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Originally published in Science Express on 16 August 2001
Science 14 September 2001:
Vol. 293. no. 5537, pp. 2111 - 2114
DOI: 10.1126/science.1061964
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Reports

An Essential Role for BAFF in the Normal Development of B Cells Through a BCMA-Independent Pathway

Barbara Schiemann,* Jennifer L. Gommerman, Kalpit Vora, Teresa G. Cachero, Svetlana Shulga-Morskaya, Max Dobles, Erica Frew, Martin L. Scottdagger

The B cell activating factor BAFF (BlyS/TALL-1/zTNF4) is a tumor necrosis factor (TNF)-related ligand that promotes B cell survival and binds to three receptors (BCMA, TACI, and the recently described BAFF-R). Here we report an absolute requirement for BAFF in normal B cell development. Examination of secondary lymphoid organs from BAFF-deficient mice revealed an almost complete loss of follicular and marginal zone B lymphocytes. In contrast, mice lacking BCMA had normal-appearing B lymphocyte compartments. BAFF therefore plays a crucial role in B cell development and can function through receptors other than BCMA.

Biogen, 14 Cambridge Center, Cambridge, MA 02142, USA.
*   Present address: National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA.

dagger    To whom correspondence should be addressed. E-mail: martin_scott{at}biogen.com

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Mol. Cell. Biol. 24, 4895-4908
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A therapeutic role for BLyS antagonists.
W Stohl (2004)
Lupus 13, 317-322
   Abstract »    PDF »
Engineering an APRIL-specific B Cell Maturation Antigen.
D. R. Patel, H. J. A. Wallweber, J. Yin, S. K. Shriver, S. A. Marsters, N. C. Gordon, M. A. Starovasnik, and R. F. Kelley (2004)
J. Biol. Chem. 279, 16727-16735
   Abstract »    Full Text »    PDF »
Impaired IgA class switching in APRIL-deficient mice.
E. Castigli, S. Scott, F. Dedeoglu, P. Bryce, H. Jabara, A. K. Bhan, E. Mizoguchi, and R. S. Geha (2004)
PNAS 101, 3903-3908
   Abstract »    Full Text »    PDF »
BAFF/BLyS can potentiate B-cell selection with the B-cell coreceptor complex.
H. Hase, Y. Kanno, M. Kojima, K. Hasegawa, D. Sakurai, H. Kojima, N. Tsuchiya, K. Tokunaga, N. Masawa, M. Azuma, et al. (2004)
Blood 103, 2257-2265
   Abstract »    Full Text »    PDF »
Lymphoma B Cells Evade Apoptosis through the TNF Family Members BAFF/BLyS and APRIL.
B. He, A. Chadburn, E. Jou, E. J. Schattner, D. M. Knowles, and A. Cerutti (2004)
J. Immunol. 172, 3268-3279
   Abstract »    Full Text »    PDF »
APRIL-Deficient Mice Have Normal Immune System Development.
E. Varfolomeev, F. Kischkel, F. Martin, D. Seshasayee, H. Wang, D. Lawrence, C. Olsson, L. Tom, S. Erickson, D. French, et al. (2004)
Mol. Cell. Biol. 24, 997-1006
   Abstract »    Full Text »    PDF »
Cutting Edge: BAFF Regulates CD21/35 and CD23 Expression Independent of Its B Cell Survival Function.
L. Gorelik, A. H. Cutler, G. Thill, S. D. Miklasz, D. E. Shea, C. Ambrose, S. A. Bixler, L. Su, M. L. Scott, and S. L. Kalled (2004)
J. Immunol. 172, 762-766
   Abstract »    Full Text »    PDF »
TNF Deficiency Fails to Protect BAFF Transgenic Mice against Autoimmunity and Reveals a Predisposition to B Cell Lymphoma.
M. Batten, C. Fletcher, L. G. Ng, J. Groom, J. Wheway, Y. Laabi, X. Xin, P. Schneider, J. Tschopp, C. R. Mackay, et al. (2004)
J. Immunol. 172, 812-822
   Abstract »    Full Text »    PDF »
Involvement of BAFF and APRIL in the resistance to apoptosis of B-CLL through an autocrine pathway.
C. Kern, J.-F. Cornuel, C. Billard, R. Tang, D. Rouillard, V. Stenou, T. Defrance, F. Ajchenbaum-Cymbalista, P.-Y. Simonin, S. Feldblum, et al. (2004)
Blood 103, 679-688
   Abstract »    Full Text »    PDF »
BCMA Is Essential for the Survival of Long-lived Bone Marrow Plasma Cells.
B. P. O'Connor, V. S. Raman, L. D. Erickson, W. J. Cook, L. K. Weaver, C. Ahonen, L.-L. Lin, G. T. Mantchev, R. J. Bram, and R. J. Noelle (2004)
J. Exp. Med. 199, 91-98
   Abstract »    Full Text »    PDF »
Chicken BAFF--a highly conserved cytokine that mediates B cell survival.
K. Schneider, S. Kothlow, P. Schneider, A. Tardivel, T. Gobel, B. Kaspers, and P. Staeheli (2004)
Int. Immunol. 16, 139-148
   Abstract »    Full Text »    PDF »
EBV-Encoded Latent Membrane Protein 1 Cooperates with BAFF/BLyS and APRIL to Induce T Cell-Independent Ig Heavy Chain Class Switching.
B. He, N. Raab-Traub, P. Casali, and A. Cerutti (2003)
J. Immunol. 171, 5215-5224
   Abstract »    Full Text »    PDF »
Actions of BAFF in B cell maturation and its effects on the development of autoimmune disease.
F Melchers (2003)
Ann Rheum Dis 62, ii25-27
   Abstract »    Full Text »    PDF »


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