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As late as the 1950s, it was assumed that communication between
nerve cells in the brain occurred predominantly, if not entirely,by
electrical impulses. A decade later, the theory of chemicaltransmission, which until then had been thought to occur onlyin the
peripheral nervous system, had gained strong entrance forthe central
nervous system. This paradigm shift opened up an enormousnew
perspective in brain research, not least by facilitating thestudy of
brain function by means of chemical tools, which in differentways
could modify the chemical signaling between nerve cells.Moreover, such
tools sometimes turned out to be useful as therapeuticagents. Thus for
the first time, a variety of disorders in thecentral nervous system
could be treated effectively.
Department of Pharmacology, University of Gothenburg, Gothenburg,
Sweden. E-mail: arvid.carlsson{at}pharm.gu.se *
This essay is adapted from the author's address to the Nobel
Foundation, December 2000.
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|Abstract »|Full Text »|PDF »
