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Science 18 January 2002:
Vol. 295. no. 5554, pp. 457 - 462
DOI: 10.1126/science.1063654
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Review

Organogenesis--Heart and Blood Formation from the Zebrafish Point of View

Christine Thisse,1 Leonard I. Zon23

Organs are specialized tissues used for enhanced physiology and environmental adaptation. The cells of the embryo are genetically programmed to establish organ form and function through conserved developmental modules. The zebrafish is a powerful model system that is poised to contribute to our basic understanding of vertebrate organogenesis. This review develops the theme of modules and illustrates how zebrafish have been particularly useful for understanding heart and blood formation.

1 Institut de Biologie Moléculaire et Cellulaire, CNRS, INSERM, Université Louis Pasteur, 1 rue Laurent Fries, BP 163, 67404 Illkirch Cedex, C. U. de Strasbourg, France.
2 Division of Hematology/Oncology, Children's Hospital, Department of Medicine, Boston, MA 02115, USA.
3 Howard Hughes Medical Institute, Children's Hospital, Boston, MA 02115, USA.

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