Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 5 April 2002:
Vol. 296. no. 5565, pp. 155 - 158
DOI: 10.1126/science.1069659
Prev | Table of Contents | Next

Reports

Resolution of Lung Inflammation by CD44

Priit Teder,1 R. William Vandivier,2 Dianhua Jiang,1 Jiurong Liang,1 Lauren Cohn,1 Ellen Puré,3 Peter M. Henson,2 Paul W. Noble1*

Successful repair after tissue injury and inflammation requires resolution of the inflammatory response and removal of extracellular matrix breakdown products. We have examined whether the cell-surface adhesion molecule and hyaluronan receptor CD44 plays a role in resolving lung inflammation. CD44-deficient mice succumb to unremitting inflammation following noninfectious lung injury, characterized by impaired clearance of apoptotic neutrophils, persistent accumulation of hyaluronan fragments at the site of tissue injury, and impaired activation of transforming growth factor-beta 1. This phenotype was partially reversed by reconstitution with CD44+ cells, thus demonstrating a critical role for this receptor in resolving lung inflammation.

1 Department of Medicine, Pulmonary and Critical Care Section, Yale University School of Medicine, New Haven, CT 06520, and VA Connecticut Healthcare System, West Haven, CT 06516, USA.
2 Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA.
3 Wistar Institute, Philadelphia, PA 19104, and The Ludwig Institute for Cancer Research, New York, NY 10158, USA.
*   To whom correspondence should be addressed. E-mail: paul.noble{at}yale.edu

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Modulation of Hyaluronan Synthase Activity in Cellular Membrane Fractions.
D. Vigetti, A. Genasetti, E. Karousou, M. Viola, M. Clerici, B. Bartolini, P. Moretto, G. De Luca, V. C. Hascall, and A. Passi (2009)
J. Biol. Chem. 284, 30684-30694
   Abstract »    Full Text »    PDF »
Dysfunctional cystic fibrosis transmembrane conductance regulator inhibits phagocytosis of apoptotic cells with proinflammatory consequences.
R. W. Vandivier, T. R. Richens, S. A. Horstmann, A. M. deCathelineau, M. Ghosh, S. D. Reynolds, Y.-Q. Xiao, D. W. Riches, J. Plumb, E. Vachon, et al. (2009)
Am J Physiol Lung Cell Mol Physiol 297, L677-L686
   Abstract »    Full Text »    PDF »
Decreased hyaluronan in airway smooth muscle cells from patients with asthma and COPD.
I. Klagas, S. Goulet, G. Karakiulakis, J. Zhong, M. Baraket, J. L. Black, E. Papakonstantinou, and M. Roth (2009)
Eur. Respir. J. 34, 616-628
   Abstract »    Full Text »    PDF »
Involvement of Hyaluronan and Its Receptor CD44 with Choroidal Neovascularization.
H. Mochimaru, E. Takahashi, N. Tsukamoto, J. Miyazaki, T. Yaguchi, T. Koto, T. Kurihara, K. Noda, Y. Ozawa, T. Ishimoto, et al. (2009)
Invest. Ophthalmol. Vis. Sci. 50, 4410-4415
   Abstract »    Full Text »    PDF »
CD44 Costimulation Promotes FoxP3+ Regulatory T Cell Persistence and Function via Production of IL-2, IL-10, and TGF-{beta}.
P. L. Bollyky, B. A. Falk, S. A. Long, A. Preisinger, K. R. Braun, R. P. Wu, S. P. Evanko, J. H. Buckner, T. N. Wight, and G. T. Nepom (2009)
J. Immunol. 183, 2232-2241
   Abstract »    Full Text »    PDF »
Cigarette Smoke Impairs Clearance of Apoptotic Cells through Oxidant-dependent Activation of RhoA.
T. R. Richens, D. J. Linderman, S. A. Horstmann, C. Lambert, Y.-Q. Xiao, R. L. Keith, D. M. Boe, K. Morimoto, R. P. Bowler, B. J. Day, et al. (2009)
Am. J. Respir. Crit. Care Med. 179, 1011-1021
   Abstract »    Full Text »    PDF »
Isolation of murine lung endothelial cells.
M. L. Fehrenbach, G. Cao, J. T. Williams, J. M. Finklestein, and H. M. DeLisser (2009)
Am J Physiol Lung Cell Mol Physiol 296, L1096-L1103
   Abstract »    Full Text »    PDF »
Platelet-Derived Hyaluronidase 2 Cleaves Hyaluronan into Fragments that Trigger Monocyte-Mediated Production of Proinflammatory Cytokines.
C. de la Motte, J. Nigro, A. Vasanji, H. Rho, S. Kessler, S. Bandyopadhyay, S. Danese, C. Fiocchi, and R. Stern (2009)
Am. J. Pathol. 174, 2254-2264
   Abstract »    Full Text »    PDF »
NLRP3/Cryopyrin Is Necessary for Interleukin-1{beta} (IL-1{beta}) Release in Response to Hyaluronan, an Endogenous Trigger of Inflammation in Response to Injury.
K. Yamasaki, J. Muto, K. R. Taylor, A. L. Cogen, D. Audish, J. Bertin, E. P. Grant, A. J. Coyle, A. Misaghi, H. M. Hoffman, et al. (2009)
J. Biol. Chem. 284, 12762-12771
   Abstract »    Full Text »    PDF »
Hyaluronan Mediates Ozone-induced Airway Hyperresponsiveness in Mice.
S. Garantziotis, Z. Li, E. N. Potts, K. Kimata, L. Zhuo, D. L. Morgan, R. C. Savani, P. W. Noble, W. M. Foster, D. A. Schwartz, et al. (2009)
J. Biol. Chem. 284, 11309-11317
   Abstract »    Full Text »    PDF »
The Adenosine A2a Receptor Inhibits Matrix-Induced Inflammation in a Novel Fashion.
K. A. Scheibner, S. Boodoo, S. Collins, K. E. Black, Y. Chan-Li, P. Zarek, J. D. Powell, and M. R. Horton (2009)
Am. J. Respir. Cell Mol. Biol. 40, 251-259
   Abstract »    Full Text »    PDF »
Primary Murine Airway Smooth Muscle Cells Exposed to Poly(I,C) or Tunicamycin Synthesize a Leukocyte-adhesive Hyaluronan Matrix.
M. E. Lauer, D. Mukhopadhyay, C. Fulop, C. A. de la Motte, A. K. Majors, and V. C. Hascall (2009)
J. Biol. Chem. 284, 5299-5312
   Abstract »    Full Text »    PDF »
Expression of Hyaluronan Synthase 1 and Distribution of Hyaluronan During Follicular Atresia in Pig Ovaries.
Y. Miyake, M. Sakurai, S. Tanaka, W. A. S. Tunjung, M. Yokoo, H. Matsumoto, H. Aso, T. Yamaguchi, and E. Sato (2009)
Biol Reprod 80, 249-257
   Abstract »    Full Text »    PDF »
Increased hyaluronic acid content in idiopathic pulmonary arterial hypertension.
E. Papakonstantinou, F. M. Kouri, G. Karakiulakis, I. Klagas, and O. Eickelberg (2008)
Eur. Respir. J. 32, 1504-1512
   Abstract »    Full Text »    PDF »
Hyaluronan Induces Cell Death in Activated T Cells through CD44.
B. Ruffell and P. Johnson (2008)
J. Immunol. 181, 7044-7054
   Abstract »    Full Text »    PDF »
Serum Inter-{alpha}-Trypsin Inhibitor and Matrix Hyaluronan Promote Angiogenesis in Fibrotic Lung Injury.
S. Garantziotis, E. Zudaire, C. S. Trempus, J. W. Hollingsworth, D. Jiang, L. H. Lancaster, E. Richardson, L. Zhuo, F. Cuttitta, K. K. Brown, et al. (2008)
Am. J. Respir. Crit. Care Med. 178, 939-947
   Abstract »    Full Text »    PDF »
High levels of hyaluronan in idiopathic pulmonary arterial hypertension.
M. Aytekin, S. A. A. Comhair, C. de la Motte, S. K. Bandyopadhyay, C. F. Farver, V. C. Hascall, S. C. Erzurum, and R. A. Dweik (2008)
Am J Physiol Lung Cell Mol Physiol 295, L789-L799
   Abstract »    Full Text »    PDF »
Dysregulation of lung injury and repair in moesin-deficient mice treated with intratracheal bleomycin.
S. Hashimoto, F. Amaya, H. Matsuyama, H. Ueno, S. Kikuchi, M. Tanaka, Y. Watanabe, M. Ebina, A. Ishizaka, S. Tsukita, et al. (2008)
Am J Physiol Lung Cell Mol Physiol 295, L566-L574
   Abstract »    Full Text »    PDF »
Differentiated Murine Airway Epithelial Cells Synthesize a Leukocyte-adhesive Hyaluronan Matrix in Response to Endoplasmic Reticulum Stress.
M. E. Lauer, S. C. Erzurum, D. Mukhopadhyay, A. Vasanji, J. Drazba, A. Wang, C. Fulop, and V. C. Hascall (2008)
J. Biol. Chem. 283, 26283-26296
   Abstract »    Full Text »    PDF »
Cathelicidin Antimicrobial Peptides Inhibit Hyaluronan-Induced Cytokine Release and Modulate Chronic Allergic Dermatitis.
Y. Morioka, K. Yamasaki, D. Leung, and R. L. Gallo (2008)
J. Immunol. 181, 3915-3922
   Abstract »    Full Text »    PDF »
Hyaluronidase Expression and Activity Is Regulated by Pro-Inflammatory Cytokines in Human Airway Epithelial Cells.
M. E. Monzon, D. Manzanares, N. Schmid, S. M. Casalino-Matsuda, and R. M. Forteza (2008)
Am. J. Respir. Cell Mol. Biol. 39, 289-295
   Abstract »    Full Text »    PDF »
Nonredundant Functions of {alpha}{beta} and {gamma}{delta} T Cells in Acrolein-Induced Pulmonary Pathology.
M. T. Borchers, S. C. Wesselkamper, B. L. Eppert, G. T. Motz, M. A. Sartor, C. R. Tomlinson, M. Medvedovic, and J. W. Tichelaar (2008)
Toxicol. Sci. 105, 188-199
   Abstract »    Full Text »    PDF »
Tracking the Toll of Kidney Disease.
A. C. Shirali and D. R. Goldstein (2008)
J. Am. Soc. Nephrol. 19, 1444-1450
   Abstract »    Full Text »    PDF »
Hyaluronan Constitutively Regulates Activation of COX-2-mediated Cell Survival Activity in Intestinal Epithelial and Colon Carcinoma Cells.
S. Misra, L. M. Obeid, Y. A. Hannun, S. Minamisawa, F. G. Berger, R. R. Markwald, B. P. Toole, and S. Ghatak (2008)
J. Biol. Chem. 283, 14335-14344
   Abstract »    Full Text »    PDF »
Fibroblast migration is mediated by CD44-dependent TGF{beta} activation.
P. S. Acharya, S. Majumdar, M. Jacob, J. Hayden, P. Mrass, W. Weninger, R. K. Assoian, and E. Pure (2008)
J. Cell Sci. 121, 1393-1402
   Abstract »    Full Text »    PDF »
CD44 Suppresses TLR-Mediated Inflammation.
H. Kawana, H. Karaki, M. Higashi, M. Miyazaki, F. Hilberg, M. Kitagawa, and K. Harigaya (2008)
J. Immunol. 180, 4235-4245
   Abstract »    Full Text »    PDF »
An Essential Role for Fibronectin Extra Type III Domain A in Pulmonary Fibrosis.
A. F. Muro, F. A. Moretti, B. B. Moore, M. Yan, R. G. Atrasz, C. A. Wilke, K. R. Flaherty, F. J. Martinez, J. L. Tsui, D. Sheppard, et al. (2008)
Am. J. Respir. Crit. Care Med. 177, 638-645
   Abstract »    Full Text »    PDF »
Extracellular Superoxide Dismutase Inhibits Inflammation by Preventing Oxidative Fragmentation of Hyaluronan.
F. Gao, J. R. Koenitzer, J. M. Tobolewski, D. Jiang, J. Liang, P. W. Noble, and T. D. Oury (2008)
J. Biol. Chem. 283, 6058-6066
   Abstract »    Full Text »    PDF »
CD44 Is Critically Involved in Infarct Healing by Regulating the Inflammatory and Fibrotic Response.
P. Huebener, T. Abou-Khamis, P. Zymek, M. Bujak, X. Ying, K. Chatila, S. Haudek, G. Thakker, and N. G. Frangogiannis (2008)
J. Immunol. 180, 2625-2633
   Abstract »    Full Text »    PDF »
Regulation of Alternative Macrophage Activation by Galectin-3.
A. C. MacKinnon, S. L. Farnworth, P. S. Hodkinson, N. C. Henderson, K. M. Atkinson, H. Leffler, U. J. Nilsson, C. Haslett, S. J. Forbes, and T. Sethi (2008)
J. Immunol. 180, 2650-2658
   Abstract »    Full Text »    PDF »
Macrophage Migration Inhibitory Factor Induces B Cell Survival by Activation of a CD74-CD44 Receptor Complex.
Y. Gore, D. Starlets, N. Maharshak, S. Becker-Herman, U. Kaneyuki, L. Leng, R. Bucala, and I. Shachar (2008)
J. Biol. Chem. 283, 2784-2792
   Abstract »    Full Text »    PDF »
Smoking Alters Alveolar Macrophage Recognition and Phagocytic Ability: Implications in Chronic Obstructive Pulmonary Disease.
S. Hodge, G. Hodge, J. Ahern, H. Jersmann, M. Holmes, and P. N. Reynolds (2007)
Am. J. Respir. Cell Mol. Biol. 37, 748-755
   Abstract »    Full Text »    PDF »
CD44 Regulates Hepatocyte Growth Factor-mediated Vascular Integrity: ROLE OF c-Met, Tiam1/Rac1, DYNAMIN 2, AND CORTACTIN.
P. A. Singleton, R. Salgia, L. Moreno-Vinasco, J. Moitra, S. Sammani, T. Mirzapoiazova, and J. G. N. Garcia (2007)
J. Biol. Chem. 282, 30643-30657
   Abstract »    Full Text »    PDF »
Fas-induced Pulmonary Apoptosis and Inflammation during Indirect Acute Lung Injury.
M. Perl, C.-S. Chung, U. Perl, J. Lomas-Neira, M. de Paepe, W. G. Cioffi, and A. Ayala (2007)
Am. J. Respir. Crit. Care Med. 176, 591-601
   Abstract »    Full Text »    PDF »
To Live and Die in the LA (Lung Airway): Mode of Neutrophil Death and Progression of Chronic Obstructive Pulmonary Disease.
N. Minematsu and S. D. Shapiro (2007)
Am. J. Respir. Cell Mol. Biol. 37, 129-130
   Full Text »    PDF »
CD44 Regulates Macrophage Recruitment to the Lung in Lipopolysaccharide-Induced Airway Disease.
J. W. Hollingsworth, Z. Li, D. M. Brass, S. Garantziotis, S. H. Timberlake, A. Kim, I. Hossain, R. C. Savani, and D. A. Schwartz (2007)
Am. J. Respir. Cell Mol. Biol. 37, 248-253
   Abstract »    Full Text »    PDF »
Susceptibility of Hermansky-Pudlak Mice to Bleomycin-Induced Type II Cell Apoptosis and Fibrosis.
L. R. Young, R. Pasula, P. M. Gulleman, G. H. Deutsch, and F. X. McCormack (2007)
Am. J. Respir. Cell Mol. Biol. 37, 67-74
   Abstract »    Full Text »    PDF »
Immunological Consequences of Apoptotic Cell Phagocytosis.
L.-P. Erwig and P. M. Henson (2007)
Am. J. Pathol. 171, 2-8
   Abstract »    Full Text »    PDF »
Interleukin 1 receptor antagonist mediates the antiinflammatory and antifibrotic effect of mesenchymal stem cells during lung injury.
L. A. Ortiz, M. DuTreil, C. Fattman, A. C. Pandey, G. Torres, K. Go, and D. G. Phinney (2007)
PNAS 104, 11002-11007
   Abstract »    Full Text »    PDF »
Recognition of Hyaluronan Released in Sterile Injury Involves a Unique Receptor Complex Dependent on Toll-like Receptor 4, CD44, and MD-2.
K. R. Taylor, K. Yamasaki, K. A. Radek, A. D. Nardo, H. Goodarzi, D. Golenbock, B. Beutler, and R. L. Gallo (2007)
J. Biol. Chem. 282, 18265-18275
   Abstract »    Full Text »    PDF »
GLYCOSAMINOGLYCANS AND PROTEOGLYCANS: OVERLOOKED ENTITIES?.
S. Yung and T. M. Chan (2007)
Perit. Dial. Int. 27, S104-S109
   Abstract »    Full Text »    PDF »
Protective Role of Macrophages in Noninflammatory Lung Injury Caused by Selective Ablation of Alveolar Epithelial Type II Cells.
Y. Miyake, H. Kaise, K.-i. Isono, H. Koseki, K. Kohno, and M. Tanaka (2007)
J. Immunol. 178, 5001-5009
   Abstract »    Full Text »    PDF »
CD44 Is a Negative Regulator of Acute Pulmonary Inflammation and Lipopolysaccharide-TLR Signaling in Mouse Macrophages.
J. Liang, D. Jiang, J. Griffith, S. Yu, J. Fan, X. Zhao, R. Bucala, and P. W. Noble (2007)
J. Immunol. 178, 2469-2475
   Abstract »    Full Text »    PDF »
Mice Lacking Neutrophil Elastase Are Resistant to Bleomycin-Induced Pulmonary Fibrosis.
F. Chua, S. E. Dunsmore, P. H. Clingen, S. E. Mutsaers, S. D. Shapiro, A. W. Segal, J. Roes, and G. J. Laurent (2007)
Am. J. Pathol. 170, 65-74
   Abstract »    Full Text »    PDF »
Functional and genomic changes induced by alveolar transmigration in human neutrophils.
C. D. Coldren, J. A. Nick, K. R. Poch, M. D. Woolum, B. W. Fouty, J. M. O'Brien, M. P. Gruber, M. R. Zamora, D. Svetkauskaite, D. A. Richter, et al. (2006)
Am J Physiol Lung Cell Mol Physiol 291, L1267-L1276
   Abstract »    Full Text »    PDF »
Alveolar macrophages contribute to alveolar barrier dysfunction in ventilator-induced lung injury.
J. A. Frank, C. M. Wray, D. F. McAuley, R. Schwendener, and M. A. Matthay (2006)
Am J Physiol Lung Cell Mol Physiol 291, L1191-L1198
   Abstract »    Full Text »    PDF »
Urothelial CD44 Facilitates Escherichia coli Infection of the Murine Urinary Tract.
K. M. A. Rouschop, M. Sylva, G. J. D. Teske, I. Hoedemaeker, S. T. Pals, J. J. Weening, T. van der Poll, and S. Florquin (2006)
J. Immunol. 177, 7225-7232
   Abstract »    Full Text »    PDF »
Transactivation of Sphingosine 1-Phosphate Receptors Is Essential for Vascular Barrier Regulation: NOVEL ROLE FOR HYALURONAN AND CD44 RECEPTOR FAMILY.
P. A. Singleton, S. M. Dudek, S.-F. Ma, and J. G. N. Garcia (2006)
J. Biol. Chem. 281, 34381-34393
   Abstract »    Full Text »    PDF »
Requirements for Apoptotic Cell Contact in Regulation of Macrophage Responses.
M. Lucas, L. M. Stuart, A. Zhang, K. Hodivala-Dilke, M. Febbraio, R. Silverstein, J. Savill, and A. Lacy-Hulbert (2006)
J. Immunol. 177, 4047-4054
   Abstract »    Full Text »    PDF »
ATP-binding cassette transporter A7 enhances phagocytosis of apoptotic cells and associated ERK signaling in macrophages.
A. W. Jehle, S. J. Gardai, S. Li, P. Linsel-Nitschke, K. Morimoto, W. J. Janssen, R. W. Vandivier, N. Wang, S. Greenberg, B. M. Dale, et al. (2006)
J. Cell Biol. 174, 547-556
   Abstract »    Full Text »    PDF »
SHAP Potentiates the CD44-mediated Leukocyte Adhesion to the Hyaluronan Substratum.
L. Zhuo, A. Kanamori, R. Kannagi, N. Itano, J. Wu, M. Hamaguchi, N. Ishiguro, and K. Kimata (2006)
J. Biol. Chem. 281, 20303-20314
   Abstract »    Full Text »    PDF »
Hyaluronan Fragments Act as an Endogenous Danger Signal by Engaging TLR2.
K. A. Scheibner, M. A. Lutz, S. Boodoo, M. J. Fenton, J. D. Powell, and M. R. Horton (2006)
J. Immunol. 177, 1272-1281
   Abstract »    Full Text »    PDF »
Matrix regulation of lung injury, inflammation, and repair: the role of innate immunity..
P. W. Noble and D. Jiang (2006)
Proceedings of the ATS 3, 401-404
   Abstract »    Full Text »    PDF »
Involvement of Endothelial CD44 during in Vivo Angiogenesis.
G. Cao, R. C. Savani, M. Fehrenbach, C. Lyons, L. Zhang, G. Coukos, and H. M. DeLisser (2006)
Am. J. Pathol. 169, 325-336
   Abstract »    Full Text »    PDF »
Hyaluronan Oligosaccharides Induce Matrix Metalloproteinase 13 via Transcriptional Activation of NF{kappa}B and p38 MAP Kinase in Articular Chondrocytes.
S. Ohno, H.-J. Im, C. B. Knudson, and W. Knudson (2006)
J. Biol. Chem. 281, 17952-17960
   Abstract »    Full Text »    PDF »
Lovastatin enhances clearance of apoptotic cells (efferocytosis) with implications for chronic obstructive pulmonary disease..
K. Morimoto, W. J. Janssen, M. B. Fessler, K. A. McPhillips, V. M. Borges, R. P. Bowler, Y.-Q. Xiao, J. A. Kench, P. M. Henson, and R. W. Vandivier (2006)
J. Immunol. 176, 7657-7665
   Abstract »    Full Text »    PDF »
CD44 is a phagocytic receptor.
E. Vachon, R. Martin, J. Plumb, V. Kwok, R. W. Vandivier, M. Glogauer, A. Kapus, X. Wang, C.-W. Chow, S. Grinstein, et al. (2006)
Blood 107, 4149-4158
   Abstract »    Full Text »    PDF »
Expression and Glycosylation with Polylactosamine of CD44 Antigen on Macrophages During Follicular Atresia in Pig Ovaries.
Y. Miyake, H. Matsumoto, M. Yokoo, K. Miyazawa, N. Kimura, W. A. S. Tunjung, T. Shimizu, H. Sasada, H. Aso, T. Yamaguchi, et al. (2006)
Biol Reprod 74, 501-510
   Abstract »    Full Text »    PDF »
Vascular endothelial growth factor in the lung.
N. F. Voelkel, R. W. Vandivier, and R. M. Tuder (2006)
Am J Physiol Lung Cell Mol Physiol 290, L209-L221
   Abstract »    Full Text »    PDF »
Glycosaminoglycans and their proteoglycans: host-associated molecular patterns for initiation and modulation of inflammation.
K. R. Taylor and R. L. Gallo (2006)
FASEB J 20, 9-22
   Abstract »    Full Text »    PDF »
Role of Eotaxin-1 (CCL11) and CC Chemokine Receptor 3 (CCR3) in Bleomycin-Induced Lung Injury and Fibrosis.
F. Huaux, M. Gharaee-Kermani, T. Liu, V. Morel, B. McGarry, M. Ullenbruch, S. L. Kunkel, J. Wang, Z. Xing, and S. H. Phan (2005)
Am. J. Pathol. 167, 1485-1496
   Abstract »    Full Text »    PDF »
Expression and Role of the Hyaluronan Receptor RHAMM in Inflammation after Bleomycin Injury.
A. Zaman, Z. Cui, J. P. Foley, H. Zhao, P. C. Grimm, H. M. DeLisser, and R. C. Savani (2005)
Am. J. Respir. Cell Mol. Biol. 33, 447-454
   Abstract »    Full Text »    PDF »
The N-terminal Module of Thrombospondin-1 Interacts with the Link Domain of TSG-6 and Enhances Its Covalent Association with the Heavy Chains of Inter-{alpha}-trypsin Inhibitor.
S. A. Kuznetsova, A. J. Day, D. J. Mahoney, M. S. Rugg, D. F. Mosher, and D. D. Roberts (2005)
J. Biol. Chem. 280, 30899-30908
   Abstract »    Full Text »    PDF »
Differential Involvement of Calmodulin-dependent Protein Kinase II-activated AP-1 and c-Jun N-terminal Kinase-activated EGR-1 Signaling Pathways in Tumor Necrosis Factor-{alpha} and Lipopolysaccharide-induced CD44 Expression in Human Monocytic Cells.
J. P. Mishra, S. Mishra, K. Gee, and A. Kumar (2005)
J. Biol. Chem. 280, 26825-26837
   Abstract »    Full Text »    PDF »
Pulmonary Fibrosis: Searching for Model Answers.
F. Chua, J. Gauldie, and G. J. Laurent (2005)
Am. J. Respir. Cell Mol. Biol. 33, 9-13
   Abstract »    Full Text »    PDF »
Expression of N-acetylglucosamine 6-O-sulfotransferases (GlcNAc6STs)-1 and -4 in human monocytes: GlcNAc6ST-1 is implicated in the generation of the 6-sulfo N-acetyllactosamine/Lewis x epitope on CD44 and is induced by TNF-{alpha}.
S. L. Tjew, K. L. Brown, R. Kannagi, and P. Johnson (2005)
Glycobiology 15, 7C-13C
   Abstract »    Full Text »    PDF »
Inhibition of Macrophage Nuclear Factor-{kappa}B Leads to a Dominant Anti-Inflammatory Phenotype that Attenuates Glomerular Inflammation in Vivo.
H. M. Wilson, S. Chettibi, C. Jobin, D. Walbaum, A. J. Rees, and D. C. Kluth (2005)
Am. J. Pathol. 167, 27-37
   Abstract »    Full Text »    PDF »
Protection against Renal Ischemia Reperfusion Injury by CD44 Disruption.
K. M. A. Rouschop, J. J.T.H. Roelofs, N. Claessen, P. d. C. Martins, J.-J. Zwaginga, S. T. Pals, J. J. Weening, and S. Florquin (2005)
J. Am. Soc. Nephrol. 16, 2034-2043
   Abstract »    Full Text »    PDF »
CD44 is a physiological E-selectin ligand on neutrophils.
Y. Katayama, A. Hidalgo, J. Chang, A. Peired, and P. S. Frenette (2005)
J. Exp. Med. 201, 1183-1189
   Abstract »    Full Text »    PDF »
Phenotypic characterisation of alveolar macrophages and peripheral blood monocytes in COPD.
A. R. Pons, A. Noguera, D. Blanquer, J. Sauleda, J. Pons, and A. G. N. Agusti (2005)
Eur. Respir. J. 25, 647-652
   Abstract »    Full Text »    PDF »
CD44 is a determinant of inflammatory bone loss.
S. Hayer, G. Steiner, B. Gortz, E. Reiter, M. Tohidast-Akrad, M. Amling, O. Hoffmann, K. Redlich, J. Zwerina, K. Skriner, et al. (2005)
J. Exp. Med. 201, 903-914
   Abstract »    Full Text »    PDF »
RHAMM, a receptor for hyaluronan-mediated motility, compensates for CD44 in inflamed CD44-knockout mice: A different interpretation of redundancy.
S. Nedvetzki, E. Gonen, N. Assayag, R. Reich, R. O. Williams, R. L. Thurmond, J.-F. Huang, B. A. Neudecker, F.-S. Wang, E. A. Turley, et al. (2004)
PNAS 101, 18081-18086
   Abstract »    Full Text »    PDF »
Role of CD44 and Hyaluronan in Neutrophil Recruitment.
A. I. Khan, S. M. Kerfoot, B. Heit, L. Liu, G. Andonegui, B. Ruffell, P. Johnson, and P. Kubes (2004)
J. Immunol. 173, 7594-7601
   Abstract »    Full Text »    PDF »
Rapid Plasma Membrane-Endosomal Trafficking of the Lymph Node Sinus and High Endothelial Venule Scavenger Receptor/Homing Receptor Stabilin-1 (Feel-1/Clever-1).
R. Prevo, S. Banerji, J. Ni, and D. G. Jackson (2004)
J. Biol. Chem. 279, 52580-52592
   Abstract »    Full Text »    PDF »
Apoptosis in lung injury and remodeling.
X. Li, R. Shu, G. Filippatos, and B. D. Uhal (2004)
J Appl Physiol 97, 1535-1542
   Abstract »    Full Text »    PDF »
Pro- and Anti-Inflammatory Factors Cooperate to Control Hyaluronan Synthesis in Lung Fibroblasts.
T. S. Wilkinson, S. Potter-Perigo, C. Tsoi, L. C. Altman, and T. N. Wight (2004)
Am. J. Respir. Cell Mol. Biol. 31, 92-99
   Abstract »    Full Text »    PDF »
Expression of L-Selectin, but Not CD44, Is Required for Early Neutrophil Extravasation in Antigen-Induced Arthritis.
S. Szanto, I. Gal, A. Gonda, T. T. Glant, and K. Mikecz (2004)
J. Immunol. 172, 6723-6734
   Abstract »    Full Text »    PDF »
Cysteinyl leukotriene 1 receptor controls the severity of chronic pulmonary inflammation and fibrosis.
T. C. Beller, D. S. Friend, A. Maekawa, B. K. Lam, K. F. Austen, and Y. Kanaoka (2004)
PNAS 101, 3047-3052
   Abstract »    Full Text »    PDF »
CD44 Deficiency Increases Tubular Damage But Reduces Renal Fibrosis in Obstructive Nephropathy.
K. M.A. Rouschop, M. E. Sewnath, N. Claessen, J. J.T.H. Roelofs, I. Hoedemaeker, R. van der Neut, J. Aten, S. T. Pals, J. J. Weening, and S. Florquin (2004)
J. Am. Soc. Nephrol. 15, 674-686
   Abstract »    Full Text »    PDF »
The role of the CD44 transmembrane and cytoplasmic domains in co-ordinating adhesive and signalling events.
R. F. Thorne, J. W. Legg, and C. M. Isacke (2004)
J. Cell Sci. 117, 373-380
   Abstract »    Full Text »    PDF »
Hyaluronan-oligosaccharide-induced transcription of metalloproteases.
C. Fieber, P. Baumann, R. Vallon, C. Termeer, J. C. Simon, M. Hofmann, P. Angel, P. Herrlich, and J. P. Sleeman (2004)
J. Cell Sci. 117, 359-367
   Abstract »    Full Text »    PDF »
Hyaluronic Acid or TNF-{alpha} Plus Fibronectin Triggers Granulocyte Macrophage-Colony-Stimulating Factor mRNA Stabilization in Eosinophils Yet Engages Differential Intracellular Pathways and mRNA Binding Proteins.
S. Esnault and J. S. Malter (2003)
J. Immunol. 171, 6780-6787
   Abstract »    Full Text »    PDF »
Increased neutrophil influx but no impairment of protective immunity to tuberculosis in mice lacking the CD44 molecule.
A. Kipnis, R. J. Basaraba, J. Turner, and I. M. Orme (2003)
J. Leukoc. Biol. 74, 992-997
   Abstract »    Full Text »
Temporal dynamics of recurrent airway symptoms and cellular random walk.
B. Suki and U. Frey (2003)
J Appl Physiol 95, 2122-2127
   Abstract »    Full Text »    PDF »
Involvement of Serum Response Factor Isoforms in Myofibroblast Differentiation During Bleomycin-Induced Lung Injury.
Y. Yang, X. Zhe, S. H. Phan, M. Ullenbruch, and L. Schuger (2003)
Am. J. Respir. Cell Mol. Biol. 29, 583-590
   Abstract »    Full Text »
Idiopathic Pulmonary Fibrosis: The Inflammation Hypothesis Revisited.
D. W. Kamp (2003)
Chest 124, 1187-1190
   Full Text »    PDF »
Tumor Necrosis Factor-{alpha} Induces Functionally Active Hyaluronan-adhesive CD44 by Activating Sialidase through p38 Mitogen-activated Protein Kinase in Lipopolysaccharide-stimulated Human Monocytic Cells.
K. Gee, M. Kozlowski, and A. Kumar (2003)
J. Biol. Chem. 278, 37275-37287
   Abstract »    Full Text »    PDF »
Idiopathic Pulmonary Fibrosis.
N. Kaminski, J. A. Belperio, P. B. Bitterman, L. Chen, S. W. Chensue, A. M.K. Choi, S. Dacic, J. H. Dauber, R. M. du Bois, J. J. Enghild, et al. (2003)
Am. J. Respir. Cell Mol. Biol. 29, S1-105
   Full Text »    PDF »
Mesenchymal stem cell engraftment in lung is enhanced in response to bleomycin exposure and ameliorates its fibrotic effects.
L. A. Ortiz, F. Gambelli, C. McBride, D. Gaupp, M. Baddoo, N. Kaminski, and D. G. Phinney (2003)
PNAS 100, 8407-8411
   Abstract »    Full Text »    PDF »
Appetizing rancidity of apoptotic cells for macrophages: oxidation, externalization, and recognition of phosphatidylserine.
V. E. Kagan, G. G. Borisenko, B. F. Serinkan, Y. Y. Tyurina, V. A. Tyurin, J. Jiang, S. X. Liu, A. A. Shvedova, J. P. Fabisiak, W. Uthaisang, et al. (2003)
Am J Physiol Lung Cell Mol Physiol 285, L1-L17
   Abstract »    Full Text »    PDF »
Microarray Analysis and RNA Silencing Link fra-1 to cd44 and c-met Expression in Mesothelioma.
M. E. Ramos-Nino, L. Scapoli, M. Martinelli, S. Land, and B. T. Mossman (2003)
Cancer Res. 63, 3539-3545
   Abstract »    Full Text »    PDF »
The liberation of CD44.
J. Cichy and E. Pure (2003)
J. Cell Biol. 161, 839-843
   Abstract »    Full Text »    PDF »
Hyaluronan in Respiratory Injury and Repair.
G. M. Turino and J. O. Cantor (2003)
Am. J. Respir. Crit. Care Med. 167, 1169-1175
   Full Text »    PDF »
CD44-stimulated human B cells express transcripts specifically involved in immunomodulation and inflammation as analyzed by DNA microarrays.
C.-M. Hogerkorp, S. Bilke, T. Breslin, S. Ingvarsson, and C. A. K. Borrebaeck (2003)
Blood 101, 2307-2313
   Abstract »    Full Text »    PDF »
Dual Roles of IL-4 in Lung Injury and Fibrosis.
F. Huaux, T. Liu, B. McGarry, M. Ullenbruch, and S. H. Phan (2003)
J. Immunol. 170, 2083-2092
   Abstract »    Full Text »    PDF »
CD44 Deficiency Leads to Enhanced Neutrophil Migration and Lung Injury in Escherichia coli Pneumonia in Mice.
Q. Wang, P. Teder, N. P. Judd, P. W. Noble, and C. M. Doerschuk (2002)
Am. J. Pathol. 161, 2219-2228
   Abstract »    Full Text »    PDF »
NF-kappa B Activation Mediates the Cross-talk between Extracellular Matrix and Interferon-gamma (IFN-gamma ) Leading to Enhanced Monokine Induced by IFN-gamma (MIG) Expression in Macrophages.
M. R. Horton, S. Boodoo, and J. D. Powell (2002)
J. Biol. Chem. 277, 43757-43762
   Abstract »    Full Text »    PDF »
Proteinase-mediated Release of Epithelial Cell-associated CD44. EXTRACELLULAR CD44 COMPLEXES WITH COMPONENTS OF CELLULAR MATRICES.
J. Cichy, R. Bals, J. Potempa, A. Mani, and E. Pure (2002)
J. Biol. Chem. 277, 44440-44447
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)