Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 4 January 2002:
Vol. 295. no. 5552, pp. 143 - 147
DOI: 10.1126/science.1064285
Prev | Table of Contents | Next

Reports

Mediation of Hippocampal Mossy Fiber Long-Term Potentiation by Presynaptic Ih Channels

Jack Mellor, Roger A. Nicoll,* Dietmar Schmitz

Hippocampal mossy fiber long-term potentiation (LTP) is expressed presynaptically, but the exact mechanisms remain unknown. Here, we demonstrate the involvement of the hyperpolarization-activated cation channel (Ih) in the expression of mossy fiber LTP. Established LTP was blocked and reversed by Ih channel antagonists. Whole-cell recording from granule cells revealed that repetitive stimulation causes a calcium- and Ih-dependent long-lasting depolarization mediated by protein kinase A. Depolarization at the terminals would be expected to enhance transmitter release, whereas somatic depolarization would enhance the responsiveness of granule cells to afferent input. Thus, Ih channels play an important role in the long-lasting control of transmitter release and neuronal excitability.

Departments of Cellular and Molecular Pharmacology and Physiology, University of California, San Francisco, CA 94143, USA.
*   To whom correspondence should be addressed. E-mail: nicoll{at}phy.ucsf.edu

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Hyperpolarization-Activated Cation Channels: From Genes to Function.
M. Biel, C. Wahl-Schott, S. Michalakis, and X. Zong (2009)
Physiol Rev 89, 847-885
   Abstract »    Full Text »    PDF »
Activity-dependent depression of the spike after-depolarization generates long-lasting intrinsic plasticity in hippocampal CA3 pyramidal neurons.
J. T. Brown and A. D. Randall (2009)
J. Physiol. 587, 1265-1281
   Abstract »    Full Text »    PDF »
Intrinsic Conductances Actively Shape Excitatory and Inhibitory Postsynaptic Responses in Olfactory Bulb External Tufted Cells.
S. Liu and M. T. Shipley (2008)
J. Neurosci. 28, 10311-10322
   Abstract »    Full Text »    PDF »
Altered Dendritic Integration in Hippocampal Granule Cells of Spatial Learning-Impaired Aged Rats.
M. Krause, Z. Yang, G. Rao, F. P. Houston, and C. A. Barnes (2008)
J Neurophysiol 99, 2769-2778
   Abstract »    Full Text »    PDF »
Action Potential-Independent and Nicotinic Receptor-Mediated Concerted Release of Multiple Quanta at Hippocampal CA3-Mossy Fiber Synapses.
G. Sharma, M. Grybko, and S. Vijayaraghavan (2008)
J. Neurosci. 28, 2563-2575
   Abstract »    Full Text »    PDF »
Withdrawal From Intermittent Ethanol Exposure Increases Probability of Burst Firing in VTA Neurons In Vitro.
F. W. Hopf, M. Martin, B. T. Chen, M. S. Bowers, M. M. Mohamedi, and A. Bonci (2007)
J Neurophysiol 98, 2297-2310
   Abstract »    Full Text »    PDF »
Hyperpolarization-activated cation channels in fast-spiking interneurons of rat hippocampus.
Y. Aponte, C.-C. Lien, E. Reisinger, and P. Jonas (2006)
J. Physiol. 574, 229-243
   Abstract »    Full Text »    PDF »
Dynamic synapses as archives of synaptic history: state-dependent redistribution of synaptic efficacy in the rat hippocampal CA1.
T. Yasui, S. Fujisawa, M. Tsukamoto, N. Matsuki, and Y. Ikegaya (2005)
J. Physiol. 566, 143-160
   Abstract »    Full Text »    PDF »
{beta}-Adrenoceptor-mediated long-term up-regulation of the release machinery at rat cerebellar GABAergic synapses.
F. Saitow, H. Suzuki, and S. Konishi (2005)
J. Physiol. 565, 487-502
   Abstract »    Full Text »    PDF »
cAMP-Mediated Mechanisms for Pain Sensitization during Opioid Withdrawal.
B. Bie, Y. Peng, Y. Zhang, and Z. Z. Pan (2005)
J. Neurosci. 25, 3824-3832
   Abstract »    Full Text »    PDF »
Subthreshold inactivation of voltage-gated K+ channels modulates action potentials in neocortical bitufted interneurones from rats.
A. Korngreen, K. M. M. Kaiser, and Y. Zilberter (2005)
J. Physiol. 562, 421-437
   Abstract »    Full Text »    PDF »
Optical Quantal Analysis Indicates That Long-Term Potentiation at Single Hippocampal Mossy Fiber Synapses Is Expressed through Increased Release Probability, Recruitment of New Release Sites, and Activation of Silent Synapses.
C. A. Reid, D. B. Dixon, M. Takahashi, T. V. P. Bliss, and A. Fine (2004)
J. Neurosci. 24, 3618-3626
   Abstract »    Full Text »    PDF »
Homeostatic scaling of neuronal excitability by synaptic modulation of somatic hyperpolarization-activated Ih channels.
I. van Welie, J. A. van Hooft, and W. J. Wadman (2004)
PNAS 101, 5123-5128
   Abstract »    Full Text »    PDF »
Presynaptic homeostasis at CNS nerve terminals compensates for lack of a key Ca2+ entry pathway.
E. S. Piedras-Renteria, J. L. Pyle, M. Diehn, L. L. Glickfeld, N. C. Harata, Y. Cao, E. T. Kavalali, P. O. Brown, and R. W. Tsien (2004)
PNAS 101, 3609-3614
   Abstract »    Full Text »    PDF »
Calcium influx through hyperpolarization-activated cation channels (Ih channels) contributes to activity-evoked neuronal secretion.
X. Yu, K.-L. Duan, C.-F. Shang, H.-G. Yu, and Z. Zhou (2004)
PNAS 101, 1051-1056
   Abstract »    Full Text »    PDF »
International Union of Pharmacology. XLII. Compendium of Voltage-Gated Ion Channels: Cyclic Nucleotide-Modulated Channels.
F. Hofmann, M. Biel, and U. B. Kaupp (2003)
Pharmacol. Rev. 55, 587-589
   Abstract »    Full Text »    PDF »
Long-Term Plasticity of Intrinsic Excitability: Learning Rules and Mechanisms.
G. Daoudal and D. Debanne (2003)
Learn. Mem. 10, 456-465
   Abstract »    Full Text »    PDF »
Role of Subunit Heteromerization and N-Linked Glycosylation in the Formation of Functional Hyperpolarization-activated Cyclic Nucleotide-gated Channels.
B. Much, C. Wahl-Schott, X. Zong, A. Schneider, L. Baumann, S. Moosmang, A. Ludwig, and M. Biel (2003)
J. Biol. Chem. 278, 43781-43786
   Abstract »    Full Text »    PDF »
Type 8 Adenylyl Cyclase Is Targeted to Excitatory Synapses and Required for Mossy Fiber Long-Term Potentiation.
H. Wang, V. V. Pineda, G. C. K. Chan, S. T. Wong, L. J. Muglia, and D. R. Storm (2003)
J. Neurosci. 23, 9710-9718
   Abstract »    Full Text »    PDF »
Unmyelinated axons in the rat hippocampus hyperpolarize and activate an H current when spike frequency exceeds 1 Hz.
A F Soleng, K Chiu, and M Raastad (2003)
J. Physiol. 552, 459-470
   Abstract »    Full Text »    PDF »
Overexpression of a Hyperpolarization-Activated Cation Current (Ih) Channel Gene Modifies the Firing Activity of Identified Motor Neurons in a Small Neural Network.
Y. Zhang, R. Oliva, G. Gisselmann, H. Hatt, J. Guckenheimer, and R. M. Harris-Warrick (2003)
J. Neurosci. 23, 9059-9067
   Abstract »    Full Text »    PDF »
Enhanced Expression of a Specific Hyperpolarization-Activated Cyclic Nucleotide-Gated Cation Channel (HCN) in Surviving Dentate Gyrus Granule Cells of Human and Experimental Epileptic Hippocampus.
R. A. Bender, S. V. Soleymani, A. L. Brewster, S. T. Nguyen, H. Beck, G. W. Mathern, and T. Z. Baram (2003)
J. Neurosci. 23, 6826-6836
   Abstract »    Full Text »    PDF »
Heteromeric HCN1-HCN4 channels: a comparison with native pacemaker channels from the rabbit sinoatrial node.
C. Altomare, B. Terragni, C. Brioschi, R. Milanesi, C. Pagliuca, C. Viscomi, A. Moroni, M. Baruscotti, and D. DiFrancesco (2003)
J. Physiol. 549, 347-359
   Abstract »    Full Text »    PDF »
Synapse Number and Synaptic Efficacy Are Regulated by Presynaptic cAMP and Protein Kinase A.
D. W. Munno, D. J. Prince, and N. I. Syed (2003)
J. Neurosci. 23, 4146-4155
   Abstract »    Full Text »    PDF »
The Role of the Hyperpolarization-Activated Cationic Current Ih in the Timing of Interictal Bursts in the Neonatal Hippocampus.
A. Agmon and J. E. Wells (2003)
J. Neurosci. 23, 3658-3668
   Abstract »    Full Text »    PDF »
{kappa}-Opioid receptor-mediated enhancement of the hyperpolarization-activated current (Ih) through mobilization of intracellular calcium in rat nucleus raphe magnus.
Z. Z Pan (2003)
J. Physiol. 548, 765-775
   Abstract »    Full Text »    PDF »
Neuronal Hyperpolarization-Activated Pacemaker Channels Drive Neuropathic Pain.
S. R. Chaplan, H.-Q. Guo, D. H. Lee, L. Luo, C. Liu, C. Kuei, A. A. Velumian, M. P. Butler, S. M. Brown, and A. E. Dubin (2003)
J. Neurosci. 23, 1169-1178
   Abstract »    Full Text »    PDF »
Presynaptic Ca2+ Entry Is Unchanged during Hippocampal Mossy Fiber Long-Term Potentiation.
H. Kamiya, K. Umeda, S. Ozawa, and T. Manabe (2002)
J. Neurosci. 22, 10524-10528
   Abstract »    Full Text »    PDF »
Assessing the role of Ih channels in synaptic transmission and mossy fiber LTP.
V. Chevaleyre and P. E. Castillo (2002)
PNAS 99, 9538-9543
   Abstract »    Full Text »    PDF »
Current-dependent Block of Rabbit Sino-Atrial Node If Channels by Ivabradine.
A. Bucchi, M. Baruscotti, and D. DiFrancesco (2002)
J. Gen. Physiol. 120, 1-13
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)