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Science 1 March 2002:
Vol. 295. no. 5560, pp. 1726 - 1729
DOI: 10.1126/science.1069094
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Reports

Colorectal Cancer in Mice Genetically Deficient in the Mucin Muc2

Anna Velcich,1* WanCai Yang,1 Joerg Heyer,2 Alessandra Fragale,1 Courtney Nicholas,1 Stephanie Viani,1 Raju Kucherlapati,3 Martin Lipkin,4 Kan Yang,4 Leonard Augenlicht1

The gastrointestinal tract is lined by a layer of mucus comprised of highly glycosylated proteins called mucins. To evaluate the importance of mucin in intestinal carcinogenesis, we constructed mice genetically deficient in Muc2, the most abundant secreted gastrointestinal mucin. Muc2-/- mice displayed aberrant intestinal crypt morphology and altered cell maturation and migration. Most notably, the mice frequently developed adenomas in the small intestine that progressed to invasive adenocarcinoma, as well as rectal tumors. Thus, Muc2 is involved in the suppression of colorectal cancer.

1 Department of Oncology, Albert Einstein Cancer Center/Montefiore Medical Center, 111 East 210 Street, Bronx, NY 10467, USA.
2 Memory Pharmaceuticals Corporation 100, Philips Parkway, Montvale, NJ 07645, USA.
3 Harvard Medical School, Brigham & Women's Hospital, 20 Shattuck Street, Boston, MA 02115, USA.
4 Strang Cancer Prevention Center, 1300 York Avenue, New York, NY 10021, USA.
*   To whom correspondence should be addressed. E-mail: velcich{at}aecom.yu.edu

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