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Science 21 December 2001:
Vol. 294. no. 5551, pp. 2542 - 2545
DOI: 10.1126/science.1066707
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Reports

Stem Cell Self-Renewal Specified by JAK-STAT Activation in Response to a Support Cell Cue

Amy A. Kiger,1*dagger D. Leanne Jones,1* Cordula Schulz,1 Madolyn B. Rogers,1 Margaret T. Fuller12ddagger

Stem cells generate many differentiated, short-lived cell types, such as blood, skin, and sperm, throughout adult life. Stem cells maintain a long-term capacity to divide, producing daughter cells that either self-renew or initiate differentiation. Although the surrounding microenvironment or "niche" influences stem cell fate decisions, few signals that emanate from the niche to specify stem cell self-renewal have been identified. Here we demonstrate that the apical hub cells in the Drosophila testis act as a cellular niche that supports stem cell self-renewal. Hub cells express the ligand Unpaired (Upd), which activates the Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway in adjacent germ cells to specify self-renewal and continual maintenance of the germ line stem cell population.

1 Department of Developmental Biology and
2 Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305-5329, USA.
*   These authors contributed equally to this work.

dagger    Present address: Department of Genetics, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA.

ddagger    To whom correspondence should be addressed at the Department of Developmental Biology, Beckman Center B300, 279 Campus Drive, Stanford University School of Medicine, Stanford, CA 94305-5329, USA. E-mail: fuller{at}cmgm.stanford.edu

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