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Science 8 June 2001:
Vol. 292. no. 5523, pp. 1915 - 1918
DOI: 10.1126/science.1058889
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Reports

In Silico Mapping of Complex Disease-Related Traits in Mice

Andrew Grupe,1* Soren Germer,2* Jonathan Usuka,3* Dee Aud,1 John K. Belknap,4 Robert F. Klein,4 Mandeep K. Ahluwalia,2 Russell Higuchi,2 Gary Peltz1dagger

Experimental murine genetic models of complex human disease show great potential for understanding human disease pathogenesis. To reduce the time required for analysis of such models from many months down to milliseconds, a computational method for predicting chromosomal regions regulating phenotypic traits and a murine database of single nucleotide polymorphisms were developed. After entry of phenotypic information obtained from inbred mouse strains, the phenotypic and genotypic information is analyzed in silico to predict the chromosomal regions regulating the phenotypic trait.

1 Department of Genetics and Genomics, Roche Bioscience, Palo Alto, CA 94303, USA.
2 Roche Molecular Systems, Alameda, CA 94501, USA.
3 Department of Chemistry, Stanford University, Stanford, CA 94305-5080, USA.
4 Oregon Health Sciences University and Portland Veterans Affairs Medical Center, Portland, OR 97201, USA.
*   These authors contributed equally to this work.

dagger    To whom correspondence should be addressed: gary.peltz{at}roche.com

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