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Science 19 October 2001:
Vol. 294. no. 5542, pp. 610 - 612
DOI: 10.1126/science.1063775
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Reports

A Trypanosome Structure Involved in Transmitting Cytoplasmic Information During Cell Division

Flávia F. Moreira-Leite, Trevor Sherwin,* Linda Kohl,dagger Keith Gullddagger

African trypanosomes are protozoan parasites that cause sleeping sickness in humans through a tsetse fly vector. The procyclic form of Trypanosoma brucei has a single, attached flagellum that describes a helical path along the cell from posterior to anterior. During division, a specific flagellum-flagellum connection is elaborated between the new and old flagellum. This connector was present only during cell duplication and was found to be involved in the replication of the helical cell pattern and polarity. This finding implicates the concept of cytotaxis in cell morphogenesis in trypanosomes.

School of Biological Sciences, 2.205 Stopford Building, University of Manchester, Oxford Road, Manchester M13 9PT, UK.
*   Present address: Discipline of Ophthalmology, Faculty of Medicine and Health Sciences, University of Auckland, Auckland, New Zealand.

dagger    Present address: Muséum National d'Histoire Naturelle, Laboratoire de Biophysique, 43 rue Cuvier, 75231 Paris Cedex 05, France.

ddagger    To whom correspondence should be addressed. E-mail: k.gull{at}man.ac.uk

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Intraflagellar Transport and Functional Analysis of Genes Required for Flagellum Formation in Trypanosomes.
S. Absalon, T. Blisnick, L. Kohl, G. Toutirais, G. Dore, D. Julkowska, A. Tavenet, and P. Bastin (2008)
Mol. Biol. Cell 19, 929-944
   Abstract »    Full Text »    PDF »
Sphingolipid synthesis is necessary for kinetoplast segregation and cytokinesis in Trypanosoma brucei.
A. Fridberg, C. L. Olson, E. S. Nakayasu, K. M. Tyler, I. C. Almeida, and D. M. Engman (2008)
J. Cell Sci. 121, 522-535
   Abstract »    Full Text »    PDF »
The de Novo Synthesis of GDP-fucose Is Essential for Flagellar Adhesion and Cell Growth in Trypanosoma brucei.
D. C. Turnock, L. Izquierdo, and M. A. J. Ferguson (2007)
J. Biol. Chem. 282, 28853-28863
   Abstract »    Full Text »    PDF »
Sugar Nucleotide Pools of Trypanosoma brucei, Trypanosoma cruzi, and Leishmania major.
D. C. Turnock and M. A. J. Ferguson (2007)
Eukaryot. Cell 6, 1450-1463
   Abstract »    Full Text »    PDF »
Trypanosome IFT mutants provide insight into the motor location for mobility of the flagella connector and flagellar membrane formation.
J. A. Davidge, E. Chambers, H. A. Dickinson, K. Towers, M. L. Ginger, P. G. McKean, and K. Gull (2006)
J. Cell Sci. 119, 3935-3943
   Abstract »    Full Text »    PDF »
An Aurora Kinase Homologue Is Involved in Regulating Both Mitosis and Cytokinesis in Trypanosoma brucei.
X. Tu, P. Kumar, Z. Li, and C. C. Wang (2006)
J. Biol. Chem. 281, 9677-9687
   Abstract »    Full Text »    PDF »
Flagellar Motility Contributes to Cytokinesis in Trypanosoma brucei and Is Modulated by an Evolutionarily Conserved Dynein Regulatory System..
K. S. Ralston, A. G. Lerner, D. R. Diener, and K. L. Hill (2006)
Eukaryot. Cell 5, 696-711
   Abstract »    Full Text »    PDF »
Dissociation of Cytokinesis Initiation from Mitotic Control in a Eukaryote.
P. Kumar and C. C. Wang (2006)
Eukaryot. Cell 5, 92-102
   Abstract »    Full Text »    PDF »
The Parkin co-regulated gene product, PACRG, is an evolutionarily conserved axonemal protein that functions in outer-doublet microtubule morphogenesis.
H. R. Dawe, H. Farr, N. Portman, M. K. Shaw, and K. Gull (2005)
J. Cell Sci. 118, 5421-5430
   Abstract »    Full Text »    PDF »
Variant surface glycoprotein RNA interference triggers a precytokinesis cell cycle arrest in African trypanosomes.
K. Sheader, S. Vaughan, J. Minchin, K. Hughes, K. Gull, and G. Rudenko (2005)
PNAS 102, 8716-8721
   Abstract »    Full Text »    PDF »
An Evolutionarily Conserved Coiled-Coil Protein Implicated in Polycystic Kidney Disease Is Involved in Basal Body Duplication and Flagellar Biogenesis in Trypanosoma brucei.
G. W. Morgan, P. W. Denny, S. Vaughan, D. Goulding, T. R. Jeffries, D. F. Smith, K. Gull, and M. C. Field (2005)
Mol. Cell. Biol. 25, 3774-3783
   Abstract »    Full Text »    PDF »
Pairwise Knockdowns of cdc2-Related Kinases (CRKs) in Trypanosoma brucei Identified the CRKs for G1/S and G2/M Transitions and Demonstrated Distinctive Cytokinetic Regulations between Two Developmental Stages of the Organism.
X. Tu and C. C. Wang (2005)
Eukaryot. Cell 4, 755-764
   Abstract »    Full Text »    PDF »
The developmental cell biology of Trypanosoma brucei.
K. R. Matthews (2005)
J. Cell Sci. 118, 283-290
   Abstract »    Full Text »    PDF »
Coupling of Posterior Cytoskeletal Morphogenesis to the G1/S Transition in the Trypanosoma brucei Cell Cycle.
X. Tu and C. C. Wang (2005)
Mol. Biol. Cell 16, 97-105
   Abstract »    Full Text »    PDF »
The Involvement of Two cdc2-related Kinases (CRKs) in Trypanosoma brucei Cell Cycle Regulation and the Distinctive Stage-specific Phenotypes Caused by CRK3 Depletion.
X. Tu and C. C. Wang (2004)
J. Biol. Chem. 279, 20519-20528
   Abstract »    Full Text »    PDF »
The flagella connector of Trypanosoma brucei: an unusual mobile transmembrane junction.
L. J. Briggs, P. G. McKean, A. Baines, F. Moreira-Leite, J. Davidge, S. Vaughan, and K. Gull (2004)
J. Cell Sci. 117, 1641-1651
   Abstract »    Full Text »    PDF »
A PHO80-like Cyclin and a B-type Cyclin Control the Cell Cycle of the Procyclic Form of Trypanosoma brucei.
Z. Li and C. C. Wang (2003)
J. Biol. Chem. 278, 20652-20658
   Abstract »    Full Text »    PDF »
Biology and Mechanism of Trypanosome Cell Motility.
K. L. Hill (2003)
Eukaryot. Cell 2, 200-208
   Full Text »    PDF »
RNA Interference of Signal Peptide-binding Protein SRP54 Elicits Deleterious Effects and Protein Sorting Defects in Trypanosomes.
L. Liu, X.-h. Liang, S. Uliel, R. Unger, E. Ullu, and S. Michaeli (2002)
J. Biol. Chem. 277, 47348-47357
   Abstract »    Full Text »    PDF »
A Heritable Structural Alteration of the Yeast Mitochondrion.
D. Lockshon (2002)
Genetics 161, 1425-1435
   Abstract »    Full Text »    PDF »
Trypanosoma brucei FLA1 Is Required for Flagellum Attachment and Cytokinesis.
D. J. LaCount, B. Barrett, and J. E. Donelson (2002)
J. Biol. Chem. 277, 17580-17588
   Abstract »    Full Text »    PDF »
Galactose metabolism is essential for the African sleeping sickness parasite Trypanosoma brucei.
J. R. Roper, M. L. S. Guther, K. G. Milne, and M. A. J. Ferguson (2002)
PNAS 99, 5884-5889
   Abstract »    Full Text »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)