Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 5 October 2001:
Vol. 294. no. 5540, pp. 89 - 92
DOI: 10.1126/science.1066011

Viewpoint

Global Efforts in Structural Genomics

Raymond C. Stevens,1 Shigeyuki Yokoyama,2 Ian A. Wilson1

A worldwide initiative in structural genomics aims to capitalize on the recent successes of the genome projects. Substantial new investments in structural genomics in the past 2 years indicate the high level of support for these international efforts. Already, enormous progress has been made on high-throughput methodologies and technologies that will speed up macromolecular structure determinations. Recent international meetings have resulted in the formation of an International Structural Genomics Organization to formulate policy and foster cooperation between the public and private efforts.

1 Joint Center for Structural Genomics, Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
2 RIKEN Genomic Sciences Center, 1-7-22 Suehiro-cho, Tsurumi, Yokohama 230-0045, Japan.


Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
ParCrys: a Parzen window density estimation approach to protein crystallization propensity prediction.
I. M. Overton, G. Padovani, M. A. Girolami, and G. J. Barton (2008)
Bioinformatics 24, 901-907
   Abstract »    Full Text »    PDF »
Isotope-labeled Protein Standards: Toward Absolute Quantitative Proteomics.
V. Brun, A. Dupuis, A. Adrait, M. Marcellin, D. Thomas, M. Court, F. Vandenesch, and J. Garin (2007)
Mol. Cell. Proteomics 6, 2139-2149
   Abstract »    Full Text »    PDF »
Comprehensive genome analysis of 203 genomes provides structural genomics with new insights into protein family space.
R. L. Marsden, D. Lee, M. Maibaum, C. Yeats, and C. A. Orengo (2006)
Nucleic Acids Res. 34, 1066-1080
   Abstract »    Full Text »    PDF »
An efficient randomized algorithm for contact-based NMR backbone resonance assignment.
H. Kamisetty, C. Bailey-Kellogg, and G. Pandurangan (2006)
Bioinformatics 22, 172-180
   Abstract »    Full Text »    PDF »
DMAPS: a database of multiple alignments for protein structures.
C. Guda, L. R. Pal, and I. N. Shindyalov (2006)
Nucleic Acids Res. 34, D273-D276
   Abstract »    Full Text »    PDF »
Crystal structure of yeast YER010Cp, a knotable member of the RraA protein family.
N. Leulliot, S. Quevillon-Cheruel, M. Graille, M. Schiltz, K. Blondeau, J. Janin, and H. Van Tilbeurgh (2005)
Protein Sci. 14, 2751-2758
   Abstract »    Full Text »    PDF »
Identification of slow correlated motions in proteins using residual dipolar and hydrogen-bond scalar couplings.
G. Bouvignies, P. Bernado, S. Meier, K. Cho, S. Grzesiek, R. Bruschweiler, and M. Blackledge (2005)
PNAS 102, 13885-13890
   Abstract »    Full Text »    PDF »
Fold recognition aided by constraints from small angle X-ray scattering data.
W. Zheng and S. Doniach (2005)
Protein Eng. Des. Sel. 18, 209-219
   Abstract »    Full Text »    PDF »
Improvement of comparative model accuracy by free-energy optimization along principal components of natural structural variation.
B. Qian, A. R. Ortiz, and D. Baker (2004)
PNAS 101, 15346-15351
   Abstract »    Full Text »    PDF »
iMolTalk: an interactive, internet-based protein structure analysis server.
A. V. Diemand and H. Scheib (2004)
Nucleic Acids Res. 32, W512-W516
   Abstract »    Full Text »    PDF »
Distant Structural Homology Leads to the Functional Characterization of an Archaeal PIN Domain as an Exonuclease.
V. L. Arcus, K. Backbro, A. Roos, E. L. Daniel, and E. N. Baker (2004)
J. Biol. Chem. 279, 16471-16478
   Abstract »    Full Text »    PDF »
Rapid refinement of crystallographic protein construct definition employing enhanced hydrogen/deuterium exchange MS.
D. Pantazatos, J. S. Kim, H. E. Klock, R. C. Stevens, I. A. Wilson, S. A. Lesley, and V. L. Woods Jr. (2004)
PNAS 101, 751-756
   Abstract »    Full Text »    PDF »
Integrating Structure, Bioinformatics, and Enzymology to Discover Function: BioH, A NEW CARBOXYLESTERASE FROM ESCHERICHIA COLI.
R. Sanishvili, A. F. Yakunin, R. A. Laskowski, T. Skarina, E. Evdokimova, A. Doherty-Kirby, G. A. Lajoie, J. M. Thornton, C. H. Arrowsmith, A. Savchenko, et al. (2003)
J. Biol. Chem. 278, 26039-26045
   Abstract »    Full Text »    PDF »
A global representation of the protein fold space.
J. Hou, G. E. Sims, C. Zhang, and S.-H. Kim (2003)
PNAS 100, 2386-2390
   Abstract »    Full Text »    PDF »
On the evaluation and optimization of protein X-ray structures for pKa calculations.
J. E. Nielsen and J. A. McCammon (2003)
Protein Sci. 12, 313-326
   Abstract »    Full Text »    PDF »
Improving baculovirus recombination.
Y. Zhao, D. A. G. Chapman, and I. M. Jones (2003)
Nucleic Acids Res. 31, e6
   Abstract »    Full Text »    PDF »



ADVERTISEMENT
Click Me!

ADVERTISEMENT
Click Me!

To Advertise     Find Products


Science. ISSN 0036-8075 (print), 1095-9203 (online)