Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.
AAAS Store

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 5 October 2001:
Vol. 294. no. 5540, pp. 137 - 141
DOI: 10.1126/science.294.5540.137
Prev | Table of Contents | Next

Reports

Submicrometer Metallic Barcodes

Sheila R. Nicewarner-Peña,1 R. Griffith Freeman,2 Brian D. Reiss,1 Lin He,2 David J. Peña,1 Ian D. Walton,2 Remy Cromer,2 Christine D. Keating,1* Michael J. Natan2*

We synthesized multimetal microrods intrinsically encoded with submicrometer stripes. Complex striping patterns are readily prepared by sequential electrochemical deposition of metal ions into templates with uniformly sized pores. The differential reflectivity of adjacent stripes enables identification of the striping patterns by conventional light microscopy. This readout mechanism does not interfere with the use of fluorescence for detection of analytes bound to particles by affinity capture, as demonstrated by DNA and protein bioassays.

1 Department of Chemistry, Pennsylvania State University, 152 Davey Laboratory, University Park, PA 16802, USA.
2 SurroMed Inc., 2375 Garcia Avenue, Mountain View, CA 94043, USA.
*   To whom correspondence should be addressed. E-mail: keating{at}chem.psu.edu, mnatan{at}surromed.com

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Cancer Immunomics Using Autoantibody Signatures for Biomarker Discovery.
M. Caron, G. Choquet-Kastylevsky, and R. Joubert-Caron (2007)
Mol. Cell. Proteomics 6, 1115-1122
   Abstract »    Full Text »    PDF »
Multifunctional Encoded Particles for High-Throughput Biomolecule Analysis.
D. C. Pregibon, M. Toner, and P. S. Doyle (2007)
Science 315, 1393-1396
   Abstract »    Full Text »    PDF »
Nanodiagnostics: A New Frontier for Clinical Laboratory Medicine.
H. M.E. Azzazy, M. M.H. Mansour, and S. C. Kazmierczak (2006)
Clin. Chem. 52, 1238-1246
   Abstract »    Full Text »    PDF »
On-Wire Lithography.
L. Qin, S. Park, L. Huang, and C. A. Mirkin (2005)
Science 309, 113-115
   Abstract »    Full Text »    PDF »
Simultaneous Determination of {alpha}-Fetoprotein and Free {beta}-Human Chorionic Gonadotropin by Element-Tagged Immunoassay with Detection by Inductively Coupled Plasma Mass Spectrometry.
S. Zhang, C. Zhang, Z. Xing, and X. Zhang (2004)
Clin. Chem. 50, 1214-1221
   Abstract »    Full Text »    PDF »
Decoding Randomly Ordered DNA Arrays.
K. L. Gunderson, S. Kruglyak, M. S. Graige, F. Garcia, B. G. Kermani, C. Zhao, D. Che, T. Dickinson, E. Wickham, J. Bierle, et al. (2004)
Genome Res. 14, 870-877
   Abstract »    Full Text »    PDF »
A Novel Encoded Particle Technology that Enables Simultaneous Interrogation of Multiple Cell Types.
O. Beske, J. Guo, J. Li, D. Bassoni, K. Bland, H. Marciniak, M. Zarowitz, V. Temov, I. Ravkin, and S. Goldbard (2004)
J Biomol Screen 9, 173-185
   Abstract »    PDF »
Self-Assembly of Mesoscopic Metal-Polymer Amphiphiles.
S. Park, J.-H. Lim, S.-W. Chung, and C. A. Mirkin (2004)
Science 303, 348-351
   Abstract »    Full Text »    PDF »
A Hybridization Model for the Plasmon Response of Complex Nanostructures.
E. Prodan, C. Radloff, N. J. Halas, and P. Nordlander (2003)
Science 302, 419-422
   Abstract »    Full Text »    PDF »
Rare earth-doped glass microbarcodes.
M. J. Dejneka, A. Streltsov, S. Pal, A. G. Frutos, C. L. Powell, K. Yost, P. K. Yuen, U. Muller, and J. Lahiri (2003)
PNAS 100, 389-393
   Abstract »    Full Text »    PDF »
Shape-Controlled Synthesis of Gold and Silver Nanoparticles.
Y. Sun and Y. Xia (2002)
Science 298, 2176-2179
   Abstract »    Full Text »    PDF »
Spontaneous Organization of Single CdTe Nanoparticles into Luminescent Nanowires.
Z. Tang, N. A. Kotov, and M. Giersig (2002)
Science 297, 237-240
   Abstract »    Full Text »    PDF »
Direct Patterning of Modified Oligonucleotides on Metals and Insulators by Dip-Pen Nanolithography.
L. M. Demers, D. S. Ginger, S.-J. Park, Z. Li, S.-W. Chung, and C. A. Mirkin (2002)
Science 296, 1836-1838
   Abstract »    Full Text »    PDF »
Array-Based Electrical Detection of DNA with Nanoparticle Probes.
S.-J. Park, T. A. Taton, and C. A. Mirkin (2002)
Science 295, 1503-1506
   Abstract »    Full Text »    PDF »


ADVERTISEMENT
Click Me!

ADVERTISEMENT
Click Me!

To Advertise     Find Products