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Pot1, the Putative Telomere End-Binding Protein in Fission Yeast and Humans
Peter Baumann,Thomas R. Cech*
Telomere proteins from ciliated protozoa bind to the
single-stranded G-rich DNA extensions at the ends of macronuclear
chromosomes.We have now identified homologous proteins in fission
yeast andin humans. These Pot1 (rotection f
elomeres) proteins eachbind the G-rich strand of their
own telomeric repeat sequence,consistent with a direct role in
protecting chromosome ends. Deletionof the fission yeast
pot1+ gene has an immediate effect on chromosome
stability, causingrapid loss of telomeric DNA and chromosome
circularization. Itnow appears that the protein that caps the ends of
chromosomesis widely dispersed throughout the eukaryotic kingdom.
Howard Hughes Medical Institute, Department of Chemistry and
Biochemistry, University of Colorado, Boulder, CO 80309, USA.
*
To whom correspondence should be addressed. E-mail:
thomas.cech{at}colorado.edu
The editors suggest the following Related Resources on Science sites:
In Science Magazine
PERSPECTIVES
Titia de Lange (11 May 2001) Science292 (5519), 1075.
[DOI: 10.1126/science.1061032] |Summary »|Full Text »
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