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Science 30 November 2001:
Vol. 294. no. 5548, pp. 1875 - 1878
DOI: 10.1126/science.1065323
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Lysophospholipids--Receptor Revelations

Timothy Hla,* Menq-Jer Lee, Nicolas Ancellin, Ji H. Paik, Michael J. Kluk

Upon cell activation, membrane phospholipids are metabolized into potent lysophospholipid (LP) mediators, such as sphingosine 1-phosphate and lysophosphatidic acid. LPs fulfill signaling roles in organisms as diverse as yeast and humans. The recent discovery of G protein-coupled receptors for LPs in higher eukaryotes, and their involvement in regulating diverse processes such as angiogenesis, cardiac development, neuronal survival, and immunity, has stimulated growing interest in these lipid mediators. LP receptor biology has generated insights into fundamental cellular mechanisms and may provide therapeutic targets for drug development.

Center for Vascular Biology, Department of Physiology, University of Connecticut Health Center, Farmington, CT 06030-3501, USA.
*   To whom correspondence should be addressed. E-mail: hla{at}sun.uchc.edu.

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Autotaxin Hydrolyzes Sphingosylphosphorylcholine to Produce the Regulator of Migration, Sphingosine-1-Phosphate.
T. Clair, J. Aoki, E. Koh, R. W. Bandle, S. W. Nam, M. M. Ptaszynska, G. B. Mills, E. Schiffmann, L. A. Liotta, and M. L. Stracke (2003)
Cancer Res. 63, 5446-5453
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Ligand-dependent Inhibition of B16 Melanoma Cell Migration and Invasion via Endogenous S1P2 G Protein-coupled Receptor: REQUIREMENT OF INHIBITION OF CELLULAR RAC ACTIVITY.
K. Arikawa, N. Takuwa, H. Yamaguchi, N. Sugimoto, J. Kitayama, H. Nagawa, K. Takehara, and Y. Takuwa (2003)
J. Biol. Chem. 278, 32841-32851
   Abstract »    Full Text »    PDF »
Plaque Rupture, Lysophosphatidic Acid, and Thrombosis.
A. A. Spector (2003)
Circulation 108, 641-643
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Subtype-Selective Antagonists of Lysophosphatidic Acid Receptors Inhibit Platelet Activation Triggered by the Lipid Core of Atherosclerotic Plaques.
E. Rother, R. Brandl, D. L. Baker, P. Goyal, H. Gebhard, G. Tigyi, and W. Siess (2003)
Circulation 108, 741-747
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Lysophosphatidic Acid Signals through Mitogen-Activated Protein Kinase-Extracellular Signal Regulated Kinase in Ovarian Theca Cells Expressing the LPA1/edg2-Receptor: Involvement of a Nonclassical Pathway?.
L. T. Budnik, B. Brunswig-Spickenheier, and A. K. Mukhopadhyay (2003)
Mol. Endocrinol. 17, 1593-1606
   Abstract »    Full Text »    PDF »
Positive Modulation of IL-12 Signaling by Sphingosine Kinase 2 Associating with the IL-12 Receptor {beta}1 Cytoplasmic Region.
T. Yoshimoto, M. Furuhata, S. Kamiya, M. Hisada, H. Miyaji, Y. Magami, K. Yamamoto, H. Fujiwara, and J. Mizuguchi (2003)
J. Immunol. 171, 1352-1359
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Identification of p2y9/GPR23 as a Novel G Protein-coupled Receptor for Lysophosphatidic Acid, Structurally Distant from the Edg Family.
K. Noguchi, S. Ishii, and T. Shimizu (2003)
J. Biol. Chem. 278, 25600-25606
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Aspirin-Triggered Lipoxin A4 and B4 Analogs Block Extracellular Signal-Regulated Kinase-Dependent TNF-{alpha} Secretion from Human T Cells.
A. Ariel, N. Chiang, M. Arita, N. A. Petasis, and C. N. Serhan (2003)
J. Immunol. 170, 6266-6272
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Sphingosine 1-phosphate is a novel inhibitor of T-cell proliferation.
Y. Jin, E. Knudsen, L. Wang, Y. Bryceson, B. Damaj, S. Gessani, and A. A. Maghazachi (2003)
Blood 101, 4909-4915
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Sphingosine Phosphate Lyase Expression Is Essential for Normal Development in Caenorhabditis elegans.
J. Mendel, K. Heinecke, H. Fyrst, and J. D. Saba (2003)
J. Biol. Chem. 278, 22341-22349
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Bombesin, Lysophosphatidic Acid, and Epidermal Growth Factor Rapidly Stimulate Focal Adhesion Kinase Phosphorylation at Ser-910: REQUIREMENT FOR ERK ACTIVATION.
I. Hunger-Glaser, E. P. Salazar, J. Sinnett-Smith, and E. Rozengurt (2003)
J. Biol. Chem. 278, 22631-22643
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Agonist-induced endocytosis of lysophosphatidic acid-coupled LPA1/EDG-2 receptors via a dynamin2- and Rab5-dependent pathway.
M. M. Murph, L. A. Scaccia, L. A. Volpicelli, and H. Radhakrishna (2003)
J. Cell Sci. 116, 1969-1980
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The Lysophospholipid Receptor G2A Activates a Specific Combination of G Proteins and Promotes Apoptosis.
P. Lin and R. D. Ye (2003)
J. Biol. Chem. 278, 14379-14386
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Lysophosphatidylcholines prime the NADPH oxidase and stimulate multiple neutrophil functions through changes in cytosolic calcium.
C. C. Silliman, D. J. Elzi, D. R. Ambruso, R. J. Musters, C. Hamiel, R. J. Harbeck, A. J. Paterson, A. J. Bjornsen, T. H. Wyman, M. Kelher, et al. (2003)
J. Leukoc. Biol. 73, 511-524
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Human ALX receptor regulates neutrophil recruitment in transgenic mice: roles in inflammation and host defense.
P. R. DEVCHAND, M. ARITA, S. HONG, G. BANNENBERG, R.-L. MOUSSIGNAC, K. GRONERT, and C. N. SERHAN (2003)
FASEB J 17, 652-659
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