a Chromatin Barrier.
S. Huang, X. Li, T. M. Yusufzai, Y. Qiu, and G. Felsenfeld (2007)
Mol. Cell. Biol.
27, 7991-8002
|Abstract »|Full Text »|PDF »
A comprehensive ChIP chip analysis of E2F1, E2F4, and E2F6 in normal and tumor cells reveals interchangeable roles of E2F family members.
X. Xu, M. Bieda, V. X. Jin, A. Rabinovich, M. J. Oberley, R. Green, and P. J. Farnham (2007)
Genome Res.
17, 1550-1561
|Abstract »|Full Text »|PDF »
Identification of ZNF200 as a novel binding partner of histone H3 methyltransferase G9a.
M. Nishida, M. Kato, Y. Kato, N. Sasai, J. Ueda, M. Tachibana, Y. Shinkai, and M. Yamaguchi (2007)
Genes Cells
12, 877-888
|Abstract »|Full Text »|PDF »
A genome-wide RNA interference screen identifies putative chromatin regulators essential for E2F repression.
Proteomics Analysis of Ring1B/Rnf2 Interactors Identifies a Novel Complex with the Fbxl10/Jhdm1B Histone Demethylase and the Bcl6 Interacting Corepressor.
C. Sanchez, I. Sanchez, J. A. A. Demmers, P. Rodriguez, J. Strouboulis, and M. Vidal (2007)
Mol. Cell. Proteomics
6, 820-834
|Abstract »|Full Text »|PDF »
LIN-61, One of Two Caenorhabditis elegans Malignant-Brain-Tumor-Repeat-Containing Proteins, Acts With the DRM and NuRD-Like Protein Complexes in Vulval Development but Not in Certain Other Biological Processes.
Targeting of AMSH to Endosomes Is Required for Epidermal Growth Factor Receptor Degradation.
Y. M. Ma, E. Boucrot, J. Villen, E. B. Affar, S. P. Gygi, H. G. Gottlinger, and T. Kirchhausen (2007)
J. Biol. Chem.
282, 9805-9812
|Abstract »|Full Text »|PDF »
Coordinated Recruitment of Histone Methyltransferase G9a and Other Chromatin-Modifying Enzymes in SHP-Mediated Regulation of Hepatic Bile Acid Metabolism.
S. Fang, J. Miao, L. Xiang, B. Ponugoti, E. Treuter, and J. K. Kemper (2007)
Mol. Cell. Biol.
27, 1407-1424
|Abstract »|Full Text »|PDF »
HP1 Proteins Are Essential for a Dynamic Nuclear Response That Rescues the Function of Perturbed Heterochromatin in Primary Human Cells.
R. Zhang, S.-t. Liu, W. Chen, M. Bonner, J. Pehrson, T. J. Yen, and P. D. Adams (2007)
Mol. Cell. Biol.
27, 949-962
|Abstract »|Full Text »|PDF »
Mammalian Polycomb Scmh1 mediates exclusion of Polycomb complexes from the XY body in the pachytene spermatocytes.
Y. Takada, K.-i. Isono, J. Shinga, J. M. A. Turner, H. Kitamura, O. Ohara, G. Watanabe, P. B. Singh, T. Kamijo, T. Jenuwein, et al. (2007)
Development
134, 579-590
|Abstract »|Full Text »|PDF »
E2f1, E2f2, and E2f3 Control E2F Target Expression and Cellular Proliferation via a p53-Dependent Negative Feedback Loop.
C. Timmers, N. Sharma, R. Opavsky, B. Maiti, L. Wu, J. Wu, D. Orringer, P. Trikha, H. I. Saavedra, and G. Leone (2007)
Mol. Cell. Biol.
27, 65-78
|Abstract »|Full Text »|PDF »
Prothymosin {alpha} Interacts with Free Core Histones in the Nucleus of Dividing Cells.
G. Covelo, C. S. Sarandeses, C. Diaz-Jullien, and M. Freire (2006)
J. Biochem.
140, 627-637
|Abstract »|Full Text »|PDF »
Isolation and characterization of the TIGA genes, whose transcripts are induced by growth arrest.
N. Yabuta, H. Onda, M. Watanabe, N. Yoshioka, I. Nagamori, T. Funatsu, S. Toji, K. Tamai, and H. Nojima (2006)
Nucleic Acids Res.
34, 4878-4892
|Abstract »|Full Text »|PDF »
Yaf2 Inhibits Caspase 8-mediated Apoptosis and Regulates Cell Survival during Zebrafish Embryogenesis.
S. E. Stanton, L. J. McReynolds, T. Evans, and N. Schreiber-Agus (2006)
J. Biol. Chem.
281, 28782-28793
|Abstract »|Full Text »|PDF »
Polycomb Group and SCF Ubiquitin Ligases Are Found in a Novel BCOR Complex That Is Recruited to BCL6 Targets..
M. D. Gearhart, C. M. Corcoran, J. A. Wamstad, and V. J. Bardwell (2006)
Mol. Cell. Biol.
26, 6880-6889
|Abstract »|Full Text »|PDF »
Bok, Bcl-2-related Ovarian Killer, Is Cell Cycle-regulated and Sensitizes to Stress-induced Apoptosis.
J. M. Rodriguez, M. A. Glozak, Y. Ma, and W. D. Cress (2006)
J. Biol. Chem.
281, 22729-22735
|Abstract »|Full Text »|PDF »
E2f4 regulates fetal erythropoiesis through the promotion of cellular proliferation.
K. M. Kinross, A. J. Clark, R. M. Iazzolino, and P. O. Humbert (2006)
Blood
108, 886-895
|Abstract »|Full Text »|PDF »
Zinc Finger Protein Wiz Links G9a/GLP Histone Methyltransferases to the Co-repressor Molecule CtBP.
J. Ueda, M. Tachibana, T. Ikura, and Y. Shinkai (2006)
J. Biol. Chem.
281, 20120-20128
|Abstract »|Full Text »|PDF »
The Histone Methyltransferase SETDB1 and the DNA Methyltransferase DNMT3A Interact Directly and Localize to Promoters Silenced in Cancer Cells.
H. Li, T. Rauch, Z.-X. Chen, P. E. Szabo, A. D. Riggs, and G. P. Pfeifer (2006)
J. Biol. Chem.
281, 19489-19500
|Abstract »|Full Text »|PDF »
A human DNA polymerase eta complex containing Rad18, Rad6 and Rev1; proteomic analysis and targeting of the complex to the chromatin-bound fraction of cells undergoing replication fork arrest..
M. S. Yuasa, C. Masutani, A. Hirano, M. A. Cohn, M. Yamaizumi, Y. Nakatani, and F. Hanaoka (2006)
Genes Cells
11, 731-744
|Abstract »|Full Text »|PDF »
C. D. Knights, J. Catania, S. D. Giovanni, S. Muratoglu, R. Perez, A. Swartzbeck, A. A. Quong, X. Zhang, T. Beerman, R. G. Pestell, et al. (2006)
J. Cell Biol.
173, 533-544
|Abstract »|Full Text »|PDF »
Direct Control of Cell Cycle Gene Expression by Proto-Oncogene Product ACTR, and Its Autoregulation Underlies Its Transforming Activity.
M. C. Louie, A. S. Revenko, J. X. Zou, J. Yao, and H.-W. Chen (2006)
Mol. Cell. Biol.
26, 3810-3823
|Abstract »|Full Text »|PDF »
Silenced tumor suppressor genes reactivated by DNA demethylation do not return to a fully euchromatic chromatin state..
K. M. McGarvey, J. A. Fahrner, E. Greene, J. Martens, T. Jenuwein, and S. B. Baylin (2006)
Cancer Res.
66, 3541-3549
|Abstract »|Full Text »|PDF »
Ubiquitin C-terminal hydrolase L1 regulates the morphology of neural progenitor cells and modulates their differentiation.
M. Sakurai, K. Ayukawa, R. Setsuie, K. Nishikawa, Y. Hara, H. Ohashi, M. Nishimoto, T. Abe, Y. Kudo, M. Sekiguchi, et al. (2006)
J. Cell Sci.
119, 162-171
|Abstract »|Full Text »|PDF »
Silencing of the Meiotic Genes SMC1{beta} and STAG3 in Somatic Cells by E2F6.
J. Storre, A. Schafer, N. Reichert, J. L. Barbero, S. Hauser, M. Eilers, and S. Gaubatz (2005)
J. Biol. Chem.
280, 41380-41386
|Abstract »|Full Text »|PDF »
Gfi1 Coordinates Epigenetic Repression of p21Cip/WAF1 by Recruitment of Histone Lysine Methyltransferase G9a and Histone Deacetylase 1.
Z. Duan, A. Zarebski, D. Montoya-Durango, H. L. Grimes, and M. Horwitz (2005)
Mol. Cell. Biol.
25, 10338-10351
|Abstract »|Full Text »|PDF »
Pocket Protein Complexes Are Recruited to Distinct Targets in Quiescent and Proliferating Cells.
E. Balciunaite, A. Spektor, N. H. Lents, H. Cam, H. te Riele, A. Scime, M. A. Rudnicki, R. Young, and B. D. Dynlacht (2005)
Mol. Cell. Biol.
25, 8166-8178
|Abstract »|Full Text »|PDF »
Rybp/DEDAF Is Required for Early Postimplantation and for Central Nervous System Development.
M. K. Pirity, J. Locker, and N. Schreiber-Agus (2005)
Mol. Cell. Biol.
25, 7193-7202
|Abstract »|Full Text »|PDF »
Functional analysis of the N- and C-terminus of mammalian G9a histone H3 methyltransferase.
P.-O. Esteve, D. Patnaik, H. G. Chin, J. Benner, M. A. Teitell, and S. Pradhan (2005)
Nucleic Acids Res.
33, 3211-3223
|Abstract »|Full Text »|PDF »
Interaction of tSNARE Syntaxin 18 with the Papillomavirus Minor Capsid Protein Mediates Infection.
I. Bossis, R. B. S. Roden, R. Gambhira, R. Yang, M. Tagaya, P. M. Howley, and P. I. Meneses (2005)
J. Virol.
79, 6723-6731
|Abstract »|Full Text »|PDF »
In Vivo HP1 Targeting Causes Large-Scale Chromatin Condensation and Enhanced Histone Lysine Methylation.
P. J. Verschure, I. van der Kraan, W. de Leeuw, J. van der Vlag, A. E. Carpenter, A. S. Belmont, and R. van Driel (2005)
Mol. Cell. Biol.
25, 4552-4564
|Abstract »|Full Text »|PDF »
Differential Subnuclear Localization and Replication Timing of Histone H3 Lysine 9 Methylation States.
R. Wu, A. V. Terry, P. B. Singh, and D. M. Gilbert (2005)
Mol. Biol. Cell
16, 2872-2881
|Abstract »|Full Text »|PDF »
Cloning and Characterization of Mouse E2F8, a Novel Mammalian E2F Family Member Capable of Blocking Cellular Proliferation.
B. Maiti, J. Li, A. de Bruin, F. Gordon, C. Timmers, R. Opavsky, K. Patil, J. Tuttle, W. Cleghorn, and G. Leone (2005)
J. Biol. Chem.
280, 18211-18220
|Abstract »|Full Text »|PDF »
Synthetic Lethality of Retinoblastoma Mutant Cells in the Drosophila Eye by Mutation of a Novel Peptidyl Prolyl Isomerase Gene.
K. A. Edgar, M. Belvin, A. L. Parks, K. Whittaker, M. B. Mahoney, M. Nicoll, C. C. Park, C. G. Winter, F. Chen, K. Lickteig, et al. (2005)
Genetics
170, 161-171
|Abstract »|Full Text »|PDF »
Disruption of the gene Euchromatin Histone Methyl Transferase1 (Eu-HMTase1) is associated with the 9q34 subtelomeric deletion syndrome.
T Kleefstra, M Smidt, M J G Banning, A R Oudakker, H Van Esch, A P M de Brouwer, W Nillesen, E A Sistermans, B C J Hamel, D de Bruijn, et al. (2005)
J. Med. Genet.
42, 299-306
|Abstract »|Full Text »|PDF »
Histone methyltransferases G9a and GLP form heteromeric complexes and are both crucial for methylation of euchromatin at H3-K9.
M. Tachibana, J. Ueda, M. Fukuda, N. Takeda, T. Ohta, H. Iwanari, T. Sakihama, T. Kodama, T. Hamakubo, and Y. Shinkai (2005)
Genes & Dev.
19, 815-826
|Abstract »|Full Text »|PDF »
In Vitro and in Vivo Analyses of a Phe/Tyr Switch Controlling Product Specificity of Histone Lysine Methyltransferases.
R. E. Collins, M. Tachibana, H. Tamaru, K. M. Smith, D. Jia, X. Zhang, E. U. Selker, Y. Shinkai, and X. Cheng (2005)
J. Biol. Chem.
280, 5563-5570
|Abstract »|Full Text »|PDF »
A Novel Repressive E2F6 Complex Containing the Polycomb Group Protein, EPC1, That Interacts with EZH2 in a Proliferation-specific Manner.
C. Attwooll, S. Oddi, P. Cartwright, E. Prosperini, K. Agger, P. Steensgaard, C. Wagener, C. Sardet, M. C. Moroni, and K. Helin (2005)
J. Biol. Chem.
280, 1199-1208
|Abstract »|Full Text »|PDF »
Regulation of the Arf/p53 Tumor Surveillance Network by E2F.
P.J. IAQUINTA, A. ASLANIAN, and J.A. LEES (2005)
Cold Spring Harb Symp Quant Biol
70, 309-316
|Abstract »|PDF »
Nuclear Speckle-Associated Protein Pnn/DRS Binds to the Transcriptional Corepressor CtBP and Relieves CtBP- Mediated Repression of the E-Cadherin Gene.
R. Alpatov, G. C. Munguba, P. Caton, J. H. Joo, Y. Shi, Y. Shi, M. E. Hunt, and S. P. Sugrue (2004)
Mol. Cell. Biol.
24, 10223-10235
|Abstract »|Full Text »|PDF »
Increased expression of Drosophila Su(var)3-7 triggers Su(var)3-9-dependent heterochromatin formation.
M. Delattre, A. Spierer, Y. Jaquet, and P. Spierer (2004)
J. Cell Sci.
117, 6239-6247
|Abstract »|Full Text »|PDF »
A role for E2F6 in distinguishing G1/S- and G2/M-specific transcription.
P. H. Giangrande, W. Zhu, S. Schlisio, X. Sun, S. Mori, S. Gaubatz, and J. R. Nevins (2004)
Genes & Dev.
18, 2941-2951
|Abstract »|Full Text »|PDF »
Identification of a Drosophila Myb-E2F2/RBF transcriptional repressor complex.
P. W. Lewis, E. L. Beall, T. C. Fleischer, D. Georlette, A. J. Link, and M. R. Botchan (2004)
Genes & Dev.
18, 2929-2940
|Abstract »|Full Text »|PDF »
Therapeutic opportunities for cell cycle re-entry and cardiac regeneration.
K. M. Regula, M. J. Rzeszutek, D. Baetz, C. Seneviratne, and L. A. Kirshenbaum (2004)
Cardiovasc Res
64, 395-401
|Abstract »|Full Text »|PDF »
TIF1{delta}, a Novel HP1-interacting Member of the Transcriptional Intermediary Factor 1 (TIF1) Family Expressed by Elongating Spermatids.
K. Khetchoumian, M. Teletin, M. Mark, T. Lerouge, M. Cervino, M. Oulad-Abdelghani, P. Chambon, and R. Losson (2004)
J. Biol. Chem.
279, 48329-48341
|Abstract »|Full Text »|PDF »
TIN2 Binds TRF1 and TRF2 Simultaneously and Stabilizes the TRF2 Complex on Telomeres.
J. Z.-S. Ye, J. R. Donigian, M. van Overbeek, D. Loayza, Y. Luo, A. N. Krutchinsky, B. T. Chait, and T. de Lange (2004)
J. Biol. Chem.
279, 47264-47271
|Abstract »|Full Text »|PDF »
p55, the Drosophila Ortholog of RbAp46/RbAp48, Is Required for the Repression of dE2F2/RBF-Regulated Genes.
B. Taylor-Harding, U. K. Binne, M. Korenjak, A. Brehm, and N. J. Dyson (2004)
Mol. Cell. Biol.
24, 9124-9136
|Abstract »|Full Text »|PDF »
E2F-1 Regulates the Expression of a Subset of Target Genes during Skeletal Myoblast Hypertrophy.
M. Hlaing, P. Spitz, K. Padmanabhan, B. Cabezas, C. S. Barker, and H. S. Bernstein (2004)
J. Biol. Chem.
279, 43625-43633
|Abstract »|Full Text »|PDF »
In silico identification of transcriptional regulators associated with c-Myc.
R. Elkon, K. I. Zeller, C. Linhart, C. V. Dang, R. Shamir, and Y. Shiloh (2004)
Nucleic Acids Res.
32, 4955-4961
|Abstract »|Full Text »|PDF »
Kinetics of regulated protein-protein interactions revealed with firefly luciferase complementation imaging in cells and living animals.
K. E. Luker, M. C. P. Smith, G. D. Luker, S. T. Gammon, H. Piwnica-Worms, and D. Piwnica-Worms (2004)
PNAS
101, 12288-12293
|Abstract »|Full Text »|PDF »
Reprogramming of a melanoma genome by nuclear transplantation.
K. Hochedlinger, R. Blelloch, C. Brennan, Y. Yamada, M. Kim, L. Chin, and R. Jaenisch (2004)
Genes & Dev.
18, 1875-1885
|Abstract »|Full Text »|PDF »
POT1-interacting protein PIP1: a telomere length regulator that recruits POT1 to the TIN2/TRF1 complex.
J. Z.-S. Ye, D. Hockemeyer, A. N. Krutchinsky, D. Loayza, S. M. Hooper, B. T. Chait, and T. de Lange (2004)
Genes & Dev.
18, 1649-1654
|Abstract »|Full Text »|PDF »
Molecular mechanisms of E2F-dependent activation and pRB-mediated repression.
Identification of Target Genes of the p16INK4A-pRB-E2F Pathway.
R. Vernell, K. Helin, and H. Muller (2003)
J. Biol. Chem.
278, 46124-46137
|Abstract »|Full Text »|PDF »
Pinin/DRS/memA Interacts with SRp75, SRm300 and SRrp130 in Corneal Epithelial Cells.
G. Zimowska, J. Shi, G. Munguba, M. R. Jackson, R. Alpatov, M. N. Simmons, Y. Shi, and S. P. Sugrue (2003)
Invest. Ophthalmol. Vis. Sci.
44, 4715-4723
|Abstract »|Full Text »|PDF »
Identification and Characterization of E2F7, a Novel Mammalian E2F Family Member Capable of Blocking Cellular Proliferation.
A. de Bruin, B. Maiti, L. Jakoi, C. Timmers, R. Buerki, and G. Leone (2003)
J. Biol. Chem.
278, 42041-42049
|Abstract »|Full Text »|PDF »
E2F6 Negatively Regulates BRCA1 in Human Cancer Cells without Methylation of Histone H3 on Lysine 9.
M. J. Oberley, D. R. Inman, and P. J. Farnham (2003)
J. Biol. Chem.
278, 42466-42476
|Abstract »|Full Text »|PDF »
Insulation of the Chicken {beta}-Globin Chromosomal Domain from a Chromatin-Condensing Protein, MENT.
N. E. Istomina, S. S. Shushanov, E. M. Springhetti, V. L. Karpov, I. A. Krasheninnikov, K. Stevens, K. S. Zaret, P. B. Singh, and S. A. Grigoryev (2003)
Mol. Cell. Biol.
23, 6455-6468
|Abstract »|Full Text »|PDF »
Novel Drosophila Heterochromatin Protein 1 (HP1)/Origin Recognition Complex-associated Protein (HOAP) Repeat Motif in HP1/HOAP Interactions and Chromocenter Associations.
R. Badugu, M. M. Shareef, and R. Kellum (2003)
J. Biol. Chem.
278, 34491-34498
|Abstract »|Full Text »|PDF »
Dynamic Recruitment of NF-Y and Histone Acetyltransferases on Cell-cycle Promoters.
G. Caretti, V. Salsi, C. Vecchi, C. Imbriano, and R. Mantovani (2003)
J. Biol. Chem.
278, 30435-30440
|Abstract »|Full Text »|PDF »
Constitutive E2F Expression in Tobacco Plants Exhibits Altered Cell Cycle Control and Morphological Change in a Cell Type-Specific Manner.
Identification of E-Box Factor TFE3 as a Functional Partner for the E2F3 Transcription Factor.
P. H. Giangrande, T. C. Hallstrom, C. Tunyaplin, K. Calame, and J. R. Nevins (2003)
Mol. Cell. Biol.
23, 3707-3720
|Abstract »|Full Text »|PDF »
An epigenetic road map for histone lysine methylation.
M. Lachner, R. J. O'Sullivan, and T. Jenuwein (2003)
J. Cell Sci.
116, 2117-2124
|Full Text »|PDF »
A Genome Scan to Detect Candidate Regions Influenced by Local Natural Selection in Human Populations.
M. Kayser, S. Brauer, and M. Stoneking (2003)
Mol. Biol. Evol.
20, 893-900
|Abstract »|Full Text »|PDF »
Defective Gene Expression, S Phase Progression, and Maturation during Hematopoiesis in E2F1/E2F2 Mutant Mice.
F. X. Li, J. W. Zhu, C. J. Hogan, and J. DeGregori (2003)
Mol. Cell. Biol.
23, 3607-3622
|Abstract »|Full Text »|PDF »
Genomic binding by the Drosophila Myc, Max, Mad/Mnt transcription factor network.
A. Orian, B. van Steensel, J. Delrow, H. J. Bussemaker, L. Li, T. Sawado, E. Williams, L. W.M. Loo, S. M. Cowley, C. Yost, et al. (2003)
Genes & Dev.
17, 1101-1114
|Abstract »|Full Text »|PDF »
Impairment of the DNA Binding Activity of the TATA-binding Protein Renders the Transcriptional Function of Rvb2p/Tih2p, the Yeast RuvB-like Protein, Essential for Cell Growth.
H. Ohdate, C. R. Lim, T. Kokubo, K. Matsubara, Y. Kimata, and K. Kohno (2003)
J. Biol. Chem.
278, 14647-14656
|Abstract »|Full Text »|PDF »
NPAT Expression Is Regulated by E2F and Is Essential for Cell Cycle Progression.
G. Gao, A. P. Bracken, K. Burkard, D. Pasini, M. Classon, C. Attwooll, M. Sagara, T. Imai, K. Helin, and J. Zhao (2003)
Mol. Cell. Biol.
23, 2821-2833
|Abstract »|Full Text »|PDF »
Targeted recruitment of a histone H4-specific methyltransferase by the transcription factor YY1.
N. Rezai-Zadeh, X. Zhang, F. Namour, G. Fejer, Y.-D. Wen, Y.-L. Yao, I. Gyory, K. Wright, and E. Seto (2003)
Genes & Dev.
17, 1019-1029
|Abstract »|Full Text »|PDF »
Induction of "Antigen Silencing" in Melanomas by Oncostatin M: Down-Modulation of Melanocyte Antigen Expression.
P. J. Durda, I. S. Dunn, L. B. Rose, D. Butera, E. M. Benson, F. Pandolfi, and J. T. Kurnick (2003)
Mol. Cancer Res.
1, 411-419
|Abstract »|Full Text »|PDF »
Cell Cycle Modulation of Gene Targeting by a Triple Helix-forming Oligonucleotide.
A. Majumdar, N. Puri, B. Cuenoud, F. Natt, P. Martin, A. Khorlin, N. Dyatkina, A. J. George, P. S. Miller, and M. M. Seidman (2003)
J. Biol. Chem.
278, 11072-11077
|Abstract »|Full Text »|PDF »
G1 cyclin-dependent kinases are insufficient to reverse dE2F2-mediated repression.
M. V. Frolov, O. Stevaux, N.-S. Moon, D. Dimova, E.-J. Kwon, E. J. Morris, and N. J. Dyson (2003)
Genes & Dev.
17, 723-728
|Abstract »|Full Text »|PDF »
, and Polycomb group (PcG) proteins. The
E2F-6 complex preferentially occupies target promoters in G0 cells rather than in G1 cells. These data
suggest that these chromatin modifiers contribute to silencing of E2F-
and Myc-responsive genes in quiescent cells.
