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Science 4 May 2001:
Vol. 292. no. 5518, pp. 934 - 937
DOI: 10.1126/science.1060042
Prev | Table of Contents

Reports

Vital Involvement of a Natural Killer Cell Activation Receptor in Resistance to Viral Infection

Michael G. Brown,1*dagger Ayotunde O. Dokun,12* Jonathan W. Heusel,1 Hamish R. C. Smith,1 Diana L. Beckman,1 Erika A. Blattenberger,1 Chad E. Dubbelde,1 Laurie R. Stone,1 Anthony A. Scalzo,3 Wayne M. Yokoyama1ddagger

Natural killer (NK) cells are lymphocytes that can be distinguished from T and B cells through their involvement in innate immunity and their lack of rearranged antigen receptors. Although NK cells and their receptors were initially characterized in terms of tumor killing in vitro, we have determined that the NK cell activation receptor, Ly-49H, is critically involved in resistance to murine cytomegalovirus in vivo. Ly-49H requires an immunoreceptor tyrosine-based activation motif (ITAM)-containing transmembrane molecule for expression and signal transduction. Thus, NK cells use receptors functionally resembling ITAM-coupled T and B cell antigen receptors to provide vital innate host defense.

1 Howard Hughes Medical Institute, Rheumatology Division, Washington University School of Medicine, St. Louis, MO 63110, USA.
2 Immunobiology Graduate Program, Mount Sinai School of Medicine, New York, NY 10029, USA.
3 Department of Microbiology, University of Western Australia, Nedlands, Western Australia 6907, Australia.
*   These authors contributed equally to this work.

dagger    Present address: Division of Rheumatology and Immunology, University of Virginia Health Sciences Center, Box 800412, Charlottesville, VA 22908, USA.

ddagger    To whom correspondence should be addressed. E-mail: yokoyama{at}imgate.wustl.edu

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The Clearance of Hepatitis C Virus Infection in Chimpanzees May Not Necessarily Correlate with the Appearance of Acquired Immunity.
M. Thomson, M. Nascimbeni, M. B. Havert, M. Major, S. Gonzales, H. Alter, S. M. Feinstone, K. K. Murthy, B. Rehermann, and T. J. Liang (2002)
J. Virol. 77, 862-870
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Allelic Variation in the Ectodomain of the Inhibitory Ly-49G2 Receptor Alters Its Specificity for Allogeneic and Xenogeneic Ligands.
E. T. Silver, K. J. Lavender, D.-E. Gong, B. Hazes, and K. P. Kane (2002)
J. Immunol. 169, 4752-4760
   Abstract »    Full Text »    PDF »
Hydrodynamic injection of viral DNA: A mouse model of acute hepatitis B virus infection.
P. L. Yang, A. Althage, J. Chung, and F. V. Chisari (2002)
PNAS 99, 13825-13830
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Susceptibility to malaria as a complex trait: big pressure from a tiny creature.
A. Fortin, M.M. Stevenson, and P. Gros (2002)
Hum. Mol. Genet. 11, 2469-2478
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Cutting Edge: Susceptibility to Psoriatic Arthritis: Influence of Activating Killer Ig-Like Receptor Genes in the Absence of Specific HLA-C Alleles.
M. P. Martin, G. Nelson, J.-H. Lee, F. Pellett, X. Gao, J. Wade, M. J. Wilson, J. Trowsdale, D. Gladman, and M. Carrington (2002)
J. Immunol. 169, 2818-2822
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NK Cell Activity During Human Cytomegalovirus Infection Is Dominated by US2-11-Mediated HLA Class I Down-Regulation.
C. S. Falk, M. Mach, D. J. Schendel, E. H. Weiss, I. Hilgert, and G. Hahn (2002)
J. Immunol. 169, 3257-3266
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Aberrant DAP12 Signaling in the 129 Strain of Mice: Implications for the Analysis of Gene-Targeted Mice.
D. W. McVicar, R. Winkler-Pickett, L. S. Taylor, A. Makrigiannis, M. Bennett, S. K. Anderson, and J. R. Ortaldo (2002)
J. Immunol. 169, 1721-1728
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Ly-49s3 Is a Promiscuous Activating Rat NK Cell Receptor for Nonclassical MHC Class I-Encoded Target Ligands.
C. Naper, S. Hayashi, L. Kveberg, E. C. Niemi, L. L. Lanier, J. T. Vaage, and J. C. Ryan (2002)
J. Immunol. 169, 22-30
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Recognition of a virus-encoded ligand by a natural killer cell activation receptor.
H. R. C. Smith, J. W. Heusel, I. K. Mehta, S. Kim, B. G. Dorner, O. V. Naidenko, K. Iizuka, H. Furukawa, D. L. Beckman, J. T. Pingel, et al. (2002)
PNAS 99, 8826-8831
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From the Cover: UL40-mediated NK evasion during productive infection with human cytomegalovirus.
E. C. Y. Wang, B. McSharry, C. Retiere, P. Tomasec, S. Williams, L. K. Borysiewicz, V. M. Braud, and G. W. G. Wilkinson (2002)
PNAS 99, 7570-7575
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Interferon-{alpha} as an immunotherapeutic protein.
D. L. Brassard, M. J. Grace, and R. W. Bordens (2002)
J. Leukoc. Biol. 71, 565-581
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Cutting Edge: Inhibitory Functions of the Killer Cell Lectin-Like Receptor G1 Molecule During the Activation of Mouse NK Cells.
S. H. Robbins, K. B. Nguyen, N. Takahashi, T. Mikayama, C. A. Biron, and L. Brossay (2002)
J. Immunol. 168, 2585-2589
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