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Science 11 May 2001:
Vol. 292. no. 5519, pp. 1171 - 1175
DOI: 10.1126/science.1060036
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Reports

Pot1, the Putative Telomere End-Binding Protein in Fission Yeast and Humans

Peter Baumann, Thomas R. Cech*

Telomere proteins from ciliated protozoa bind to the single-stranded G-rich DNA extensions at the ends of macronuclear chromosomes. We have now identified homologous proteins in fission yeast and in humans. These Pot1 (<UNL>p</UNL>rotection <UNL>o</UNL>f <UNL>t</UNL>elomeres) proteins each bind the G-rich strand of their own telomeric repeat sequence, consistent with a direct role in protecting chromosome ends. Deletion of the fission yeast pot1+ gene has an immediate effect on chromosome stability, causing rapid loss of telomeric DNA and chromosome circularization. It now appears that the protein that caps the ends of chromosomes is widely dispersed throughout the eukaryotic kingdom.

Howard Hughes Medical Institute, Department of Chemistry and Biochemistry, University of Colorado, Boulder, CO 80309, USA.
*   To whom correspondence should be addressed. E-mail: thomas.cech{at}colorado.edu

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Distinct Requirements for Pot1 in Limiting Telomere Length and Maintaining Chromosome Stability.
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Carcinogenesis 25, 1083-1087
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K. A. Mattern, S. J. J. Swiggers, A. L. Nigg, B. Lowenberg, A. B. Houtsmuller, and J. M. J. M. Zijlmans (2004)
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K. Myung, G. Ghosh, F. J. Fattah, G. Li, H. Kim, A. Dutia, E. Pak, S. Smith, and E. A. Hendrickson (2004)
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A. K. Meeker, J. L. Hicks, C. A. Iacobuzio-Donahue, E. A. Montgomery, W. H. Westra, T. Y. Chan, B. M. Ronnett, and A. M. De Marzo (2004)
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C. Kwon and I. K. Chung (2004)
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Importance of TRF1 for Functional Telomere Structure.
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Cancer Res. 63, 7679-7688
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Acquired Cellular Resistance to Flavopiridol in a Human Colon Carcinoma Cell Line Involves Up-Regulation of the Telomerase Catalytic Subunit and Telomere Elongation. Sensitivity of Resistant Cells to Combination Treatment with a Telomerase Inhibitor.
C. M. Incles, C. M. Schultes, L. R. Kelland, and S. Neidle (2003)
Mol. Pharmacol. 64, 1101-1108
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Hiding at the ends of yeast chromosomes: telomeres, nucleases and checkpoint pathways.
D. Lydall (2003)
J. Cell Sci. 116, 4057-4065
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Competition between the Rad50 Complex and the Ku Heterodimer Reveals a Role for Exo1 in Processing Double-Strand Breaks but Not Telomeres.
K. Tomita, A. Matsuura, T. Caspari, A. M. Carr, Y. Akamatsu, H. Iwasaki, K.-i. Mizuno, K. Ohta, M. Uritani, T. Ushimaru, et al. (2003)
Mol. Cell. Biol. 23, 5186-5197
   Abstract »    Full Text »    PDF »
Sequence-specific Binding to Telomeric DNA by CEH-37, a Homeodomain Protein in the Nematode Caenorhabditis elegans.
S. H. Kim, S. B. Hwang, I. K. Chung, and J. Lee (2003)
J. Biol. Chem. 278, 28038-28044
   Abstract »    Full Text »    PDF »


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