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Science 14 September 2001:
Vol. 293. no. 5537, pp. 2087 - 2092
DOI: 10.1126/science.1061603
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Reports

A Gene Expression Map for Caenorhabditis elegans

Stuart K. Kim,1* Jim Lund,1 Moni Kiraly,1 Kyle Duke,1 Min Jiang,1 Joshua M. Stuart,2 Andreas Eizinger,1 Brian N. Wylie,3 George S. Davidson3

We have assembled data from Caenorhabditis elegans DNA microarray experiments involving many growth conditions, developmental stages, and varieties of mutants. Co-regulated genes were grouped together and visualized in a three-dimensional expression map that displays correlations of gene expression profiles as distances in two dimensions and gene density in the third dimension. The gene expression map can be used as a gene discovery tool to identify genes that are co-regulated with known sets of genes (such as heat shock, growth control genes, germ line genes, and so forth) or to uncover previously unknown genetic functions (such as genomic instability in males and sperm caused by specific transposons).

1 Department of Developmental Biology and Genetics, Stanford University Medical School, Stanford, CA 94305, USA.
2 Stanford Medical Informatics, 251 Campus Drive, MSOB X-215, Stanford, CA 94305, USA.
3 Computation, Computers and Mathematics Center, Sandia National Laboratories, Albuquerque, NM 87185-0318, USA.
*   To whom correspondence should be addressed. E-mail: kim{at}cmgm.stanford.edu

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