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Science 22 March 2002:
Vol. 295. no. 5563, pp. 2247 - 2249
DOI: 10.1126/science.1069280
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Reports

Liquid-State NMR and Scalar Couplings in Microtesla Magnetic Fields

Robert McDermott,13* Andreas H. Trabesinger,23 Michael Mück,4 Erwin L. Hahn,1 Alexander Pines,23 John Clarke13

We obtained nuclear magnetic resonance (NMR) spectra of liquids in fields of a few microtesla, using prepolarization in fields of a few millitesla and detection with a dc superconducting quantum interference device (SQUID). Because the sensitivity of the SQUID is frequency independent, we enhanced both signal-to-noise ratio and spectral resolution by detecting the NMR signal in extremely low magnetic fields, where the NMR lines become very narrow even for grossly inhomogeneous measurement fields. In the absence of chemical shifts, proton-phosphorous scalar (J) couplings have been detected, indicating the presence of specific covalent bonds. This observation opens the possibility for "pure J spectroscopy" as a diagnostic tool for the detection of molecules in low magnetic fields.

1 Department of Physics and
2 Department of Chemistry, University of California, Berkeley, CA 94720, USA.
3 Materials Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.
4 Institute of Applied Physics, University of Giessen, Giessen D-35392 Germany.
*   To whom correspondence should be addressed. E-mail: rmcderm{at}socrates.berkeley.edu

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