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Science 25 January 2002:
Vol. 295. no. 5555, pp. 690 - 694
DOI: 10.1126/science.1066168
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Reports

Dynamic Brain Sources of Visual Evoked Responses

S. Makeig,13* M. Westerfield,134 T.-P. Jung,13 S. Enghoff,1 J. Townsend,4 E. Courchesne,4 T. J. Sejnowski12345

It has been long debated whether averaged electrical responses recorded from the scalp result from stimulus-evoked brain events or stimulus-induced changes in ongoing brain dynamics. In a human visual selective attention task, we show that nontarget event-related potentials were mainly generated by partial stimulus-induced phase resetting of multiple electroencephalographic processes. Independent component analysis applied to the single-trial data identified at least eight classes of contributing components, including those producing central and lateral posterior alpha, left and right mu, and frontal midline theta rhythms. Scalp topographies of these components were consistent with their generation in compact cortical domains.

1 Computational Neurobiology Laboratory and
2 The Howard Hughes Medical Institute, The Salk Institute, 10010 North Torrey Pines Road, San Diego, CA 92037, USA.
3 Institute for Neural Computation;
4 Department of Neurosciences, School of Medicine; and
5 Department of Biology, University of California, San Diego, CA 92093, USA.
*   To whom correspondence should be addressed. E-mail: smakeig{at}ucsd.edu

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