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Originally published in Science Express on 16 August 2001
Science 14 September 2001:
Vol. 293. no. 5537, pp. 2111 - 2114
DOI: 10.1126/science.1061964
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Reports

An Essential Role for BAFF in the Normal Development of B Cells Through a BCMA-Independent Pathway

Barbara Schiemann,* Jennifer L. Gommerman, Kalpit Vora, Teresa G. Cachero, Svetlana Shulga-Morskaya, Max Dobles, Erica Frew, Martin L. Scottdagger

The B cell activating factor BAFF (BlyS/TALL-1/zTNF4) is a tumor necrosis factor (TNF)-related ligand that promotes B cell survival and binds to three receptors (BCMA, TACI, and the recently described BAFF-R). Here we report an absolute requirement for BAFF in normal B cell development. Examination of secondary lymphoid organs from BAFF-deficient mice revealed an almost complete loss of follicular and marginal zone B lymphocytes. In contrast, mice lacking BCMA had normal-appearing B lymphocyte compartments. BAFF therefore plays a crucial role in B cell development and can function through receptors other than BCMA.

Biogen, 14 Cambridge Center, Cambridge, MA 02142, USA.
*   Present address: National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA.

dagger    To whom correspondence should be addressed. E-mail: martin_scott{at}biogen.com

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BCMA Is Essential for the Survival of Long-lived Bone Marrow Plasma Cells.
B. P. O'Connor, V. S. Raman, L. D. Erickson, W. J. Cook, L. K. Weaver, C. Ahonen, L.-L. Lin, G. T. Mantchev, R. J. Bram, and R. J. Noelle (2004)
J. Exp. Med. 199, 91-98
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Chicken BAFF--a highly conserved cytokine that mediates B cell survival.
K. Schneider, S. Kothlow, P. Schneider, A. Tardivel, T. Gobel, B. Kaspers, and P. Staeheli (2004)
Int. Immunol. 16, 139-148
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EBV-Encoded Latent Membrane Protein 1 Cooperates with BAFF/BLyS and APRIL to Induce T Cell-Independent Ig Heavy Chain Class Switching.
B. He, N. Raab-Traub, P. Casali, and A. Cerutti (2003)
J. Immunol. 171, 5215-5224
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Actions of BAFF in B cell maturation and its effects on the development of autoimmune disease.
F Melchers (2003)
Ann Rheum Dis 62, ii25-27
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Normal Induction but Attenuated Progression of Germinal Center Responses in BAFF and BAFF-R Signaling-Deficient Mice.