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Science 10 August 2001:
Vol. 293. no. 5532, pp. 1080 - 1083
DOI: 10.1126/science.1063051
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RNA: Guiding Gene Silencing

Marjori Matzke,1* Antonius J. M. Matzke,1 Jan M. Kooter2

In diverse organisms, small RNAs derived from cleavage of double-stranded RNA can trigger epigenetic gene silencing in the cytoplasm and at the genome level. Small RNAs can guide posttranscriptional degradation of complementary messenger RNAs and, in plants, transcriptional gene silencing by methylation of homologous DNA sequences. RNA silencing is a potent means to counteract foreign sequences and could play an important role in plant and animal development.

1 Institute of Molecular Biology, Austrian Academy of Sciences, A-5020 Salzburg, Austria.
2 Department of Developmental Genetics, Vrije Universiteit, Amsterdam, Netherlands.
*   To whom correspondence should be addressed. E-mail: mmatzke{at}imb.oeaw.ac.at

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