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Science 6 July 2001:
Vol. 293. no. 5527, pp. 111 - 115
DOI: 10.1126/science.1058379
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Reports

Ventroptin: A BMP-4 Antagonist Expressed in a Double-Gradient Pattern in the Retina

Hiraki Sakuta,1 Ryoko Suzuki,13 Hiroo Takahashi,13 Akira Kato,13 Takafumi Shintani,13 Shun-ichiro Iemura,2 Takamasa S. Yamamoto,2 Naoto Ueno,23 Masaharu Noda13*

In the visual system, the establishment of the anteroposterior and dorsoventral axes in the retina and tectum during development is important for topographic retinotectal projection. We identified chick Ventroptin, an antagonist of bone morphogenetic protein 4 (BMP-4), which is mainly expressed in the ventral retina, not only with a ventral high-dorsal low gradient but also with a nasal high-temporal low gradient at later stages. Misexpression of Ventroptin altered expression patterns of several topographic genes in the retina and projection of the retinal axons to the tectum along both axes. Thus, the topographic retinotectal projection appears to be specified by the double-gradient molecule Ventroptin along the two axes.

1 Division of Molecular Neurobiology, National Institute for Basic Biology,
2 Division of Morphogenesis, National Institute for Basic Biology,
3 Department of Molecular Biomechanics, The Graduate University for Advanced Studies, 38 Nishigonaka, Myodaiji-cho, Okazaki 444-8585, Japan.
*   To whom correspondence should be addressed. E-mail: madon{at}nibb.ac.jp

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