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Control of a Genetic Regulatory Network by a Selector Gene
Kirsten A. Guss,*Craig E. Nelson,*Angela Hudson,Mary Ellen Kraus,Sean B. Carroll
The formation of many complex structures is controlled by a special
class of transcription factors encoded by selector genes.It is shown
that SCALLOPED, the DNA binding component of the selectorprotein
complex for the Drosophila wing field, binds to and directlyregulates the cis-regulatory elements of many individual targetgenes
within the genetic regulatory network controlling wing development.Furthermore, combinations of binding sites for SCALLOPED and
transcriptionaleffectors of signaling pathways are necessary and
sufficient tospecify wing-specific responses to different signaling
pathways.The obligate integration of selector and signaling protein
inputson cis-regulatory DNA may be a general mechanism by which
selectorproteins control extensive genetic regulatory networks duringdevelopment.
Howard Hughes Medical Institute and Laboratory of Molecular
Biology, University of Wisconsin, Madison, WI 53706, USA.
*
These authors contributed equally to this work.
To whom correspondence should be addressed. E-mail:
sbcarrol{at}facstaff.wisc.edu
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