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Michael Girardi,1*David E. Oppenheim,2*Carrie R. Steele,2Julia M. Lewis,1Earl Glusac,1Renata Filler,1Paul Hobby,3Brian Sutton,3Robert E. Tigelaar,1Adrian C. Hayday2
The localization of T cells within epithelia suggests that
these cells may contribute to the down-regulation of epithelialmalignancies. We report that mice lacking cells are highlysusceptible to multiple regimens of cutaneous carcinogenesis.After
exposure to carcinogens, skin cells expressed Rae-1 andH60, major
histocompatibility complex-related molecules structurallyresembling
human MICA. Each of these is a ligand for NKG2d, areceptor expressed
by cytolytic T cells and natural killer (NK)cells. In vitro,
skin-associated NKG2d+ cells killed skin carcinoma
cells by a mechanism that wassensitive to blocking NKG2d engagement.
Thus, local T cells mayuse evolutionarily conserved proteins to
negatively regulate malignancy.
1 Department of Dermatology and Yale Skin Diseases
Research Core Center,
2 Peter Gorer Department of
Immunobiology, Guy's King's St. Thomas' Medical School,
3 Randall Centre for Molecular Medicine, Guy's Hospital,
King's College, London SE1 9RT, UK.
*
These authors contributed equally to this report.
To whom correspondence should be addressed. E-mail:
adrian.hayday{at}kcl.ac.uk
The editors suggest the following Related Resources on Science sites:
In Science Magazine
PERSPECTIVES
Drew M. Pardoll (19 October 2001) Science294 (5542), 534.
[DOI: 10.1126/science.1066284] |Summary »|Full Text »|PDF »
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T Cells
T cells within epithelia suggests that
these cells may contribute to the down-regulation of epithelial malignancies. We report that mice lacking