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Science 9 November 2001:
Vol. 294. no. 5545, pp. 1358 - 1361
DOI: 10.1126/science.1064462
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Reports
Modulation of Blood Fluke Development in the Liver by Hepatic CD4+ Lymphocytes
Stephen J. Davies,1
Jane L. Grogan,2
Rebecca B. Blank,1
K. C. Lim,1
Richard M. Locksley,2
James H. McKerrow1*
We have identified an alternate developmental pathway in the life
cycle of the trematode pathogen Schistosoma mansoni. This pathway is used in immunodeficient hosts in which the parasite fails to
receive appropriate signals from the host immune system. Helminth
development is altered at an early stage during infection, resulting in
the appearance of attenuated forms that prolong survival of host and
parasite. Hepatic CD4+ T lymphocyte populations are an
integral component of the immune signal recognized by the parasite.
1 Tropical Disease Research Unit, Department of
Pathology, Veterans Affairs Medical Center,
2 Howard
Hughes Medical Institute, Department of Microbiology and Immunology,
University of California San Francisco, CA 94143, USA.
*
To whom correspondence should be addressed.
E-mail: jmck{at}cgl.ucsf.edu
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