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The Plasticity of Dendritic Cell Responses to Pathogens and Their Components
Qian Huang,1Dongyu Liu,1Paul Majewski,1Leah C. Schulte,1Joshua M. Korn,2Richard A. Young,12Eric S. Lander,123Nir Hacohen1*
Dendritic cells are involved in the initiation of both innate and
adaptive immunity. To systematically explore how dendriticcells
modulate the immune system in response to different pathogens,we used
oligonucleotide microarrays to measure gene expressionprofiles of
dendritic cells in response to Escherichia coli,
Candidaalbicans, and influenza virus as well as to their
molecular components.Both a shared core response and pathogen-specific
programs ofgene expression were observed upon exposure to each of
these pathogens.These results reveal that dendritic cells sense
diverse pathogensand elicit tailored pathogen-specific immune
responses.
1 Whitehead Institute for Biomedical Research,
Cambridge, MA 02142, USA.
2 Department of Biology,
Massachusetts Institute of Technology, Cambridge, MA 02142, USA.
3 Whitehead Institute Center for Genome Research, Cambridge,
MA 02139, USA.
*
To whom correspondence should be addressed. E-mail:
hacohen{at}wi.mit.edu
The editors suggest the following Related Resources on Science sites:
In Science Magazine
LETTERS
Robert L. Modlin and Barry R. Bloom (9 November 2001) Science294 (5545), 1279b.
[DOI: 10.1126/science.294.5545.1279b] |Full Text »
PERSPECTIVES
Robert L. Modlin and Barry R. Bloom (26 October 2001) Science294 (5543), 799.
[DOI: 10.1126/science.1066314] |Summary »|Full Text »|PDF »
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173, 531-541
|Abstract »|Full Text »|PDF »
Bacterial Probiotic Modulation of Dendritic Cells.
Distinct Transcriptional Programs Activated by Interleukin-10 with or without Lipopolysaccharide in Dendritic Cells: Induction of the B Cell-Activating Chemokine, CXC Chemokine Ligand 13.
P. Perrier, F. O. Martinez, M. Locati, G. Bianchi, M. Nebuloni, G. Vago, F. Bazzoni, S. Sozzani, P. Allavena, and A. Mantovani (2004)
J. Immunol.
172, 7031-7042
|Abstract »|Full Text »|PDF »
Flagellin Fusion Proteins as Adjuvants or Vaccines Induce Specific Immune Responses.
C. Cuadros, F. J. Lopez-Hernandez, A. L. Dominguez, M. McClelland, and J. Lustgarten (2004)
Infect. Immun.
72, 2810-2816
|Abstract »|Full Text »|PDF »
Controlling the Toll road to dendritic cell polarization.
Regulation of Dendritic Cell Function by NK Cells: Mechanisms Underlying the Synergism in the Combination Therapy of IL-12 and 4-1BB Activation.
P.-Y. Pan, P. Gu, Q. Li, D. Xu, K. Weber, and S.-H. Chen (2004)
J. Immunol.
172, 4779-4789
|Abstract »|Full Text »|PDF »
A Role for Toll-Like Receptor 4 in Dendritic Cell Activation and Cytolytic CD8+ T Cell Differentiation in Response to a Recombinant Heat Shock Fusion Protein.
D. Palliser, Q. Huang, N. Hacohen, S. P. Lamontagne, E. Guillen, R. A. Young, and H. N. Eisen (2004)
J. Immunol.
172, 2885-2893
|Abstract »|Full Text »|PDF »
A Type I IFN-Dependent Pathway Induced by Schistosoma mansoni Eggs in Mouse Myeloid Dendritic Cells Generates an Inflammatory Signature.
F. Trottein, N. Pavelka, C. Vizzardelli, V. Angeli, C. S. Zouain, M. Pelizzola, M. Capozzoli, M. Urbano, M. Capron, F. Belardelli, et al. (2004)
J. Immunol.
172, 3011-3017
|Abstract »|Full Text »|PDF »
Cutting Edge: Conventional CD8{alpha}+ Dendritic Cells Are Generally Involved in Priming CTL Immunity to Viruses.
G. T. Belz, C. M. Smith, D. Eichner, K. Shortman, G. Karupiah, F. R. Carbone, and W. R. Heath (2004)
J. Immunol.
172, 1996-2000
|Abstract »|Full Text »|PDF »
IL-10-Conditioned Dendritic Cells, Decommissioned for Recruitment of Adaptive Immunity, Elicit Innate Inflammatory Gene Products in Response to Danger Signals.
K. F. Nolan, V. Strong, D. Soler, P. J. Fairchild, S. P. Cobbold, R. Croxton, J.-A. Gonzalo, A. Rubio, M. Wells, and H. Waldmann (2004)
J. Immunol.
172, 2201-2209
|Abstract »|Full Text »|PDF »
Mycobacterium bovis BCG Cell Wall-Specific Differentially Expressed Genes Identified by Differential Display and cDNA Subtraction in Human Macrophages.
N. A. Begum, K. Ishii, M. Kurita-Taniguchi, M. Tanabe, M. Kobayashi, Y. Moriwaki, M. Matsumoto, Y. Fukumori, I. Azuma, K. Toyoshima, et al. (2004)
Infect. Immun.
72, 937-948
|Abstract »|Full Text »|PDF »
Gene expression in mature neutrophils: early responses to inflammatory stimuli.
X. Zhang, Y. Kluger, Y. Nakayama, R. Poddar, C. Whitney, A. DeTora, S. M. Weissman, and P. E. Newburger (2004)
J. Leukoc. Biol.
75, 358-372
|Abstract »|Full Text »|PDF »
Distinct Modulatory Effects of LPS and CpG on IL-18-Dependent IFN-{gamma} Synthesis.
M. P. Gould, J. A. Greene, V. Bhoj, J. L. DeVecchio, and F. P. Heinzel (2004)
J. Immunol.
172, 1754-1762
|Abstract »|Full Text »|PDF »
Gene Expression in HL60 Granulocytoids and Human Polymorphonuclear Leukocytes Exposed to Candida albicans{dagger}.
A. Mullick, M. Elias, P. Harakidas, A. Marcil, M. Whiteway, B. Ge, T. J. Hudson, A. W. Caron, L. Bourget, S. Picard, et al. (2004)
Infect. Immun.
72, 414-429
|Abstract »|Full Text »|PDF »
Interferon Regulatory Factor-3-mediated Activation of the Interferon-sensitive Response Element by Toll-like receptor (TLR) 4 but Not TLR3 Requires the p65 Subunit of NF-{kappa}.
C. Wietek, S. M. Miggin, C. A. Jefferies, and L. A. J. O'Neill (2003)
J. Biol. Chem.
278, 50923-50931
|Abstract »|Full Text »|PDF »
HIV-1 Nef triggers Vav-mediated signaling pathway leading to functional and morphological differentiation of dendritic cells.
M. G. QUARANTA, B. MATTIOLI, F. SPADARO, E. STRAFACE, L. GIORDANI, C. RAMONI, W. MALORNI, and M. VIORA (2003)
FASEB J
17, 2025-2036
|Abstract »|Full Text »|PDF »
Prostaglandin E2 inhibits production of the inflammatory chemokines CCL3 and CCL4 in dendritic cells.
