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A Transgenic Model for Listeriosis: Role of Internalin in Crossing the Intestinal Barrier
Marc Lecuit,1Sandrine Vandormael-Pournin,2Jean Lefort,3Michel Huerre,4Pierre Gounon,5Catherine Dupuy,1Charles Babinet,2Pascale Cossart1*
Listeria monocytogenes is responsible
for severe food-borne infections, but the mechanisms by which bacteria
cross the intestinalbarrier are unknown. Listeria
monocytogenes expresses a surfaceprotein, internalin, that
interacts with a host receptor, E-cadherin,to promote entry into human
epithelial cells. Murine E-cadherin,in contrast to guinea pig
E-cadherin, does not interact with internalin,excluding the mouse as a
model for addressing internalin functionin vivo. In guinea pigs and
transgenic mice expressing human E-cadherin,internalin was found to
mediate invasion of enterocytes and crossingof the intestinal barrier.
These results illustrate how relevantanimal models for human
infections can be generated.
1 Unité des Interactions
Bactéries-Cellules,
2 Unité de Biologie
du Développement, Unité de Recherche Associée CNRS
1960,
3 Unité de Pharmacologie Cellulaire,
4 Unité d'Histopathologie,
5 Station Centrale de Microscopie Electronique,
Institut Pasteur, 75724 Paris cedex 15, France.
*
To whom correspondence should be addressed. E-mail:
pcossart{at}pasteur.fr
The editors suggest the following Related Resources on Science sites:
In Science Magazine
PERSPECTIVES
B. Brett Finlay (1 June 2001) Science292 (5522), 1665.
[DOI: 10.1126/science.1062045] |Summary »|Full Text »
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