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Science 16 November 2001:
Vol. 294. no. 5546, pp. 1540 - 1543
DOI: 10.1126/science.1064890
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Reports

Induction of Dendritic Cell Differentiation by IFN-alpha in Systemic Lupus Erythematosus

Patrick Blanco,1* A. Karolina Palucka,1* Michelle Gill,12 Virginia Pascual,12 Jacques Banchereau1dagger

Dendritic cells (DCs) are important in regulating both immunity and tolerance. Hence, we hypothesized that systemic lupus erythematosus (SLE), an autoimmune disease characterized by autoreactive B and T cells, may be caused by alterations in the functions of DCs. Consistent with this, monocytes from SLE patients' blood were found to function as antigen-presenting cells, in vitro. Furthermore, serum from SLE patients induced normal monocytes to differentiate into DCs. These DCs could capture antigens from dying cells and present them to CD4-positive T cells. The capacity of SLE patients' serum to induce DC differentiation correlated with disease activity and depended on the actions of interferon-alpha (IFN-alpha ). Thus, unabated induction of DCs by IFN-alpha may drive the autoimmune response in SLE.

1 Baylor Institute for Immunology Research, Dallas, TX 75204, USA.
2 The University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA.
*   These authors contributed equally to this work.

dagger    To whom correspondence should be addressed. E-mail: j.banchereau{at}baylordallas.edu

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Very Low-Dose Tolerance with Nucleosomal Peptides Controls Lupus and Induces Potent Regulatory T Cell Subsets.
H.-K. Kang, M. A. Michaels, B. R. Berner, and S. K. Datta (2005)
J. Immunol. 174, 3247-3255
   Abstract »    Full Text »    PDF »
Defective B cell tolerance checkpoints in systemic lupus erythematosus.
S. Yurasov, H. Wardemann, J. Hammersen, M. Tsuiji, E. Meffre, V. Pascual, and M. C. Nussenzweig (2005)
J. Exp. Med. 201, 703-711
   Abstract »    Full Text »    PDF »
Cross-regulation of TNF and IFN-{alpha} in autoimmune diseases.
A. K. Palucka, J.-P. Blanck, L. Bennett, V. Pascual, and J. Banchereau (2005)
PNAS 102, 3372-3377
   Abstract »    Full Text »    PDF »
IFN-{alpha} Induces Early Lethal Lupus in Preautoimmune (New Zealand Black x New Zealand White)F1 but Not in BALB/c Mice.
A. Mathian, A. Weinberg, M. Gallegos, J. Banchereau, and S. Koutouzov (2005)
J. Immunol. 174, 2499-2506
   Abstract »    Full Text »    PDF »
Increased Blood Myeloid Dendritic Cells and Dendritic Cell-Poietins in Langerhans Cell Histiocytosis.
A. Rolland, L. Guyon, M. Gill, Y.-H. Cai, J. Banchereau, K. McClain, and A. K. Palucka (2005)
J. Immunol. 174, 3067-3071
   Abstract »    Full Text »    PDF »
Patients with active inflammatory bowel disease lack immature peripheral blood plasmacytoid and myeloid dendritic cells.
D C Baumgart, D Metzke, J Schmitz, A Scheffold, A Sturm, B Wiedenmann, and A U Dignass (2005)
Gut 54, 228-236
   Abstract »    Full Text »    PDF »
Plasmacytoid Dendritic Cells: Linking Innate and Adaptive Immunity.
K. McKenna, A.-S. Beignon, and N. Bhardwaj (2005)
J. Virol. 79, 17-27
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