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Science 26 April 2002:
Vol. 296. no. 5568, pp. 747 - 749
DOI: 10.1126/science.1069639
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Reports

A Role for Skin gamma &dgr; T Cells in Wound Repair

Julie Jameson,1 Karen Ugarte,1 Nicole Chen,1 Pia Yachi,1 Elaine Fuchs,2 Richard Boismenu,1 Wendy L. Havran1*

gamma delta T cell receptor-bearing dendritic epidermal T cells (DETCs) found in murine skin recognize antigen expressed by damaged or stressed keratinocytes. Activated DETCs produce keratinocyte growth factors (KGFs) and chemokines, raising the possibility that DETCs play a role in tissue repair. We performed wound healing studies and found defects in keratinocyte proliferation and tissue reepithelialization in the absence of wild-type DETCs. In vitro skin organ culture studies demonstrated that adding DETCs or recombinant KGF restored normal wound healing in gamma delta DETC-deficient skin. We propose that DETCs recognize antigen expressed by injured keratinocytes and produce factors that directly affect wound repair.

1 Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA.
2 Department of Molecular Genetics and Cell Biology, Howard Hughes Medical Institute, The University of Chicago, Chicago, IL 60637, USA.
*   To whom correspondence should be addressed. E-mail: havran{at}scripps.edu

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