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Science 8 February 2002:
Vol. 295. no. 5557, pp. 1005 - 1009
DOI: 10.1126/science.1068660
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A Bioartificial Liver--State of the Art

Alastair J. Strain,* James M. Neuberger

End-stage liver disease is treated by liver transplantation, but donor organ shortages remain a serious problem. This has prompted the design of bioartificial liver devices to "bridge" patients until they either recover or receive a liver transplant. In these devices, patient plasma is circulated extracorporeally through a bioreactor that houses liver cells (hepatocytes) sandwiched between artificial plates or capillaries.

Schools of Biosciences and Medicine, University of Birmingham, and Liver and Hepatobiliary Unit, University Hospital Birmingham, Edgbaston, Birmingham B15 2TH, UK.
*   To whom correspondence should be addressed. E-mail: a.j.strain{at}bham.ac.uk

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