Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 29 March 2002:
Vol. 295. no. 5564, pp. 2387 - 2392
DOI: 10.1126/science.1067100
Prev | Table of Contents | Next

Review

Matrix Metalloproteinase Inhibitors and Cancer—Trials and Tribulations

Lisa M. Coussens,1 Barbara Fingleton,2 Lynn M. Matrisian2*

For at least 30 years, matrix metalloproteinases (MMPs) have been heralded as promising targets for cancer therapy on the basis of their massive up-regulation in malignant tissues and their unique ability to degrade all components of the extracellular matrix. Preclinical studies testing the efficacy of MMP suppression in tumor models were so compelling that synthetic metalloproteinase inhibitors (MPIs) were rapidly developed and routed into human clinical trials. The results of these trials have been disappointing. Here we review the studies that brought MPIs into clinical testing and discuss the design and outcome of the trials in light of new information about the cellular source, substrates, and mode of action of MMPs at different stages of tumor progression. The important lessons learned from the MPI experience may be of great value for future studies of MPIs and for cancer drug development in general.

1 Department of Pathology and Cancer Research Institute, University of California, 2340 Sutter Street, San Francisco, CA 94143, USA.
2 Department of Cancer Biology, Vanderbilt University, Nashville, TN 37232, USA.
*   To whom correspondence should be addressed. E-mail: lynn.matrisian{at}vanderbilt.edu

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Extracellular Matrix Molecules: Potential Targets in Pharmacotherapy.
H. Jarvelainen, A. Sainio, M. Koulu, T. N. Wight, and R. Penttinen (2009)
Pharmacol. Rev. 61, 198-223
   Abstract »    Full Text »    PDF »
Genetic Inactivation of ADAMTS15 Metalloprotease in Human Colorectal Cancer.
C. G. Viloria, A. J. Obaya, A. Moncada-Pazos, M. Llamazares, A. Astudillo, G. Capella, S. Cal, and C. Lopez-Otin (2009)
Cancer Res. 69, 4926-4934
   Abstract »    Full Text »    PDF »
Doxycycline causes regression of endometriotic implants: a rat model.
P. Akkaya, G. Onalan, N. Haberal, N. Bayraktar, B. Mulayim, and H. B. Zeyneloglu (2009)
Hum. Reprod.
   Abstract »    Full Text »    PDF »
Guanylyl Cyclase C Prevents Colon Cancer Metastasis by Regulating Tumor Epithelial Cell Matrix Metalloproteinase-9.
W. J. Lubbe, D. S. Zuzga, Z. Zhou, W. Fu, J. Pelta-Heller, R. J. Muschel, S. A. Waldman, and G. M. Pitari (2009)
Cancer Res. 69, 3529-3536
   Abstract »    Full Text »    PDF »
MMP13, Birc2 (cIAP1), and Birc3 (cIAP2), Amplified on Chromosome 9, Collaborate with p53 Deficiency in Mouse Osteosarcoma Progression.
O. Ma, W.-W. Cai, L. Zender, T. Dayaram, J. Shen, A. J. Herron, S. W. Lowe, T.-K. Man, C. C. Lau, and L. A. Donehower (2009)
Cancer Res. 69, 2559-2567
   Abstract »    Full Text »    PDF »
Distinct functions for the catalytic and hemopexin domains of a Drosophila matrix metalloproteinase.
B. M. Glasheen, A. T. Kabra, and A. Page-McCaw (2009)
PNAS 106, 2659-2664
   Abstract »    Full Text »    PDF »
Selective Inhibition of Matrix Metalloproteinase-14 Blocks Tumor Growth, Invasion, and Angiogenesis.
L. Devy, L. Huang, L. Naa, N. Yanamandra, H. Pieters, N. Frans, E. Chang, Q. Tao, M. Vanhove, A. Lejeune, et al. (2009)
Cancer Res. 69, 1517-1526
   Abstract »    Full Text »    PDF »
Differences in the Gene Expression Profile of Matrix Metalloproteinases (MMPs) and their Inhibitors (TIMPs) in Primary Colorectal Tumors and their Synchronous Liver Metastases.
B. GENTNER, A. WEIN, R. S. CRONER, I. ZEITTRAEGER, R. M. WIRTZ, F. ROEDEL, A. DIMMLER, L. DORLAQUE, W. HOHENBERGER, E. G. HAHN, et al. (2009)
Anticancer Res 29, 67-74
   Abstract »    Full Text »    PDF »
Heparan Sulfate Regulates ADAM12 through a Molecular Switch Mechanism.
H. P. Sorensen, R. R. Vives, C. Manetopoulos, R. Albrechtsen, M. C. Lydolph, J. Jacobsen, J. R. Couchman, and U. M. Wewer (2008)
J. Biol. Chem. 283, 31920-31932
   Abstract »    Full Text »    PDF »
Blockade of the RhoA-JNK-c-Jun-MMP2 Cascade by Atorvastatin Reduces Osteosarcoma Cell Invasion.
O. Fromigue, Z. Hamidouche, and P. J. Marie (2008)
J. Biol. Chem. 283, 30549-30556
   Abstract »    Full Text »    PDF »
Molecular Determinants of Matrix Metalloproteinase-12 Covalent Modification by a Photoaffinity Probe: INSIGHTS INTO ACTIVITY-BASED PROBE DEVELOPMENT AND CONFORMATIONAL VARIABILITY OF MATRIX METALLOPROTEINASES.
A.-S. Dabert-Gay, B. Czarny, L. Devel, F. Beau, E. Lajeunesse, S. Bregant, R. Thai, A. Yiotakis, and V. Dive (2008)
J. Biol. Chem. 283, 31058-31067
   Abstract »    Full Text »    PDF »
Molecular profile of endothelial invasion of three-dimensional collagen matrices: insights into angiogenic sprout induction in wound healing.
S.-C. Su, E. A. Mendoza, H.-i. Kwak, and K. J. Bayless (2008)
Am J Physiol Cell Physiol 295, C1215-C1229
   Abstract »    Full Text »    PDF »
Keratinocyte Expression of MMP3 Enhances Differentiation and Prevents Tumor Establishment.
L. J. McCawley, J. Wright, B. J. LaFleur, H. C. Crawford, and L. M. Matrisian (2008)
Am. J. Pathol. 173, 1528-1539
   Abstract »    Full Text »    PDF »
The AIB1 Oncogene Promotes Breast Cancer Metastasis by Activation of PEA3-Mediated Matrix Metalloproteinase 2 (MMP2) and MMP9 Expression.
L. Qin, L. Liao, A. Redmond, L. Young, Y. Yuan, H. Chen, B. W. O'Malley, and J. Xu (2008)
Mol. Cell. Biol. 28, 5937-5950
   Abstract »    Full Text »    PDF »
Metadegradomics: Toward in Vivo Quantitative Degradomics of Proteolytic Post-translational Modifications of the Cancer Proteome.
A. Doucet, G. S. Butler, D. Rodriguez, A. Prudova, and C. M. Overall (2008)
Mol. Cell. Proteomics 7, 1925-1951
   Abstract »    Full Text »    PDF »
p120 and Kaiso Regulate Helicobacter pylori-induced Expression of Matrix Metalloproteinase-7.
S. R. Ogden, L. E. Wroblewski, C. Weydig, J. Romero-Gallo, D. P. O'Brien, D. A. Israel, U. S. Krishna, B. Fingleton, A. B. Reynolds, S. Wessler, et al. (2008)
Mol. Biol. Cell 19, 4110-4121
   Abstract »    Full Text »    PDF »
Tube Travel: The Role of Proteases in Individual and Collective Cancer Cell Invasion.
P. Friedl and K. Wolf (2008)
Cancer Res. 68, 7247-7249
   Abstract »    Full Text »    PDF »
An Immortalization-Dependent Switch in Integrin Function Up-regulates MMP-9 to Enhance Tumor Cell Invasion.
J. M. Lamar, K. M. Pumiglia, and C. M. DiPersio (2008)
Cancer Res. 68, 7371-7379
   Abstract »    Full Text »    PDF »
Matrix Metalloproteinase 9 Facilitates West Nile Virus Entry into the Brain.
P. Wang, J. Dai, F. Bai, K.-F. Kong, S. J. Wong, R. R. Montgomery, J. A. Madri, and E. Fikrig (2008)
J. Virol. 82, 8978-8985
   Abstract »    Full Text »    PDF »
Targeted therapies for pancreatic cancer.
S. A. Danovi, H. H. Wong, and N. R. Lemoine (2008)
Br. Med. Bull. 87, 97-130
   Abstract »    Full Text »    PDF »
Targeting a metalloprotease-PAR1 signaling system with cell-penetrating pepducins inhibits angiogenesis, ascites, and progression of ovarian cancer.
A. Agarwal, L. Covic, L. M. Sevigny, N. C. Kaneider, K. Lazarides, G. Azabdaftari, S. Sharifi, and A. Kuliopulos (2008)
Mol. Cancer Ther. 7, 2746-2757
   Abstract »    Full Text »    PDF »
Matrix metalloproteinase expression and outcome in patients with breast cancer: analysis of a published database.
P. M. McGowan and M. J. Duffy (2008)
Ann. Onc. 19, 1566-1572
   Abstract »    Full Text »    PDF »
Effect of Ablation or Inhibition of Stromal Matrix Metalloproteinase-9 on Lung Metastasis in a Breast Cancer Model Is Dependent on Genetic Background.
M. D. Martin, K. J. Carter, S. R. Jean-Philippe, M. Chang, S. Mobashery, S. Thiolloy, C. C. Lynch, L. M. Matrisian, and B. Fingleton (2008)
Cancer Res. 68, 6251-6259
   Abstract »    Full Text »    PDF »
Tumor-Associated MICA Is Shed by ADAM Proteases.
I. Waldhauer, D. Goehlsdorf, F. Gieseke, T. Weinschenk, M. Wittenbrink, A. Ludwig, S. Stevanovic, H.-G. Rammensee, and A. Steinle (2008)
Cancer Res. 68, 6368-6376
   Abstract »    Full Text »    PDF »
Pharmacoproteomics of a Metalloproteinase Hydroxamate Inhibitor in Breast Cancer Cells: Dynamics of Membrane Type 1 Matrix Metalloproteinase-Mediated Membrane Protein Shedding.
G. S. Butler, R. A. Dean, E. M. Tam, and C. M. Overall (2008)
Mol. Cell. Biol. 28, 4896-4914
   Abstract »    Full Text »    PDF »
Tissue Inhibitors of Metalloproteinases in Cell Signaling: Metalloproteinase-Independent Biological Activities.
W. G. Stetler-Stevenson (2008)
Science Signaling 1, re6
   Abstract »    Full Text »    PDF »
Potentiation of NK cell-mediated cytotoxicity in human lung adenocarcinoma: role of NKG2D-dependent pathway.
B. Le Maux Chansac, D. Misse, C. Richon, I. Vergnon, M. Kubin, J.-C. Soria, A. Moretta, S. Chouaib, and F. Mami-Chouaib (2008)
Int. Immunol. 20, 801-810
   Abstract »    Full Text »    PDF »
Review: Tissue remodeling and angiogenesis in asthma: the role of the eosinophil.
A.H. Nissim Ben Efraim and F. Levi-Schaffer (2008)
Therapeutic Advances in Respiratory Disease 2, 163-171
   Abstract »    PDF »
Frzb, a Secreted Wnt Antagonist, Decreases Growth and Invasiveness of Fibrosarcoma Cells Associated with Inhibition of Met Signaling.
Y. Guo, J. Xie, E. Rubin, Y.-X. Tang, F. Lin, X. Zi, and B. H. Hoang (2008)
Cancer Res. 68, 3350-3360
   Abstract »    Full Text »    PDF »
Gene Transfer of Matrix Metalloproteinase-9 Induces Tumor Regression of Breast Cancer In vivo.
C. Bendrik, J. Robertson, J. Gauldie, and C. Dabrosin (2008)
Cancer Res. 68, 3405-3412
   Abstract »    Full Text »    PDF »
A Suppressive Role of Mitogen Inducible Gene-2 in Mesenchymal Cancer Cell Invasion.
X. Shi and C. Wu (2008)
Mol. Cancer Res. 6, 715-724
   Abstract »    Full Text »    PDF »
Statin-Induced Inhibition of 3-Hydroxy-3-Methyl Glutaryl Coenzyme A Reductase Sensitizes Human Osteosarcoma Cells to Anticancer Drugs.
O. Fromigue, Z. Hamidouche, and P. J. Marie (2008)
J. Pharmacol. Exp. Ther. 325, 595-600
   Abstract »    Full Text »    PDF »
Genetic polymorphisms of matrix metalloproteinase 12 and 13 genes are implicated in endometriosis progression.
B. Borghese, J.-D. Chiche, D. Vernerey, C. Chenot, O. Mir, G. Bijaoui, C. Bonaiti-Pellie, and C. Chapron (2008)
Hum. Reprod. 23, 1207-1213
   Abstract »    Full Text »    PDF »
Endothelial sprouting and angiogenesis: matrix metalloproteinases in the lead.
V. W.M. van Hinsbergh and P. Koolwijk (2008)
Cardiovasc Res 78, 203-212
   Abstract »    Full Text »    PDF »
Matrix Metalloproteinase-induced Fibrosis and Malignancy in Breast and Lung.
D. C. Radisky and J. A. Przybylo (2008)
Proceedings of the ATS 5, 316-322
   Abstract »    Full Text »    PDF »
Matrix Metalloproteinase-8 Functions as a Metastasis Suppressor through Modulation of Tumor Cell Adhesion and Invasion.
A. Gutierrez-Fernandez, A. Fueyo, A. R. Folgueras, C. Garabaya, C. J. Pennington, S. Pilgrim, D. R. Edwards, D. L. Holliday, J. L. Jones, P. N. Span, et al. (2008)
Cancer Res. 68, 2755-2763
   Abstract »    Full Text »    PDF »
Membrane Type 1 Matrix Metalloproteinase Induces Epithelial-to-Mesenchymal Transition in Prostate Cancer.
J. Cao, C. Chiarelli, O. Richman, K. Zarrabi, P. Kozarekar, and S. Zucker (2008)
J. Biol. Chem. 283, 6232-6240
   Abstract »    Full Text »    PDF »
Distinct Functionality of Tumor Cell-Derived Gelatinases during Formation of Liver Metastases.
M. Gerg, C. Kopitz, S. Schaten, A. Tschukes, C. Kahlert, M. Stangl, C. W. Hann von Weyhern, B. L.D.M. Brucher, D. R. Edwards, K. Brand, et al. (2008)
Mol. Cancer Res. 6, 341-351
   Abstract »    Full Text »    PDF »
A Novel High-Throughput Screening System Identifies a Small Molecule Repressive for Matrix Metalloproteinase-9 Expression.
R. R. Nair, H. Avila, X. Ma, Z. Wang, M. Lennartz, B. G. Darnay, D. D. Boyd, and C. Yan (2008)
Mol. Pharmacol. 73, 919-929
   Abstract »    Full Text »    PDF »
Blockade of Tumor Growth Due to Matrix Metalloproteinase-9 Inhibition Is Mediated by Sequential Activation of 1-Integrin, ERK, and NF-{kappa}B.
P. Bhoopathi, C. Chetty, S. Kunigal, S. K. Vanamala, J. S. Rao, and S. S. Lakka (2008)
J. Biol. Chem. 283, 1545-1552
   Abstract »    Full Text »    PDF »
Matrix metalloproteinase-2 regulates vascular patterning and growth affecting tumor cell survival and invasion in GBM.
R. Du, C. Petritsch, K. Lu, P. Liu, A. Haller, R. Ganss, H. Song, S. Vandenberg, and G. Bergers (2008)
Neuro-oncol 10, 254-264
   Abstract »    Full Text »    PDF »
Galectin-3 Cleavage: A Novel Surrogate Marker for Matrix Metalloproteinase Activity in Growing Breast Cancers.
P. Nangia-Makker, T. Raz, L. Tait, V. Hogan, R. Fridman, and A. Raz (2007)
Cancer Res. 67, 11760-11768
   Abstract »    Full Text »    PDF »
Src Continues Aging: Current and Future Clinical Directions.
S. Kopetz, A. N. Shah, and G. E. Gallick (2007)
Clin. Cancer Res. 13, 7232-7236
   Abstract »    Full Text »    PDF »
Inhibitory effects of resistin-13-peptide on the proliferation, adhesion, and invasion of MDA-MB-231 in human breast carcinoma cells.
B. Pan, M.-H. Zhao, Z. Chen, L. Lu, Y. Wang, D.-W. Shi, and P.-Z. Han (2007)
Endocr. Relat. Cancer 14, 1063-1071
   Abstract »    Full Text »    PDF »
Amino-Biphosphonate Mediated MMP-9 Inhibition Breaks the Tumor-Bone Marrow Axis Responsible for Myeloid-Derived Suppressor Cell Expansion and Macrophage Infiltration in Tumor Stroma.
C. Melani, S. Sangaletti, F. M. Barazzetta, Z. Werb, and M. P. Colombo (2007)
Cancer Res. 67, 11438-11446
   Abstract »    Full Text »    PDF »
Targeting Vacuolar H+-ATPases as a New Strategy against Cancer.
S. Fais, A. De Milito, H. You, and W. Qin (2007)
Cancer Res. 67, 10627-10630
   Abstract »    Full Text »    PDF »
Keeping Out the Bad Guys: Gateway to Cellular Target Therapy.
T. Kitamura and M. M. Taketo (2007)
Cancer Res. 67, 10099-10102
   Abstract »    Full Text »    PDF »
ECRG2 inhibits cancer cell migration, invasion and metastasis through the down-regulation of uPA/plasmin activity.
G. Huang, Z. Hu, M. Li, Y. Cui, Y. Li, L. Guo, W. Jiang, and S. H. Lu (2007)
Carcinogenesis 28, 2274-2281
   Abstract »    Full Text »    PDF »
Synergistic Up-Regulation of Epithelial Cell Matrix Metalloproteinase-9 Secretion in Tuberculosis.
P. T. Elkington, J. A. Green, J. E. Emerson, L. D. Lopez-Pascua, J. J. Boyle, C. M. O'Kane, and J. S. Friedland (2007)
Am. J. Respir. Cell Mol. Biol. 37, 431-437
   Abstract »    Full Text »    PDF »
Complementary Roles of Intracellular and Pericellular Collagen Degradation Pathways In Vivo.
R. A. Wagenaar-Miller, L. H. Engelholm, J. Gavard, S. S. Yamada, J. S. Gutkind, N. Behrendt, T. H. Bugge, and K. Holmbeck (2007)
Mol. Cell. Biol. 27, 6309-6322
   Abstract »    Full Text »    PDF »
Engineered Sarafotoxins as Tissue Inhibitor of Metalloproteinases-like Matrix Metalloproteinase Inhibitors.
J. L. Lauer-Fields, M. Cudic, S. Wei, F. Mari, G. B. Fields, and K. Brew (2007)
J. Biol. Chem. 282, 26948-26955
   Abstract »    Full Text »    PDF »
Proteolytic Degradation of VE-Cadherin Alters the Blood-Retinal Barrier in Diabetes.
D. Navaratna, P. G. McGuire, G. Menicucci, and A. Das (2007)
Diabetes 56, 2380-2387
   Abstract »    Full Text »    PDF »
Prognosis-Determinant Candidate Genes Identified by Whole Genome Scanning in Eyes with Pterygia.
C.-H. Kuo, D. Miyazaki, N. Nawata, T. Tominaga, A. Yamasaki, Y. Sasaki, and Y. Inoue (2007)
Invest. Ophthalmol. Vis. Sci. 48, 3566-3575
   Abstract »    Full Text »    PDF »
FSH stimulates the expression of the ADAMTS-16 protease in mature human ovarian follicles.
S. Gao, C. De Geyter, K. Kossowska, and H. Zhang (2007)
Mol. Hum. Reprod. 13, 465-471
   Abstract »    Full Text »    PDF »
Cortactin Is an Essential Regulator of Matrix Metalloproteinase Secretion and Extracellular Matrix Degradation in Invadopodia.
E. S. Clark, A. S. Whigham, W. G. Yarbrough, and A. M. Weaver (2007)
Cancer Res. 67, 4227-4235
   Abstract »    Full Text »    PDF »
Stroma-Derived Matrix Metalloproteinase (MMP)-2 Promotes Membrane Type 1-MMP-Dependent Tumor Growth in Mice.
K. Taniwaki, H. Fukamachi, K. Komori, Y. Ohtake, T. Nonaka, T. Sakamoto, T. Shiomi, Y. Okada, T. Itoh, S. Itohara, et al. (2007)
Cancer Res. 67, 4311-4319
   Abstract »    Full Text »    PDF »
Hu/Mu ProtIn Oligonucleotide Microarray: Dual-Species Array for Profiling Protease and Protease Inhibitor Gene Expression in Tumors and Their Microenvironment.
D. R. Schwartz, K. Moin, B. Yao, L. M. Matrisian, L. M. Coussens, T. H. Bugge, B. Fingleton, H. B. Acuff, M. Sinnamon, H. Nassar, et al. (2007)
Mol. Cancer Res. 5, 443-454
   Abstract »    Full Text »    PDF »
Increased Expression of the Collagen Internalization Receptor uPARAP/Endo180 in the Stroma of Head and Neck Cancer.
J. Sulek, R. A. Wagenaar-Miller, J. Shireman, A. Molinolo, D. H. Madsen, L. H. Engelholm, N. Behrendt, and T. H. Bugge (2007)
J. Histochem. Cytochem. 55, 347-353
   Abstract »    Full Text »    PDF »
Proteomics Discovery of Metalloproteinase Substrates in the Cellular Context by iTRAQTM Labeling Reveals a Diverse MMP-2 Substrate Degradome.
R. A. Dean and C. M. Overall (2007)
Mol. Cell. Proteomics 6, 611-623
   Abstract »    Full Text »    PDF »
A Phase I Pharmacokinetic and Pharmacodynamic Study of S-3304, a Novel Matrix Metalloproteinase Inhibitor, in Patients with Advanced and Refractory Solid Tumors.
A. A. Chiappori, S. G. Eckhardt, R. Bukowski, D. M. Sullivan, M. Ikeda, Y. Yano, T. Yamada-Sawada, Y. Kambayashi, K. Tanaka, M. M. Javle, et al. (2007)
Clin. Cancer Res. 13, 2091-2099
   Abstract »    Full Text »    PDF »
Selective Inhibition of ADAM Metalloproteases as a Novel Approach for Modulating ErbB Pathways in Cancer.
J. S. Fridman, E. Caulder, M. Hansbury, X. Liu, G. Yang, Q. Wang, Y. Lo, B.-B. Zhou, M. Pan, S. M. Thomas, et al. (2007)
Clin. Cancer Res. 13, 1892-1902
   Abstract »    Full Text »    PDF »
Activity-based probes for proteomic profiling of histone deacetylase complexes.
C. M. Salisbury and B. F. Cravatt (2007)
PNAS 104, 1171-1176
   Abstract »    Full Text »    PDF »
Differentiated thyroid cancer cell invasion is regulated through epidermal growth factor receptor-dependent activation of matrix metalloproteinase (MMP)-2/gelatinase A.
M. W Yeh, J.-P. Rougier, J.-W. Park, Q.-Y. Duh, M. Wong, Z. Werb, and O. H Clark (2006)
Endocr. Relat. Cancer 13, 1173-1183
   Abstract »    Full Text »    PDF »
Use of an Aggressive MCF-7 Cell Line Variant, TMX2-28, to Study Cell Invasion in Breast Cancer.
J. M. Gozgit, B. T. Pentecost, S. A. Marconi, C. N. Otis, C. Wu, and K. F. Arcaro (2006)
Mol. Cancer Res. 4, 905-913
   Abstract »    Full Text »    PDF »
Monocyte/macrophage infiltration in tumors: modulators of angiogenesis.
A. E. M. Dirkx, M. G. A. oude Egbrink, J. Wagstaff, and A. W. Griffioen (2006)
J. Leukoc. Biol. 80, 1183-1196
   Abstract »    Full Text »    PDF »
A cancer cell metalloprotease triad regulates the basement membrane transmigration program.
K. Hotary, X.-Y. Li, E. Allen, S. L. Stevens, and S. J. Weiss (2006)
Genes & Dev. 20, 2673-2686
   Abstract »    Full Text »    PDF »
Chronic Matrix Metalloproteinase Inhibition Following Myocardial Infarction in Mice: Differential Effects on Short and Long-Term Survival.
F. G. Spinale, G. P. Escobar, J. W. Hendrick, L. L. Clark, S. S. Camens, J. P. Mingoia, C. G. Squires, R. E. Stroud, and J. S. Ikonomidis (2006)
J. Pharmacol. Exp. Ther. 318, 966-973
   Abstract »    Full Text »    PDF »
TGF-{beta} and metalloproteinases differentially suppress NKG2D ligand surface expression on malignant glioma cells.
G. Eisele, J. Wischhusen, M. Mittelbronn, R. Meyermann, I. Waldhauer, A. Steinle, M. Weller, and M. A. Friese (2006)
Brain 129, 2416-2425
   Abstract »    Full Text »    PDF »
Cell-surface association between matrix metalloproteinases and integrins: role of the complexes in leukocyte migration and cancer progression.
M. Stefanidakis and E. Koivunen (2006)
Blood 108, 1441-1450
   Abstract »    Full Text »    PDF »
Oncolytic efficacy and enhanced safety of measles virus activated by tumor-secreted matrix metalloproteinases..
C. Springfeld, V. von Messling, M. Frenzke, G. Ungerechts, C. J. Buchholz, and R. Cattaneo (2006)
Cancer Res. 66, 7694-7700
   Abstract »    Full Text »    PDF »
Tumor-derived matrix metalloproteinase-1 targets endothelial proteinase-activated receptor 1 promoting endothelial cell activation..
T. Goerge, A. Barg, E.-M. Schnaeker, B. Poppelmann, V. Shpacovitch, A. Rattenholl, C. Maaser, T. A. Luger, M. Steinhoff, and S. W. Schneider (2006)
Cancer Res. 66, 7766-7774
   Abstract »    Full Text »    PDF »
Interaction of HIV Tat and matrix metalloproteinase in HIV neuropathogenesis: a new host defense mechanism.
J. Rumbaugh, J. Turchan-Cholewo, D. Galey, C. St. Hillaire, C. Anderson, K. Conant, and A. Nath (2006)
FASEB J 20, 1736-1738
   Abstract »    Full Text »    PDF »
An MMP liberates the Ninjurin A ectodomain to signal a lossof cell adhesion.
S. Zhang, G. M. Dailey, E. Kwan, B. M. Glasheen, G. E. Sroga, and A. Page-McCaw (2006)
Genes & Dev. 20, 1899-1910
   Abstract »    Full Text »    PDF »
Proteomic Identification of Desmoglein 2 and Activated Leukocyte Cell Adhesion Molecule as Substrates of ADAM17 and ADAM10 by Difference Gel Electrophoresis..
J. J. Bech-Serra, B. Santiago-Josefat, C. Esselens, P. Saftig, J. Baselga, J. Arribas, and F. Canals (2006)
Mol. Cell. Biol. 26, 5086-5095
   Abstract »    Full Text »    PDF »
Conditional Activation of RET/PTC3 and BRAFV600E in Thyroid Cells Is Associated with Gene Expression Profiles that Predict a Preferential Role of BRAF in Extracellular Matrix Remodeling..
C. Mesa Jr., M. Mirza, N. Mitsutake, M. Sartor, M. Medvedovic, C. Tomlinson, J. A Knauf, G. F. Weber, and J. A. Fagin (2006)
Cancer Res. 66, 6521-6529
   Abstract »    Full Text »    PDF »
Macrophage elastase (matrix metalloproteinase-12) suppresses growth of lung metastases..
A. M. Houghton, J. L. Grisolano, M. L. Baumann, D. K. Kobayashi, R. D. Hautamaki, L. C. Nehring, L. A. Cornelius, and S. D. Shapiro (2006)
Cancer Res. 66, 6149-6155
   Abstract »    Full Text »    PDF »
Conflicting results from clinical observations and murine models: what is the role of plasminogen activators in tumor growth?.
M. Narazaki and G. Tosato (2006)
J Natl Cancer Inst 98, 726-727
   Full Text »    PDF »
Protease specificity determination by using cellular libraries of peptide substrates (CLiPS).
K. T. Boulware and P. S. Daugherty (2006)
PNAS 103, 7583-7588
   Abstract »    Full Text »    PDF »
Development of Selective Inhibitors and Substrate of Matrix Metalloproteinase-12.
L. Devel, V. Rogakos, A. David, A. Makaritis, F. Beau, P. Cuniasse, A. Yiotakis, and V. Dive (2006)
J. Biol. Chem. 281, 11152-11160
   Abstract »    Full Text »    PDF »
Pericellular Proteases in Angiogenesis and Vasculogenesis.
V. W.M. van Hinsbergh, M. A. Engelse, and P. H.A. Quax (2006)
Arterioscler. Thromb. Vasc. Biol. 26, 716-728
   Abstract »    Full Text »    PDF »
Tumor epithelial cell matrix metalloproteinase 9 is a target for antimetastatic therapy in colorectal cancer..
W. J. Lubbe, Z. Y. Zhou, W. Fu, D. Zuzga, S. Schulz, R. Fridman, R. J. Muschel, S. A. Waldman, and G. M. Pitari (2006)
Clin. Cancer Res. 12, 1876-1882
   Abstract »    Full Text »    PDF »
Inhibitory Effects of Lycopene on the Adhesion, Invasion, and Migration of SK-Hep1 Human Hepatoma Cells..
E.-S. Hwang and H. J. Lee (2006)
Experimental Biology and Medicine 231, 322-327
   Abstract »    Full Text »    PDF »
Matrix metalloproteinases in destructive pulmonary pathology.
P T G Elkington and J S Friedland (2006)
Thorax 61, 259-266
   Abstract »    Full Text »    PDF »
Relevance of matrix metalloproteinases and their inhibitors after myocardial infarction: A temporal and spatial window.
D. Vanhoutte, M. Schellings, Y. Pinto, and S. Heymans (2006)
Cardiovasc Res 69, 604-613
   Abstract »    Full Text »    PDF »
Atherosclerosis and proteinase activation.
C. M. Dollery and P. Libby (2006)
Cardiovasc Res 69, 625-635
   Abstract »    Full Text »    PDF »
Pancreatic Cancer in Mice and Man: The Penn Workshop 2004.
R. H. Hruban, A. K. Rustgi, T. A. Brentnall, M. A. Tempero, C. V. Wright, and D. A. Tuveson (2006)
Cancer Res. 66, 14-17
   Abstract »    Full Text »    PDF »
Matrix Metalloproteinase-9 from Bone Marrow-Derived Cells Contributes to Survival but not Growth of Tumor Cells in the Lung Microenvironment.
H. B. Acuff, K. J. Carter, B. Fingleton, D. L. Gorden, and L. M. Matrisian (2006)
Cancer Res. 66, 259-266
   Abstract »    Full Text »    PDF »
Involvement of Matrix Metalloproteinase Activity in Hormone-Induced Mammary Tumor Regression.
M. Simian, A. Molinolo, and C. Lanari (2006)
Am. J. Pathol. 168, 270-279
   Abstract »    Full Text »    PDF »
Matrix metalloproteinase-9 gene deletion facilitates angiogenesis after myocardial infarction.
M. L. Lindsey, G. P. Escobar, L. W. Dobrucki, D. K. Goshorn, S. Bouges, J. T. Mingoia, D. M. McClister Jr., H. Su, J. Gannon, C. MacGillivray, et al. (2006)
Am J Physiol Heart Circ Physiol 290, H232-H239
   Abstract »    Full Text »    PDF »
Blockade of the TGF-{beta} Superfamily by Smad7: Breaking a Link in the Metastatic Chain.
I. J. Fidler (2005)
J Natl Cancer Inst 97, 1714-1715
   Full Text »    PDF »
Tumour matrilysin expression predicts metastatic potential of stage I (pT1) colon and rectal cancers.
S Kurokawa, Y Arimura, H Yamamoto, Y Adachi, T Endo, T Sato, T Suga, M Hosokawa, Y Shinomura, and K Imai (2005)
Gut 54, 1751-1758
   Abstract »    Full Text »    PDF »
Unexpected Effect of Matrix Metalloproteinase Down-Regulation on Vascular Intravasation and Metastasis of Human Fibrosarcoma Cells Selected In vivo for High Rates of Dissemination.
E. I. Deryugina, A. Zijlstra, J. J. Partridge, T. A. Kupriyanova, M. A. Madsen, T. Papagiannakopoulos, and J. P. Quigley (2005)
Cancer Res. 65, 10959-10969
   Abstract »    Full Text »    PDF »
Tumor Immunotherapy Targeting Fibroblast Activation Protein, a Product Expressed in Tumor-Associated Fibroblasts.
J. Lee, M. Fassnacht, S. Nair, D. Boczkowski, and E. Gilboa (2005)
Cancer Res. 65, 11156-11163
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)