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Science 8 March 2002:
Vol. 295. no. 5561, pp. 1901 - 1904
DOI: 10.1126/science.1068356
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Reports

Coordination of PIC Assembly and Chromatin Remodeling During Differentiation-Induced Gene Activation

Evi Soutoglou, Iannis Talianidis*

We analyzed the ordered recruitment of factors to the human alpha 1 antitrypsin promoter around the initial activation of the gene during enterocyte differentiation. We found that a complete preinitiation complex, including phosphorylated RNA pol II, was assembled at the promoter long before transcriptional activation. The histone acetyltransferases CBP and P/CAF were recruited subsequently, but local histone hyperacetylation was delayed. After transient recruitment of the human Brahma homolog hBrm, remodeling of the neighboring nucleosome coincided with transcription initiation. The results suggest that, at this promoter, chromatin reconfiguration is a defining step of the initiation process, acting after the assembly of the Pol II machinery.

Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology Hellas, Post Office Box 1527, 711 10 Herakleion, Crete, Greece.
*   To whom correspondence should be addressed. E-mail: talianid{at}imbb.forth.gr

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