Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.
An Apolipoprotein Influencing Triglycerides in Humans and Mice Revealed by Comparative Sequencing
Len A. Pennacchio,1Michael Olivier,2*Jaroslav A. Hubacek,3Jonathan C. Cohen,3David R. Cox,2Jean-Charles Fruchart,4Ronald M. Krauss,1Edward M. Rubin1
Comparison of genomic DNA sequences from human and mouse revealed a
new apolipoprotein (APO) gene (APOAV) located
proximalto the well-characterized APOAI/CIII/AIV gene
cluster on human11q23. Mice expressing a human APOAV
transgene showed a decreasein plasma triglyceride concentrations to
one-third of those incontrol mice; conversely, knockout mice lacking
Apoav had fourtimes as much plasma triglycerides as
controls. In humans, singlenucleotide polymorphisms (SNPs) across the
APOAV locus were foundto be significantly associated with
plasma triglyceride levelsin two independent studies. These findings
indicate that APOAVis an important determinant of plasma triglyceride
levels, a majorrisk factor for coronary artery disease.
1 Genome Sciences Department, Lawrence Berkeley
National Laboratory, Berkeley, CA 94720, USA.
2 Stanford Human Genome Center, Department of
Genetics, Stanford University School of Medicine, 975 California
Avenue, Palo Alto, CA 94304, USA.
3 Center for Human
Nutrition and McDermott, Center for Human Growth and Development,
University of Texas Southwestern Medical Center, Dallas, TX
75390-9052, USA.
4 Department of
Atherosclerosis-INSERM U545, Institut Pasteur de Lille, 1, rue du
Professeur Calmette, 59019 Lille cedex, France and Faculté de
Pharmacie, University of Lille, 59006 Lille cedex, France.
*
Present address: Human and Molecular Genetics Center, Medical
College of Wisconsin, 8701 Watertown Plank Road, Milwaukee,WI 53226, USA.
To whom correspondence should be addressed. E-mail:
EMRubin{at}lbl.gov
The editors suggest the following Related Resources on Science sites:
In Science Magazine
NEWS OF THE WEEK
Caroline Seydel (5 October 2001) Science294 (5540), 33a.
[DOI: 10.1126/science.294.5540.33a] |Summary »|Full Text »|PDF »
INTRODUCTION TO SPECIAL ISSUE
Barbara R. Jasny and Leslie Roberts (5 October 2001) Science294 (5540), 81.
[DOI: 10.1126/science.294.5540.81] |Summary »|PDF »
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Genomic Susceptibility Loci for Brain Atrophy, Ventricular Volume, and Leukoaraiosis in Hypertensive Sibships.
S. T. Turner, M. Fornage, C. R. Jack Jr, T. H. Mosley, D. S. Knopman, S. L. R. Kardia, E. Boerwinkle, and M. de Andrade (2009)
Arch Neurol
66, 847-857
|Abstract »|Full Text »|PDF »
Association of Blood Lipids With Common DNA Sequence Variants at 19 Genetic Loci in the Multiethnic United States National Health and Nutrition Examination Survey III.
M. E. Keebler, C. L. Sanders, A. Surti, C. Guiducci, N. P. Burtt, and S. Kathiresan (2009)
Circ Cardiovasc Genet
2, 238-243
|Abstract »|Full Text »|PDF »
Plasma apolipoprotein AV levels in mice are positively associated with plasma triglyceride levels.
S. F. C. Vaessen, G. M. Dallinga-Thie, C. J. D. Ross, L. J. Splint, L. W. Castellani, P. C. N. Rensen, M. R. Hayden, F. G. Schaap, and J. A. Kuivenhoven (2009)
J. Lipid Res.
50, 880-884
|Abstract »|Full Text »|PDF »
Homologue of mammalian apolipoprotein A-II in non-mammalian vertebrates.
M. Choudhury, S. Yamada, M. Komatsu, H. Kishimura, and S. Ando (2009)
Acta Biochim Biophys Sin
41, 370-378
|Abstract »|Full Text »|PDF »
GPIHBP1, a GPI-anchored protein required for the lipolytic processing of triglyceride-rich lipoproteins.
A. P. Beigneux, B. S. J. Davies, A. Bensadoun, L. G. Fong, and S. G. Young (2009)
J. Lipid Res.
50, S57-S62
|Abstract »|Full Text »|PDF »
The ins (cell) and outs (plasma) of apolipoprotein A-V.
A PCSK9 variant and familial combined hyperlipidaemia.
M Abifadel, L Bernier, G Dubuc, G Nuel, J-P Rabes, J Bonneau, A Marques, M Marduel, M Devillers, A Munnich, et al. (2008)
J. Med. Genet.
45, 780-786
|Abstract »|Full Text »|PDF »
Investigation and management of hypertriglyceridaemia.
The Apolipoprotein CIII Enhancer Regulates Both Extensive Histone Modification and Intergenic Transcription of Human Apolipoprotien AI/CIII/AIV Genes but Not Apolipoprotein AV.
Y.-J. Li, Y.-S. Wei, X.-H. Fu, D.-L. Hao, Z. Xue, H. Gong, Z.-Q. Zhang, D.-P. Liu, and C.-C. Liang (2008)
J. Biol. Chem.
283, 28436-28444
|Abstract »|Full Text »|PDF »
Endocytosis of Apolipoprotein A-V by Members of the Low Density Lipoprotein Receptor and the Vps10p Domain Receptor Families.
S. K. Nilsson, S. Christensen, M. K. Raarup, R. O. Ryan, M. S. Nielsen, and G. Olivecrona (2008)
J. Biol. Chem.
283, 25920-25927
|Abstract »|Full Text »|PDF »
Atheroprotective Effect of Human Apolipoprotein A5 in a Mouse Model of Mixed Dyslipidemia.
R. M. Mansouri, E. Bauge, P. Gervois, J. Fruchart-Najib, C. Fievet, B. Staels, and J.-C. Fruchart (2008)
Circ. Res.
103, 450-453
|Abstract »|Full Text »|PDF »
An apolipoprotein A-V gene SNP is associated with marked hypertriglyceridemia among Asian-American patients.
C. R. Pullinger, B. E. Aouizerat, I. Movsesyan, V. Durlach, E. J. Sijbrands, K. Nakajima, A. Poon, G. M. Dallinga-Thie, H. Hattori, L. L. Green, et al. (2008)
J. Lipid Res.
49, 1846-1854
|Abstract »|Full Text »|PDF »
Intracellular lipid droplet targeting by apolipoprotein A-V requires the carboxyl-terminal segment.
Candidate genes for plasma triglyceride, FFA, and glucose revealed from an intercross between inbred mouse strains NZB/B1NJ and NZW/LacJ.
Z. Su, S.-w. Tsaih, J. Szatkiewicz, Y. Shen, and B. Paigen (2008)
J. Lipid Res.
49, 1500-1510
|Abstract »|Full Text »|PDF »
Influence of apoA-V gene variants on postprandial triglyceride metabolism: impact of gender.
E. Olano-Martin, E. C. Abraham, R. Gill-Garrison, A. M. Valdes, K. Grimaldi, F. Tang, K. G. Jackson, C. M. Williams, and A. M. Minihane (2008)
J. Lipid Res.
49, 945-953
|Abstract »|Full Text »|PDF »
Identification of a novel locus for triglyceride on chromosome 1p31-32 in families with premature CAD and MI.
S. B. Seidelmann, L. Li, G.-Q. Shen, E. J. Topol, and Q. K. Wang (2008)
J. Lipid Res.
49, 1034-1038
|Abstract »|Full Text »|PDF »
Effect of apolipoprotein A-V on plasma triglyceride, lipoprotein size, and composition in genetically engineered mice.
L. Nelbach, X. Shu, R. J. Konrad, R. O. Ryan, and T. M. Forte (2008)
J. Lipid Res.
49, 572-580
|Abstract »|Full Text »|PDF »
Qualifying the relationship between sequence conservation and molecular function.
Functional evolution of the p53 regulatory network through its target response elements.
A. G. Jegga, A. Inga, D. Menendez, B. J. Aronow, and M. A. Resnick (2008)
PNAS
105, 944-949
|Abstract »|Full Text »|PDF »
Genetic risk for metabolic syndrome: examination of candidate gene polymorphisms related to lipid metabolism in Japanese people.
Y Yamada, S Ichihara, K Kato, T Yoshida, K Yokoi, H Matsuo, S Watanabe, N Metoki, H Yoshida, K Satoh, et al. (2008)
J. Med. Genet.
45, 22-28
|Abstract »|Full Text »|PDF »
APOA5 variants and metabolic syndrome in Caucasians.
H. Grallert, E.-M. Sedlmeier, C. Huth, M. Kolz, I. M. Heid, C. Meisinger, C. Herder, K. Strassburger, A. Gehringer, M. Haak, et al. (2007)
J. Lipid Res.
48, 2614-2621
|Abstract »|Full Text »|PDF »
Increased concentrations of circulating vitamin E in carriers of the apolipoprotein A5 gene 1131T>C variant and associations with plasma lipids and lipid peroxidation.
I. Sundl, M. Guardiola, G. Khoschsorur, R. Sola, J. C. Vallve, G. Godas, L. Masana, M. Maritschnegg, A. Meinitzer, N. Cardinault, et al. (2007)
J. Lipid Res.
48, 2506-2513
|Abstract »|Full Text »|PDF »
Resequencing Genomic DNA of Patients With Severe Hypertriglyceridemia (MIM 144650).
J. Wang, H. Cao, M. R. Ban, B. A. Kennedy, S. Zhu, S. Anand, S. Yusuf, R. L. Pollex, and R. A. Hegele (2007)
Arterioscler. Thromb. Vasc. Biol.
27, 2450-2455
|Abstract »|Full Text »|PDF »
The Increase of Apolipoprotein A-V During Postprandial Lipemia Parallels the Response of Triglyceride-Rich Lipoproteins in Type 2 Diabetes: No relationship between apoA-V and postheparin plasma lipolytic activity.
J. Kahri, J. Fruchart-Najib, N. Matikainen, J.-C. Fruchart, J. Vakkilainen, and M.-R. Taskinen (2007)
Diabetes Care
30, 2083-2085
|Full Text »|PDF »
Avian apolipoprotein A-V binds to LDL receptor gene family members.
A. Dichlberger, L. A. Cogburn, J. Nimpf, and W. J. Schneider (2007)
J. Lipid Res.
48, 1451-1456
|Abstract »|Full Text »|PDF »
Effects of apoA-V on HDL and VLDL metabolism in APOC3 transgenic mice.
S. Qu, G. Perdomo, D. Su, F. M. D'Souza, N. S. Shachter, and H. H. Dong (2007)
J. Lipid Res.
48, 1476-1487
|Abstract »|Full Text »|PDF »
Apolipoprotein A-V association with intracellular lipid droplets.
X. Shu, J. Chan, R. O. Ryan, and T. M. Forte (2007)
J. Lipid Res.
48, 1445-1450
|Abstract »|Full Text »|PDF »
Clofibrate causes an upregulation of PPAR-{alpha} target genes but does not alter expression of SREBP target genes in liver and adipose tissue of pigs.
S. Luci, B. Giemsa, H. Kluge, and K. Eder (2007)
Am J Physiol Regulatory Integrative Comp Physiol
293, R70-R77
|Abstract »|Full Text »|PDF »
Apolipoprotein A-V Genetic Variation and Plasma Lipoprotein Response to Fibrates.
R. A. Hegele and R. L. Pollex (2007)
Arterioscler. Thromb. Vasc. Biol.
27, 1224-1227
|Full Text »|PDF »
Two Independent Apolipoprotein A5 Haplotypes Modulate Postprandial Lipoprotein Metabolism in a Healthy Caucasian Population.
R. Moreno-Luna, F. Perez-Jimenez, C. Marin, P. Perez-Martinez, P. Gomez, Y. Jimenez-Gomez, J. Delgado-Lista, J. A. Moreno, T. Tanaka, J. M. Ordovas, et al. (2007)
J. Clin. Endocrinol. Metab.
92, 2280-2285
|Abstract »|Full Text »|PDF »
Fenofibrate Effect on Triglyceride and Postprandial Response of Apolipoprotein A5 Variants: The GOLDN Study.
C.-Q. Lai, D. K. Arnett, D. Corella, R. J. Straka, M. Y. Tsai, J. M. Peacock, X. Adiconis, L. D. Parnell, J. E. Hixson, M. A. Province, et al. (2007)
Arterioscler. Thromb. Vasc. Biol.
27, 1417-1425
|Abstract »|Full Text »|PDF »
A Bayesian Multilocus Association Method: Allowing for Higher-Order Interaction in Association Studies.
A. Albrechtsen, S. Castella, G. Andersen, T. Hansen, O. Pedersen, and R. Nielsen (2007)
Genetics
176, 1197-1208
|Abstract »|Full Text »|PDF »
The C Terminus of Apolipoprotein A-V Modulates Lipid-binding Activity.
J. A. Beckstead, K. Wong, V. Gupta, C.-P. L. Wan, V. R. Cook, R. B. Weinberg, P. M. M. Weers, and R. O. Ryan (2007)
J. Biol. Chem.
282, 15484-15489
|Abstract »|Full Text »|PDF »
ECRbase: database of evolutionary conserved regions, promoters, and transcription factor binding sites in vertebrate genomes.
Evidence for a complex relationship between apoA-V and apoC-III in patients with severe hypertriglyceridemia.
F. G. Schaap, M. C. Nierman, J. F. P. Berbee, H. Hattori, P. J. Talmud, S. F. C. Vaessen, P. C. N. Rensen, R. A. F. M. Chamuleau, J. A. Kuivenhoven, and A. K. Groen (2006)
J. Lipid Res.
47, 2333-2339
|Abstract »|Full Text »|PDF »
Apolipoprotein A5 S19W May Play a Role in Dysbetalipoproteinemia in Patients with the Apo E2/E2 Genotype..
J. M. Martin-Campos, N. Rico, R. Bonet, C. Mayoral, J. Ordonez-Llanos, and F. Blanco-Vaca (2006)
Clin. Chem.
52, 1974-1975
|Full Text »|PDF »
Protease Inhibitor-Associated Dyslipidemia in HIV-Infected Patients Is Strongly Influenced by the APOA5-1131T->C Gene Variation.
M. Guardiola, R. Ferre, J. Salazar, C. Alonso-Villaverde, B. Coll, S. Parra, L. Masana, and J. Ribalta (2006)
Clin. Chem.
52, 1914-1919
|Abstract »|Full Text »|PDF »
Role of changes in cardiac metabolism in development of diabetic cardiomyopathy.
D. An and B. Rodrigues (2006)
Am J Physiol Heart Circ Physiol
291, H1489-H1506
|Abstract »|Full Text »|PDF »
Apolipoprotein A-V, triglycerides and risk of coronary artery disease: the prospective Epic-Norfolk Population Study.
S. F. C. Vaessen, F. G. Schaap, J.-A. Kuivenhoven, A. K. Groen, B. A. Hutten, S. M. Boekholdt, H. Hattori, M. S. Sandhu, S. A. Bingham, R. Luben, et al. (2006)
J. Lipid Res.
47, 2064-2070
|Abstract »|Full Text »|PDF »
Thematic review series: Systems Biology Approaches to Metabolic and Cardiovascular Disorders. Approaches to lipid metabolism gene identification and characterization in the postgenomic era.
Benefit of farnesoid X receptor inhibition in obstructive cholestasis.
C. Stedman, C. Liddle, S. Coulter, J. Sonoda, J. G. Alvarez, R. M. Evans, and M. Downes (2006)
PNAS
103, 11323-11328
|Abstract »|Full Text »|PDF »
Chicken genomics resource: sequencing and annotation of 35,407 ESTs from single and multiple tissue cDNA libraries and CAP3 assembly of a chicken gene index.
W. Carre, X. Wang, T. E. Porter, Y. Nys, J. Tang, E. Bernberg, R. Morgan, J. Burnside, S. E. Aggrey, J. Simon, et al. (2006)
Physiol Genomics
25, 514-524
|Abstract »|Full Text »|PDF »
Dietary Intake of n-6 Fatty Acids Modulates Effect of Apolipoprotein A5 Gene on Plasma Fasting Triglycerides, Remnant Lipoprotein Concentrations, and Lipoprotein Particle Size: The Framingham Heart Study.
C.-Q. Lai, D. Corella, S. Demissie, L. A. Cupples, X. Adiconis, Y. Zhu, L. D. Parnell, K. L. Tucker, and J. M. Ordovas (2006)
Circulation
113, 2062-2070
|Abstract »|Full Text »|PDF »
Variants at the APOA5 locus, association with carotid atherosclerosis, and modification by obesity: the Framingham Study.
R. Elosua, J. M. Ordovas, L. A. Cupples, C.-Q. Lai, S. Demissie, C. S. Fox, J. F. Polak, P. A. Wolf, R. B. D'Agostino Sr., and C. J. O'Donnell (2006)
J. Lipid Res.
47, 990-996
|Abstract »|Full Text »|PDF »
Characterization of a new mouse model for human apolipoprotein A-I/C-III/A-IV deficiency.
H. Mezdour, G. Larigauderie, G. Castro, G. Torpier, J. Fruchart, M. Nowak, J.-C. Fruchart, M. Rouis, and N. Maeda (2006)
J. Lipid Res.
47, 912-920
|Abstract »|Full Text »|PDF »
Conservation of RET Regulatory Function from Human to Zebrafish Without Sequence Similarity.
S. Fisher, E. A. Grice, R. M. Vinton, S. L. Bessling, and A. S. McCallion (2006)
Science
312, 276-279
|Abstract »|Full Text »|PDF »
Definitive N-terminal protein sequence and further characterization of the novel apolipoprotein a5 in human serum..
W. E. Alborn, M. G. Johnson, M. J. Prince, and R. J. Konrad (2006)
Clin. Chem.
52, 514-517
|Abstract »|Full Text »|PDF »
Trans-10, cis-12- and cis-9, trans-11-Conjugated Linoleic Acid Isomers Selectively Modify HDL-Apolipoprotein Composition in Apolipoprotein E Knockout Mice.
J. M. Arbones-Mainar, M. A. Navarro, S. Acin, M. A. Guzman, C. Arnal, J. C. Surra, R. Carnicer, H. M. Roche, and J. Osada (2006)
J. Nutr.
136, 353-359
|Abstract »|Full Text »|PDF »
Apolipoprotein A-V: a potential modulator of plasma triglyceride levels in Turks.
U. Hodoglugil, S. Tanyolac, D. W. Williamson, Y. Huang, and R. W. Mahley (2006)
J. Lipid Res.
47, 144-153
|Abstract »|Full Text »|PDF »
Evaluation of the RET regulatory landscape reveals the biological relevance of a HSCR-implicated enhancer.
E. A. Grice, E. S. Rochelle, E. D. Green, A. Chakravarti, and A. S. McCallion (2005)
Hum. Mol. Genet.
14, 3837-3845
|Abstract »|Full Text »|PDF »
APOC3/A5 haplotypes, lipid levels, and risk of myocardial infarction in the Central Valley of Costa Rica.
E. A. Ruiz-Narvaez, Y. Yang, Y. Nakanishi, J. Kirchdorfer, and H. Campos (2005)
J. Lipid Res.
46, 2605-2613
|Abstract »|Full Text »|PDF »
Apolipoprotein AV: Low Concentration, High Impact.
P. C.N. Rensen, K. W. van Dijk, and L. M. Havekes (2005)
Arterioscler. Thromb. Vasc. Biol.
25, 2445-2447
|Full Text »|PDF »
Hepatocyte Nuclear Factor-4{alpha} Regulates the Human Apolipoprotein AV Gene: Identification of a Novel Response Element and Involvement in the Control by Peroxisome Proliferator-Activated Receptor-{gamma} Coactivator-1{alpha}, AMP-Activated Protein Kinase, and Mitogen-Activated Protein Kinase Pathway.
X. Prieur, F. G. Schaap, H. Coste, and J. C. Rodriguez (2005)
Mol. Endocrinol.
19, 3107-3125
|Abstract »|Full Text »|PDF »
Apolipoprotein A-V Deficiency Results in Marked Hypertriglyceridemia Attributable to Decreased Lipolysis of Triglyceride-Rich Lipoproteins and Removal of Their Remnants.
I. Grosskopf, N. Baroukh, S.-J. Lee, Y. Kamari, D. Harats, E. M. Rubin, L. A. Pennacchio, and A. D. Cooper (2005)
Arterioscler. Thromb. Vasc. Biol.
25, 2573-2579
|Abstract »|Full Text »|PDF »
Dietary and Genetic Probes of Atherogenic Dyslipidemia.
Multiple QTLs influencing triglyceride and HDL and total cholesterol levels identified in families with atherogenic dyslipidemia.
Y. Yu, D. F. Wyszynski, D. M. Waterworth, S. D. Wilton, P. J. Barter, Y. A. Kesaniemi, R. W. Mahley, R. McPherson, G. Waeber, T. P. Bersot, et al. (2005)
J. Lipid Res.
46, 2202-2213
|Abstract »|Full Text »|PDF »
Human-zebrafish non-coding conserved elements act in vivo to regulate transcription.
J. T. Shin, J. R. Priest, I. Ovcharenko, A. Ronco, R. K. Moore, C. G. Burns, and C. A. MacRae (2005)
Nucleic Acids Res.
33, 5437-5445
|Abstract »|Full Text »|PDF »
A sandwich enzyme-linked immunosorbent assay for human plasma apolipoprotein A-V concentration.
M. Ishihara, T. Kujiraoka, T. Iwasaki, M. Nagano, M. Takano, J. Ishii, M. Tsuji, H. Ide, I. P. Miller, N. E. Miller, et al. (2005)
J. Lipid Res.
46, 2015-2022
|Abstract »|Full Text »|PDF »
Familial Combined Hyperlipidemia in Mexicans: Association With Upstream Transcription Factor 1 and Linkage on Chromosome 16q24.1.
A. Huertas-Vazquez, C. Aguilar-Salinas, A. J. Lusis, R. M. Cantor, S. Canizales-Quinteros, J. C. Lee, L. Mariana-Nunez, R.-M. L. Riba-Ramirez, A. Jokiaho, T. Tusie-Luna, et al. (2005)
Arterioscler. Thromb. Vasc. Biol.
25, 1985-1991
|Abstract »|Full Text »|PDF »
Determination of the Functionality of Common APOA5 Polymorphisms.
P. J. Talmud, J. Palmen, W. Putt, L. Lins, and S. E. Humphries (2005)
J. Biol. Chem.
280, 28215-28220
|Abstract »|Full Text »|PDF »
Administration of a PPAR{alpha} agonist increases serum apolipoprotein A-V levels and the apolipoprotein A-V/apolipoprotein C-III ratio.
A. E. Schultze, W. E. Alborn, R. K. Newton, and R. J. Konrad (2005)
J. Lipid Res.
46, 1591-1595
|Abstract »|Full Text »|PDF »
Thyroid Hormone Regulates the Hypotriglyceridemic Gene APOA5.
X. Prieur, T. Huby, H. Coste, F. G. Schaap, M. J. Chapman, and J. C. Rodriguez (2005)
J. Biol. Chem.
280, 27533-27543
|Abstract »|Full Text »|PDF »
Apolipoprotein A-V-heparin Interactions: IMPLICATIONS FOR PLASMA LIPOPROTEIN METABOLISM.
A. Lookene, J. A. Beckstead, S. Nilsson, G. Olivecrona, and R. O. Ryan (2005)
J. Biol. Chem.
280, 25383-25387
|Abstract »|Full Text »|PDF »
Validating a Rapid Method for Detecting Common Polymorphisms in the APOA5 Gene by Melting Curve Analysis Using LightTyper.
F. Frances, D. Corella, J. V. Sorli, M. Guillen, J. I. Gonzalez, and O. Portoles (2005)
Clin. Chem.
51, 1279-1282
|Full Text »|PDF »
Distribution and intensity of constraint in mammalian genomic sequence.
G. M. Cooper, E. A. Stone, G. Asimenos, NISC Comparative Sequencing Program, E. D. Green, S. Batzoglou, and A. Sidow (2005)
Genome Res.
15, 901-913
|Abstract »|Full Text »|PDF »
Hypertriglyceridemia: Interaction between APOE and APOAV Variants.
J. A. Hubacek, A. Horinek, Z. Skodova, V. Adamkova, R. Ceska, L. Zlatohlavek, and M. Vrablik (2005)
Clin. Chem.
51, 1311-1313
|Full Text »|PDF »
Apolipoprotein AV Accelerates Plasma Hydrolysis of Triglyceriderich Lipoproteins by Interaction with Proteoglycan-bound Lipoprotein Lipase.
M. Merkel, B. Loeffler, M. Kluger, N. Fabig, G. Geppert, L. A. Pennacchio, A. Laatsch, and J. Heeren (2005)
J. Biol. Chem.
280, 21553-21560
|Abstract »|Full Text »|PDF »
ApoA-V: The Regulation of a Regulator of Plasma Triglycerides.
Transcriptional Regulation of Apolipoprotein A5 Gene Expression by the Nuclear Receptor ROR{alpha}.
A. Genoux, H. Dehondt, A. Helleboid-Chapman, C. Duhem, D. W. Hum, G. Martin, L. A. Pennacchio, B. Staels, J. Fruchart-Najib, and J.-C. Fruchart (2005)
Arterioscler. Thromb. Vasc. Biol.
25, 1186-1192
|Abstract »|Full Text »|PDF »
The Expression of Intact and Mutant Human apoAI/CIII/AIV/AV Gene Cluster in Transgenic Mice.
J. Gao, Y. Wei, Y. Huang, D. Liu, G. Liu, M. Wu, L. Wu, Q. Zhang, Z. Zhang, R. Zhang, et al. (2005)
J. Biol. Chem.
280, 12559-12566
|Abstract »|Full Text »|PDF »
APOA5 polymorphisms influence plasma triglycerides in young, healthy African Americans and whites of the CARDIA Study.
K. L. E. Klos, S. Hamon, A. G. Clark, E. Boerwinkle, K. Liu, and C. F. Sing (2005)
J. Lipid Res.
46, 564-571
|Abstract »|Full Text »|PDF »
Whole-Genome Patterns of Common DNA Variation in Three Human Populations.
D. A. Hinds, L. L. Stuve, G. B. Nilsen, E. Halperin, E. Eskin, D. G. Ballinger, K. A. Frazer, and D. R. Cox (2005)
Science
307, 1072-1079
|Abstract »|Full Text »|PDF »
Insulin-Mediated Down-Regulation of Apolipoprotein A5 Gene Expression through the Phosphatidylinositol 3-Kinase Pathway: Role of Upstream Stimulatory Factor.
M. Nowak, A. Helleboid-Chapman, H. Jakel, G. Martin, D. Duran-Sandoval, B. Staels, E. M. Rubin, L. A. Pennacchio, M.-R. Taskinen, J. Fruchart-Najib, et al. (2005)
Mol. Cell. Biol.
25, 1537-1548
|Abstract »|Full Text »|PDF »
Apolipoprotein A5 and Hypertriglyceridemia.
V. Charlton-Menys and P. N. Durrington (2005)
Clin. Chem.
51, 295-297
|Full Text »|PDF »
Inherited Apolipoprotein A-V Deficiency in Severe Hypertriglyceridemia.
C. P. Oliva, L. Pisciotta, G. L. Volti, M. P. Sambataro, A. Cantafora, A. Bellocchio, A. Catapano, P. Tarugi, S. Bertolini, and S. Calandra (2005)
Arterioscler. Thromb. Vasc. Biol.
25, 411-417
|Abstract »|Full Text »|PDF »
The Novel Apolipoprotein A5 Is Present in Human Serum, Is Associated with VLDL, HDL, and Chylomicrons, and Circulates at Very Low Concentrations Compared with Other Apolipoproteins.
P. J. O'Brien, W. E. Alborn, J. H. Sloan, M. Ulmer, A. Boodhoo, M. D. Knierman, A. E. Schultze, and R. J. Konrad (2005)
Clin. Chem.
51, 351-359
|Abstract »|Full Text »|PDF »
Mulan: Multiple-sequence local alignment and visualization for studying function and evolution.
I. Ovcharenko, G. G. Loots, B. M. Giardine, M. Hou, J. Ma, R. C. Hardison, L. Stubbs, and W. Miller (2005)
Genome Res.
15, 184-194
|Abstract »|Full Text »|PDF »
Influence of the APOA5 locus on plasma triglyceride, lipoprotein subclasses, and CVD risk in the Framingham Heart Study.
C.-Q. Lai, S. Demissie, L. A. Cupples, Y. Zhu, X. Adiconis, L. D. Parnell, D. Corella, and J. M. Ordovas (2004)
J. Lipid Res.
45, 2096-2105
|Abstract »|Full Text »|PDF »
The Liver X Receptor Ligand T0901317 Down-regulates APOA5 Gene Expression through Activation of SREBP-1c.
H. Jakel, M. Nowak, E. Moitrot, H. Dehondt, D. W. Hum, L. A. Pennacchio, J. Fruchart-Najib, and J.-C. Fruchart (2004)
J. Biol. Chem.
279, 45462-45469
|Abstract »|Full Text »|PDF »
The -1131T->C polymorphism in the apolipoprotein A5 gene is associated with postprandial hypertriacylglycerolemia; elevated small, dense LDL concentrations; and oxidative stress in nonobese Korean men.
Y. Jang, J. Y. Kim, O. Y. Kim, J. E. Lee, H. Cho, J. M Ordovas, and J. H. Lee (2004)
Am. J. Clinical Nutrition
80, 832-840
|Abstract »|Full Text »|PDF »
Exploiting human-fish genome comparisons for deciphering gene regulation.
N. Ahituv, E. M. Rubin, and M. A. Nobrega (2004)
Hum. Mol. Genet.
13, R261-R266
|Abstract »|Full Text »|PDF »
Low-Density Lipoprotein Particle Size Loci in Familial Combined Hyperlipidemia: Evidence for Multiple Loci From a Genome Scan.
M. D. Badzioch, R. P. Igo Jr, F. Gagnon, J. D. Brunzell, R. M. Krauss, A. G. Motulsky, E. M. Wijsman, and G. P. Jarvik (2004)
Arterioscler. Thromb. Vasc. Biol.
24, 1942-1950
|Abstract »|Full Text »|PDF »
Liver X Receptors (LXRs) Regulate Apolipoprotein AIV-Implications of the Antiatherosclerotic Effect of LXR Agonists.
Y. Liang, X.-C. Jiang, R. Liu, G. Liang, T. P. Beyer, H. Gao, T. P. Ryan, S. Dan Li, P. I. Eacho, and G. Cao (2004)
Mol. Endocrinol.
18, 2000-2010
|Abstract »|Full Text »|PDF »
ApoAV Reduces Plasma Triglycerides by Inhibiting Very Low Density Lipoprotein-Triglyceride (VLDL-TG) Production and Stimulating Lipoprotein Lipase-mediated VLDL-TG Hydrolysis.
F. G. Schaap, P. C. N. Rensen, P. J. Voshol, C. Vrins, H. N. van der Vliet, R. A. F. M. Chamuleau, L. M. Havekes, A. K. Groen, and K. W. van Dijk (2004)
J. Biol. Chem.
279, 27941-27947
|Abstract »|Full Text »|PDF »
ECR Browser: a tool for visualizing and accessing data from comparisons of multiple vertebrate genomes.
I. Ovcharenko, M. A. Nobrega, G. G. Loots, and L. Stubbs (2004)
Nucleic Acids Res.
32, W280-W286
|Abstract »|Full Text »|PDF »
Analysis of Apolipoprotein A5, C3, and Plasma Triglyceride Concentrations in Genetically Engineered Mice.
N. Baroukh, E. Bauge, J. Akiyama, J. Chang, V. Afzal, J.-C. Fruchart, E. M. Rubin, J. Fruchart-Najib, and L. A. Pennacchio (2004)
Arterioscler. Thromb. Vasc. Biol.
24, 1297-1302
|Abstract »|Full Text »|PDF »
eShadow: A Tool for Comparing Closely Related Sequences.
I. Ovcharenko, D. Boffelli, and G. G. Loots (2004)
Genome Res.
14, 1191-1198
|Abstract »|Full Text »|PDF »
Haplotypes in the APOA1-C3-A4-A5 gene cluster affect plasma lipids in both humans and baboons.
Q.-f. Wang, X. Liu, J. O'Connell, Z. Peng, R. M. Krauss, D. L. Rainwater, J. L. VandeBerg, Edward. M. Rubin, J.-F. Cheng, and L. A. Pennacchio (2004)
Hum. Mol. Genet.
13, 1049-1056
|Abstract »|Full Text »|PDF »
Association of the APOLIPOPROTEIN A1/C3/A4/A5 Gene Cluster With Triglyceride Levels and LDL Particle Size in Familial Combined Hyperlipidemia.
R. Mar, P. Pajukanta, H. Allayee, M. Groenendijk, G. Dallinga-Thie, R. M. Krauss, J. S. Sinsheimer, R. M. Cantor, T. W.A. de Bruin, and A. J. Lusis (2004)
Circ. Res.
94, 993-999
|Abstract »|Full Text »|PDF »
APOA5 gene variants, lipoprotein particle distribution, and progression of coronary heart disease: results from the LOCAT study.
P. J. Talmud, S. Martin, M.-R. Taskinen, M. H. Frick, M. S. Nieminen, Y. A. Kesaniemi, A. Pasternack, S. E. Humphries, and M. Syvanne (2004)
J. Lipid Res.
45, 750-756
|Abstract »|Full Text »|PDF »
Genetics of familial combined hyperlipidemia and risk of coronary heart disease.
C.C. Shoulders, E.L. Jones, and R.P. Naoumova (2004)
Hum. Mol. Genet.
13, R149-160
|Abstract »|Full Text »|PDF »
zPicture: Dynamic Alignment and Visualization Tool for Analyzing Conservation Profiles.
I. Ovcharenko, G. G. Loots, R. C. Hardison, W. Miller, and L. Stubbs (2004)
Genome Res.
14, 472-477
|Abstract »|Full Text »|PDF »
Linkage and Association Between Distinct Variants of the APOA1/C3/A4/A5 Gene Cluster and Familial Combined Hyperlipidemia.
S. Eichenbaum-Voline, M. Olivier, E. L. Jones, R. P. Naoumova, B. Jones, B. Gau, H. N. Patel, M. Seed, D. J. Betteridge, D. J. Galton, et al. (2004)
Arterioscler. Thromb. Vasc. Biol.
24, 167-174
|Abstract »|Full Text »|PDF »
Comparative genomic analysis as a tool for biological discovery.
Identification and Characterization of Multi-Species Conserved Sequences.
E. H. Margulies, M. Blanchette, NISC Comparative Sequencing Program, D. Haussler, and E. D. Green (2003)
Genome Res.
13, 2507-2518
|Abstract »|Full Text »|PDF »
The APOA5 locus is a strong determinant of plasma triglyceride concentrations across ethnic groups in Singapore.
C.-Q. Lai, E-S. Tai, C. E. Tan, J. Cutter, S. K. Chew, Y.-P. Zhu, X. Adiconis, and J. M. Ordovas (2003)
J. Lipid Res.
44, 2365-2373
|Abstract »|Full Text »|PDF »
Apolipoprotein C-III, metabolic syndrome, and risk of coronary artery disease.
O. Olivieri, A. Bassi, C. Stranieri, E. Trabetti, N. Martinelli, F. Pizzolo, D. Girelli, S. Friso, P. F. Pignatti, and R. Corrocher (2003)
J. Lipid Res.
44, 2374-2381
|Abstract »|Full Text »|PDF »
A Combinatorial Network of Evolutionarily Conserved Myelin Basic Protein Regulatory Sequences Confers Distinct Glial-Specific Phenotypes.
H. F. Farhadi, P. Lepage, R. Forghani, H. C. H. Friedman, W. Orfali, L. Jasmin, W. Miller, T. J. Hudson, and A. C. Peterson (2003)
J. Neurosci.
23, 10214-10223
|Abstract »|Full Text »|PDF »
Confirmed Locus on Chromosome 11p and Candidate Loci on 6q and 8p for the Triglyceride and Cholesterol Traits of Combined Hyperlipidemia.
R. P. Naoumova, S. A. Bonney, S. Eichenbaum-Voline, H. N. Patel, B. Jones, E. L. Jones, J. Amey, S. Colilla, C. K.Y. Neuwirth, R. Allotey, et al. (2003)
Arterioscler. Thromb. Vasc. Biol.
23, 2070-2077
|Abstract »|Full Text »|PDF »
