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Science 10 August 2001:
Vol. 293. no. 5532, pp. 1089 - 1093
DOI: 10.1126/science.1063443
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Review

Epigenetic Reprogramming in Mammalian Development

Wolf Reik,1* Wendy Dean,1 Jörn Walter2

DNA methylation is a major epigenetic modification of the genome that regulates crucial aspects of its function. Genomic methylation patterns in somatic differentiated cells are generally stable and heritable. However, in mammals there are at least two developmental periods--in germ cells and in preimplantation embryos--in which methylation patterns are reprogrammed genome wide, generating cells with a broad developmental potential. Epigenetic reprogramming in germ cells is critical for imprinting; reprogramming in early embryos also affects imprinting. Reprogramming is likely to have a crucial role in establishing nuclear totipotency in normal development and in cloned animals, and in the erasure of acquired epigenetic information. A role of reprogramming in stem cell differentiation is also envisaged.

1 Laboratory of Developmental Genetics and Imprinting, The Babraham Institute, Cambridge CB2 4AT, UK.
2 Universität des Saarlandes, Fr 8.2 Genetik, 66041 Saarbrücken, Germany.
*   To whom correspondence should be addressed. E-mail: wolf.reik{at}bbsrc.ac.uk

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