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Originally published in Science Express on 16 August 2001
Science 14 September 2001:
Vol. 293. no. 5537, pp. 2108 - 2111
DOI: 10.1126/science.1061965
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Reports

BAFF-R, a Newly Identified TNF Receptor That Specifically Interacts with BAFF

Jeffrey S. Thompson,1 Sarah A. Bixler,1 Fang Qian,1 Kalpit Vora,1* Martin L. Scott,1 Teresa G. Cachero,1 Catherine Hession,1 Pascal Schneider,2 Irene D. Sizing,1 Colleen Mullen,1 Kathy Strauch,1 Mohammad Zafari,1 Christopher D. Benjamin,1 Jurg Tschopp,2 Jeffrey L. Browning,1 Christine Ambrose1dagger

B cell homeostasis has been shown to critically depend on BAFF, the B cell activation factor from the tumor necrosis factor (TNF) family. Although BAFF is already known to bind two receptors, BCMA and TACI, we have identified a third receptor for BAFF that we have termed BAFF-R. BAFF-R binding appears to be highly specific for BAFF, suggesting a unique role for this ligand-receptor interaction. Consistent with this, the BAFF-R locus is disrupted in A/WySnJ mice, which display a B cell phenotype qualitatively similar to that of the BAFF-deficient mice. Thus, BAFF-R appears to be the principal receptor for BAFF-mediated mature B cell survival.

1 Biogen, 12 Cambridge Center, Cambridge, MA 02142, USA.
2 The Institute of Biochemistry, University of Lausanne, CH-1066, Epalinges, Switzerland.
*   Present address: Department of Biologics Research, Merck & Co., 126 East Lincoln Avenue, RY 80Y-310, Rahway, NJ 07065, USA.

dagger    To whom correspondence should be addressed. E-mail: christine_ambrose{at}biogen.com

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