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Science 26 April 2002:
Vol. 296. no. 5568, pp. 739 - 741
DOI: 10.1126/science.1069914
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Reports

No Major Schizophrenia Locus Detected on Chromosome 1q in a Large Multicenter Sample

Douglas F. Levinson,1* Peter A. Holmans,2 Claudine Laurent,3 Brien Riley,4 Ann E. Pulver,5 Pablo V. Gejman,6 Sibylle G. Schwab,7 Nigel M. Williams,8 Michael J. Owen,8 Dieter B. Wildenauer,7 Alan R. Sanders,6 Gerald Nestadt,5 Bryan J. Mowry,910 Brandon Wormley,4 Stéphanie Bauché,3 Stéphane Soubigou,11 Robert Ribble,4 Deborah A. Nertney,9 Kung Yee Liang,12 Laura Martinolich,6 Wolfgang Maier,7 Nadine Norton,8 Hywel Williams,8 Margot Albus,13 Eric B. Carpenter,6 Nicola deMarchi,14 Kelly R. Ewen-White,15 Dermot Walsh,16 Maurice Jay,3 Jean-François Deleuze,11 F. Anthony O'Neill,17 George Papadimitriou,18 Ann Weilbaecher,6 Bernard Lerer,19 Michael C. O'Donovan,8 Dimitris Dikeos,18 Jeremy M. Silverman,20 Kenneth S. Kendler,4 Jacques Mallet,3 Raymond R. Crowe,21 Marilyn Walters22

Reports of substantial evidence for genetic linkage of schizophrenia to chromosome 1q were evaluated by genotyping 16 DNA markers across 107 centimorgans of this chromosome in a multicenter sample of 779 informative schizophrenia pedigrees. No significant evidence was observed for such linkage, nor for heterogeneity in allele sharing among the eight individual samples. Separate analyses of European-origin families, recessive models of inheritance, and families with larger numbers of affected cases also failed to produce significant evidence for linkage. If schizophrenia susceptibility genes are present on chromosome 1q, their population-wide genetic effects are likely to be small.

1 Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA.
2 MRC Biostatistics Unit, Cambridge CB2 2SR, UK.
3 Laboratoire de Génétique Moléculaire de la Neurotransmission et des Processus Neurodégénératifs, CNRS, Hôpital de la Pitié Salpêtrière, Paris 75013, France.
4 Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Virginia Commonwealth University, Richmond, VA 23298, USA.
5 Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.
6 Department of Psychiatry, University of Chicago, Chicago, IL 60637, USA.
7 Department of Psychiatry, University of Bonn, D-53105 Bonn, Germany.
8 Department of Psychological Medicine, University of Wales College of Medicine, Cardiff CF14 4XN, UK.
9 Queensland Centre for Schizophrenia Research, Wolston Park Hospital, Wacol 4076, Queensland, Australia.
10 Department of Psychiatry, University of Queensland, Brisbane 4029, Queensland, Australia.
11 Aventis Pharma SA, Evry 91006, France.
12 Department of Biostatistics, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 21231, USA.
13 State Mental Hospital, D-85529 Haar, Germany.
14 Clinica Psichiatrica, Seconda Universita degli Studi di Napoli, Naples 80138, Italy.
15 Australian Genome Research Facility, Walter & Eliza Hall Institute of Medical Research, Melbourne, Victoria 3050, Australia.
16 The Health Research Board, Dublin 2, Ireland.
17 Department of Psychiatry, Queens University, Belfast BT7 1NN, Northern Ireland.
18 Department of Psychiatry, University of Athens Medical School, Athens 11526, Greece.
19 Department of Psychiatry, Hadassah-Hebrew University Medical Center, 91120 Jerusalem, Israel.
20 Department of Psychiatry, Mt. Sinai School of Medicine, New York, NY 10029, USA.
21 Mental Health Clinical Research Center and Department of Psychiatry, University of Iowa College of Medicine, Iowa City, IA 52242, USA.
22 Queensland Institute of Medical Research, Herston 4006, Queensland, Australia.
*   To whom correspondence should be addressed. E-mail: dfl{at}mail.med.upenn.edu

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