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Science 10 August 2001:
Vol. 293. no. 5532, pp. 1098 - 1102
DOI: 10.1126/science.1062939
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The Centromere Paradox: Stable Inheritance with Rapidly Evolving DNA

Steven Henikoff,* Kami Ahmad, Harmit S. Malik

Every eukaryotic chromosome has a centromere, the locus responsible for poleward movement at mitosis and meiosis. Although conventional loci are specified by their DNA sequences, current evidence favors a chromatin-based inheritance mechanism for centromeres. The chromosome segregation machinery is highly conserved across all eukaryotes, but the DNA and protein components specific to centromeric chromatin are evolving rapidly. Incompatibilities between rapidly evolving centromeric components may be responsible for both the organization of centromeric regions and the reproductive isolation of emerging species.

Howard Hughes Medical Institute Research Laboratories, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109, USA.
*   To whom correspondence should be addressed. E-mail: steveh{at}fhcrc.org

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