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Science 6 July 2001:
Vol. 293. no. 5527, pp. 82 - 85
DOI: 10.1126/science.1061498
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Reports

Approach to High-Resolution ex Situ NMR Spectroscopy

Carlos A. Meriles, Dimitris Sakellariou, Henrike Heise, Adam J. Moulé, Alexander Pines*

Nuclear magnetic resonance (NMR) experiments are typically performed with samples immersed in a magnet shimmed to high homogeneity. However, there are many circumstances in which it is impractical or undesirable to insert objects or subjects into the bore of a high-field magnet. Here we present a methodology based on an adaptation of nutation echoes that provides resolved spectra in the presence of matched inhomogeneous static and radiofrequency fields, thereby opening the way to high-resolution ex situ NMR. The observation of chemical shifts is regained through the use of multiple-pulse sequences of correlated, composite z-rotation pulses, producing resolved NMR spectra of liquid samples.

Materials Sciences Division, Lawrence Berkeley National Laboratory and Department of Chemistry, University of California, Berkeley, CA 94720, USA.
*   To whom correspondence should be addressed.

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