Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.
Active Motif, Inc.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 4 May 2001:
Vol. 292. no. 5518, pp. 934 - 937
DOI: 10.1126/science.1060042
Prev | Table of Contents

Reports

Vital Involvement of a Natural Killer Cell Activation Receptor in Resistance to Viral Infection

Michael G. Brown,1*dagger Ayotunde O. Dokun,12* Jonathan W. Heusel,1 Hamish R. C. Smith,1 Diana L. Beckman,1 Erika A. Blattenberger,1 Chad E. Dubbelde,1 Laurie R. Stone,1 Anthony A. Scalzo,3 Wayne M. Yokoyama1ddagger

Natural killer (NK) cells are lymphocytes that can be distinguished from T and B cells through their involvement in innate immunity and their lack of rearranged antigen receptors. Although NK cells and their receptors were initially characterized in terms of tumor killing in vitro, we have determined that the NK cell activation receptor, Ly-49H, is critically involved in resistance to murine cytomegalovirus in vivo. Ly-49H requires an immunoreceptor tyrosine-based activation motif (ITAM)-containing transmembrane molecule for expression and signal transduction. Thus, NK cells use receptors functionally resembling ITAM-coupled T and B cell antigen receptors to provide vital innate host defense.

1 Howard Hughes Medical Institute, Rheumatology Division, Washington University School of Medicine, St. Louis, MO 63110, USA.
2 Immunobiology Graduate Program, Mount Sinai School of Medicine, New York, NY 10029, USA.
3 Department of Microbiology, University of Western Australia, Nedlands, Western Australia 6907, Australia.
*   These authors contributed equally to this work.

dagger    Present address: Division of Rheumatology and Immunology, University of Virginia Health Sciences Center, Box 800412, Charlottesville, VA 22908, USA.

ddagger    To whom correspondence should be addressed. E-mail: yokoyama{at}imgate.wustl.edu

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Continuous engagement of a self-specific activation receptor induces NK cell tolerance.
S. K. Tripathy, P. A. Keyel, L. Yang, J. T. Pingel, T. P. Cheng, A. Schneeberger, and W. M. Yokoyama (2008)
J. Exp. Med. 205, 1829-1841
   Abstract »    Full Text »    PDF »
Tolerance of NK cells encountering their viral ligand during development.
J. C. Sun and L. L. Lanier (2008)
J. Exp. Med. 205, 1819-1828
   Abstract »    Full Text »    PDF »
Characterization of Murine Cytomegalovirus m157 from Infected Cells and Identification of Critical Residues Mediating Recognition by the NK Cell Receptor Ly49H.
A. H. Davis, N. V. Guseva, B. L. Ball, and J. W. Heusel (2008)
J. Immunol. 181, 265-275
   Abstract »    Full Text »    PDF »
Ly49H+ NK Cells Migrate to and Protect Splenic White Pulp Stroma from Murine Cytomegalovirus Infection.
V. Bekiaris, O. Timoshenko, T. Z. Hou, K. Toellner, S. Shakib, F. Gaspal, F. M. McConnell, S. M. Parnell, D. Withers, C. D. Buckley, et al. (2008)
J. Immunol. 180, 6768-6776
   Abstract »    Full Text »    PDF »
NK Cells Expressing a Progesterone Receptor Are Susceptible to Progesterone-Induced Apoptosis.
L. Arruvito, S. Giulianelli, A. C. Flores, N. Paladino, M. Barboza, C. Lanari, and L. Fainboim (2008)
J. Immunol. 180, 5746-5753
   Abstract »    Full Text »    PDF »
Primary naive and interleukin-2-activated natural killer cells do not support efficient ectromelia virus replication.
A. K. Parker, W. M. Yokoyama, J. A. Corbett, N. Chen, and R. M. L. Buller (2008)
J. Gen. Virol. 89, 751-759
   Abstract »    Full Text »    PDF »
Regulation of the NK Cell Alloreactivity to Bone Marrow Cells by the Combination of the Host NK Gene Complex and MHC Haplotypes.
K. Iizuka, A. A. Scalzo, H. Xian, and W. M. Yokoyama (2008)
J. Immunol. 180, 3260-3267
   Abstract »    Full Text »    PDF »
Direct Action of Type I IFN on NK Cells Is Required for Their Activation in Response to Vaccinia Viral Infection In Vivo.
J. Martinez, X. Huang, and Y. Yang (2008)
J. Immunol. 180, 1592-1597
   Abstract »    Full Text »    PDF »
TLR-dependent cross talk between human Kupffer cells and NK cells.
Z. Tu, A. Bozorgzadeh, R. H. Pierce, J. Kurtis, I. N. Crispe, and M. S. Orloff (2008)
J. Exp. Med. 205, 233-244
   Abstract »    Full Text »    PDF »
The impact of regulatory T cells on T-cell immunity following hematopoietic cell transplantation.
V. H. Nguyen, S. Shashidhar, D. S. Chang, L. Ho, N. Kambham, M. Bachmann, J. M. Brown, and R. S. Negrin (2008)
Blood 111, 945-953
   Abstract »    Full Text »    PDF »
Thymosin {alpha}1 activates the TLR9/MyD88/IRF7-dependent murine cytomegalovirus sensing for induction of anti-viral responses in vivo.
S. Bozza, R. Gaziano, P. Bonifazi, T. Zelante, L. Pitzurra, C. Montagnoli, S. Moretti, R. Castronari, P. Sinibaldi, G. Rasi, et al. (2007)
Int. Immunol. 19, 1261-1270
   Abstract »    Full Text »    PDF »
Natural Killer Cells and CD4+ T-Cells Modulate Collateral Artery Development.
V. van Weel, R.E.M. Toes, L. Seghers, M.M.L. Deckers, M.R. de Vries, P.H. Eilers, J. Sipkens, A. Schepers, D. Eefting, V.W.M. van Hinsbergh, et al. (2007)
Arterioscler. Thromb. Vasc. Biol. 27, 2310-2318
   Abstract »    Full Text »    PDF »
Protection from Lethal Infection by Adoptive Transfer of CD8 T Cells Genetically Engineered to Express Virus-Specific Innate Immune Receptor.
K. Iizuka, C. Nakajima, Y.-M. Iizuka, M. Takase, T. Kato, S. Noda, K. Tanaka, and O. Kanagawa (2007)
J. Immunol. 179, 1122-1128
   Abstract »    Full Text »    PDF »
Structural elucidation of the m157 mouse cytomegalovirus ligand for Ly49 natural killer cell receptors.
E. J. Adams, Z. S. Juo, R. T. Venook, M. J. Boulanger, H. Arase, L. L. Lanier, and K. C. Garcia (2007)
PNAS 104, 10128-10133
   Abstract »    Full Text »    PDF »
Jinx, an MCMV susceptibility phenotype caused by disruption of Unc13d: a mouse model of type 3 familial hemophagocytic lymphohistiocytosis.
K. Crozat, K. Hoebe, S. Ugolini, N. A. Hong, E. Janssen, S. Rutschmann, S. Mudd, S. Sovath, E. Vivier, and B. Beutler (2007)
J. Exp. Med. 204, 853-863
   Abstract »    Full Text »    PDF »
Increased Expression of Leukocyte Ig-Like Receptor-1 and Activating Role of UL18 in the Response to Cytomegalovirus Infection.
C. S. Wagner, G. C. Riise, T. Bergstrom, K. Karre, E. Carbone, and L. Berg (2007)
J. Immunol. 178, 3536-3543
   Abstract »    Full Text »    PDF »
Extensive sequence variation exists among isolates of murine cytomegalovirus within members of the m02 family of genes.
A. J. Corbett, C. A. Forbes, D. Moro, and A. A. Scalzo (2007)
J. Gen. Virol. 88, 758-769
   Abstract »    Full Text »    PDF »
CXCR3-Dependent Recruitment of Antigen-Specific T Lymphocytes to the Liver during Murine Cytomegalovirus Infection.
K. L. Hokeness, E. S. Deweerd, M. W. Munks, C. A. Lewis, R. P. Gladue, and T. P. Salazar-Mather (2007)
J. Virol. 81, 1241-1250
   Abstract »    Full Text »    PDF »
Deficient Major Histocompatibility Complex-Linked Innate Murine Cytomegalovirus Immunity in MA/My.L-H2b Mice and Viral Downregulation of H-2k Class I Proteins.
X. Xie, A. Dighe, P. Clark, P. Sabastian, S. Buss, and M. G. Brown (2007)
J. Virol. 81, 229-236
   Abstract »    Full Text »    PDF »
Critical Residues at the Ly49 Natural Killer Receptor's Homodimer Interface Determine Functional Recognition of m157, a Mouse Cytomegalovirus MHC Class I-Like Protein.
A. Kielczewska, H.-S. Kim, L. L. Lanier, N. Dimasi, and S. M. Vidal (2007)
J. Immunol. 178, 369-377
   Abstract »    Full Text »    PDF »
Familial NK Cell Deficiency Associated with Impaired IL-2- and IL-15-Dependent Survival of Lymphocytes.
C. Eidenschenk, E. Jouanguy, A. Alcais, J.-J. Mention, B. Pasquier, I. M. Fleckenstein, A. Puel, L. Gineau, J.-C. Carel, E. Vivier, et al. (2006)
J. Immunol. 177, 8835-8843
   Abstract »    Full Text »    PDF »
Pentraxin 3 protects from MCMV infection and reactivation through TLR sensing pathways leading to IRF3 activation.
S. Bozza, F. Bistoni, R. Gaziano, L. Pitzurra, T. Zelante, P. Bonifazi, K. Perruccio, S. Bellocchio, M. Neri, A. M. Iorio, et al. (2006)
Blood 108, 3387-3396
   Abstract »    Full Text »    PDF »
The First Molecular Basis of the "Missing Self" Hypothesis.
F. Borrego (2006)
J. Immunol. 177, 5759-5760
   Full Text »    PDF »
Characterization of Immunodeficiency in a Patient With Growth Hormone Insensitivity Secondary to a Novel STAT5b Gene Mutation.
A. Bernasconi, R. Marino, A. Ribas, J. Rossi, M. Ciaccio, M. Oleastro, A. Ornani, R. Paz, M. A. Rivarola, M. Zelazko, et al. (2006)
Pediatrics 118, e1584-e1592
   Abstract »    Full Text »    PDF »
DAP12 Signaling Directly Augments Proproliferative Cytokine Stimulation of NK Cells during Viral Infections.
A. R. French, H. Sjolin, S. Kim, R. Koka, L. Yang, D. A. Young, C. Cerboni, E. Tomasello, A. Ma, E. Vivier, et al. (2006)
J. Immunol. 177, 4981-4990
   Abstract »    Full Text »    PDF »
Distinct indirect pathways govern human NK-cell activation by TLR-7 and TLR-8 agonists.
K. S. Gorski, E. L. Waller, J. Bjornton-Severson, J. A. Hanten, C. L. Riter, W. C. Kieper, K. B. Gorden, J. S. Miller, J. P. Vasilakos, M. A. Tomai, et al. (2006)
Int. Immunol. 18, 1115-1126
   Abstract »    Full Text »    PDF »
Role for TLR2 in NK Cell-Mediated Control of Murine Cytomegalovirus In Vivo.
E. Szomolanyi-Tsuda, X. Liang, R. M. Welsh, E. A. Kurt-Jones, and R. W. Finberg (2006)
J. Virol. 80, 4286-4291
   Abstract »    Full Text »    PDF »
Cmv4, a New Locus Linked to the NK Cell Gene Complex, Controls Innate Resistance to Cytomegalovirus in Wild-Derived Mice.
S. G. Adam, A. Caraux, N. Fodil-Cornu, J. C. Loredo-Osti, S. Lesjean-Pottier, J. Jaubert, I. Bubic, S. Jonjic, J.-L. Guenet, S. M. Vidal, et al. (2006)
J. Immunol. 176, 5478-5485
   Abstract »    Full Text »    PDF »
Expression of m157, a Murine Cytomegalovirus-Encoded Putative Major Histocompatibility Class I (MHC-I)-Like Protein, Is Independent of Viral Regulation of Host MHC-I.
S. K. Tripathy, H. R. C. Smith, E. A. Holroyd, J. T. Pingel, and W. M. Yokoyama (2006)
J. Virol. 80, 545-550
   Abstract »    Full Text »    PDF »
MyD88-Dependent and -Independent Murine Cytomegalovirus Sensing for IFN-{alpha} Release and Initiation of Immune Responses In Vivo.
T. Delale, A. Paquin, C. Asselin-Paturel, M. Dalod, G. Brizard, E. E. M. Bates, P. Kastner, S. Chan, S. Akira, A. Vicari, et al. (2005)
J. Immunol. 175, 6723-6732
   Abstract »    Full Text »    PDF »
Requisite H2k Role in NK Cell-Mediated Resistance in Acute Murine Cytomegalovirus-Infected MA/My Mice.
A. Dighe, M. Rodriguez, P. Sabastian, X. Xie, M. McVoy, and M. G. Brown (2005)
J. Immunol. 175, 6820-6828
   Abstract »    Full Text »    PDF »
Natural-killer cells and dendritic cells: "l'union fait la force".
T. Walzer, M. Dalod, S. H. Robbins, L. Zitvogel, and E. Vivier (2005)
Blood 106, 2252-2258
   Abstract »    Full Text »    PDF »
Recognition of peptide-MHC class I complexes by activating killer immunoglobulin-like receptors.
C. A. Stewart, F. Laugier-Anfossi, F. Vely, X. Saulquin, J. Riedmuller, A. Tisserant, L. Gauthier, F. Romagne, G. Ferracci, F. A. Arosa, et al. (2005)
PNAS 102, 13224-13229
   Abstract »    Full Text »    PDF »
Identification of Quantitative Trait Loci for Susceptibility to Mouse Adenovirus Type 1.
A. R. Welton, E. J. Chesler, C. Sturkie, A. U. Jackson, G. N. Hirsch, and K. R. Spindler (2005)
J. Virol. 79, 11517-11522
   Abstract »    Full Text »    PDF »
TLR7/8-Mediated Activation of Human NK Cells Results in Accessory Cell-Dependent IFN-{gamma} Production.
O. M. Hart, V. Athie-Morales, G. M. O'Connor, and C. M. Gardiner (2005)
J. Immunol. 175, 1636-1642
   Abstract »    Full Text »    PDF »
A Lymphotoxin-IFN-{beta} Axis Essential for Lymphocyte Survival Revealed during Cytomegalovirus Infection.
T. A. Banks, S. Rickert, C. A. Benedict, L. Ma, M. Ko, J. Meier, W. Ha, K. Schneider, S. W. Granger, O. Turovskaya, et al. (2005)
J. Immunol. 174, 7217-7225
   Abstract »    Full Text »    PDF »
A requirement for CD45 distinguishes Ly49D-mediated cytokine and chemokine production from killing in primary natural killer cells.
N. D. Huntington, Y. Xu, S. L. Nutt, and D. M. Tarlinton (2005)
J. Exp. Med. 201, 1421-1433
   Abstract »    Full Text »    PDF »
NK cell activation through the NKG2D ligand MULT-1 is selectively prevented by the glycoprotein encoded by mouse cytomegalovirus gene m145.
A. Krmpotic, M. Hasan, A. Loewendorf, T. Saulig, A. Halenius, T. Lenac, B. Polic, I. Bubic, A. Kriegeskorte, E. Pernjak-Pugel, et al. (2005)
J. Exp. Med. 201, 211-220
   Abstract »    Full Text »    PDF »
Natural Killer Cells Utilize both Perforin and Gamma Interferon To Regulate Murine Cytomegalovirus Infection in the Spleen and Liver.
J. Loh, D. T. Chu, A. K. O'Guin, W. M. Yokoyama, and H. W. Virgin IV (2005)
J. Virol. 79, 661-667
   Abstract »    Full Text »    PDF »
Mature myeloid dendritic cell subsets have distinct roles for activation and viability of circulating human natural killer cells.
C. Munz, T. Dao, G. Ferlazzo, M. A. de Cos, K. Goodman, and J. W. Young (2005)
Blood 105, 266-273
   Abstract »    Full Text »    PDF »
Recruitment of Uterine NK Cells: Induction of CXC Chemokine Ligands 10 and 11 in Human Endometrium by Estradiol and Progesterone.
C. L. Sentman, S. K. Meadows, C. R. Wira, and M. Eriksson (2004)
J. Immunol. 173, 6760-6766
   Abstract »    Full Text »    PDF »
Distinct roles of IL-12 and IL-15 in human natural killer cell activation by dendritic cells from secondary lymphoid organs.
G. Ferlazzo, M. Pack, D. Thomas, C. Paludan, D. Schmid, T. Strowig, G. Bougras, W. A. Muller, L. Moretta, and C. Munz (2004)
PNAS 101, 16606-16611
   Abstract »    Full Text »    PDF »
Cmv1-Independent Antiviral Role of NK Cells Revealed in Murine Cytomegalovirus-Infected New Zealand White Mice.
M. Rodriguez, P. Sabastian, P. Clark, and M. G. Brown (2004)
J. Immunol. 173, 6312-6318
   Abstract »    Full Text »    PDF »
NK cell activation by dendritic cells (DCs) requires the formation of a synapse leading to IL-12 polarization in DCs.
C. Borg, A. Jalil, D. Laderach, K. Maruyama, H. Wakasugi, S. Charrier, B. Ryffel, A. Cambi, C. Figdor, W. Vainchenker, et al. (2004)
Blood 104, 3267-3275
   Abstract »    Full Text »    PDF »
Re-Evaluating Natural Resistance to Herpes Simplex Virus Type 1.
W. P. Halford, J. W. Balliet, and B. M. Gebhardt (2004)
J. Virol. 78, 10086-10095
   Abstract »    Full Text »    PDF »
Role of Natural Killer Cells in Innate Protection against Lethal Ebola Virus Infection.
K. L. Warfield, J. G. Perkins, D. L. Swenson, E. M. Deal, C. M. Bosio, M. J. Aman, W. M. Yokoyama, H. A. Young, and S. Bavari (2004)
J. Exp. Med. 200, 169-179
   Abstract »    Full Text »    PDF »
Gain of Virulence Caused by Loss of a Gene in Murine Cytomegalovirus.
I. Bubic, M. Wagner, A. Krmpotic, T. Saulig, S. Kim, W. M. Yokoyama, S. Jonjic, and U. H. Koszinowski (2004)
J. Virol. 78, 7536-7544
   Abstract »    Full Text »    PDF »
NK Cells Stimulate Proliferation of T and NK Cells through 2B4/CD48 Interactions.
E. Assarsson, T. Kambayashi, J. D. Schatzle, S. O. Cramer, A. von Bonin, P. E. Jensen, H.-G. Ljunggren, and B. J. Chambers (2004)
J. Immunol. 173, 174-180
   Abstract »    Full Text »    PDF »
Expansion and Contraction of the NK Cell Compartment in Response to Murine Cytomegalovirus Infection.
S. H. Robbins, M. S. Tessmer, T. Mikayama, and L. Brossay (2004)
J. Immunol. 173, 259-266
   Abstract »    Full Text »    PDF »
Infection of mature monocyte-derived dendritic cells with human cytomegalovirus inhibits stimulation of T-cell proliferation via the release of soluble CD83.
B. Senechal, A. M. Boruchov, J. L. Reagan, D. N. J. Hart, and J. W. Young (2004)
Blood 103, 4207-4215
   Abstract »    Full Text »    PDF »
Toll-like receptors 9 and 3 as essential components of innate immune defense against mouse cytomegalovirus infection.
K. Tabeta, P. Georgel, E. Janssen, X. Du, K. Hoebe, K. Crozat, S. Mudd, L. Shamel, S. Sovath, J. Goode, et al. (2004)
PNAS 101, 3516-3521
   Abstract »    Full Text »    PDF »
Coordinate Expression of Cytokines and Chemokines by NK Cells during Murine Cytomegalovirus Infection.
B. G. Dorner, H. R.C. Smith, A. R. French, S. Kim, J. Poursine-Laurent, D. L. Beckman, J. T. Pingel, R. A. Kroczek, and W. M. Yokoyama (2004)
J. Immunol. 172, 3119-3131
   Abstract »    Full Text »    PDF »
NK Cell Compartments and Their Activation by Dendritic Cells.
G. Ferlazzo and C. Munz (2004)
J. Immunol. 172, 1333-1339
   Full Text »    PDF »
Independent Control of Ly49g Alleles: Implications for NK Cell Repertoire Selection and Tumor Cell Killing.
A. P. Makrigiannis, E. Rousselle, and S. K. Anderson (2004)
J. Immunol. 172, 1414-1425
   Abstract »    Full Text »    PDF »
A Novel Developmental and Immunodeficiency Syndrome Associated With Intrauterine Growth Retardation and a Lack of Natural Killer Cells.
F. Bernard, C. Picard, V. Cormier-Daire, C. Eidenschenk, G. Pinto, J.-C. Bustamante, E. Jouanguy, D. Teillac-Hamel, V. Colomb, I. Funck-Brentano, et al. (2004)
Pediatrics 113, 136-141
   Abstract »    Full Text »    PDF »
Two-signal requirement for activation and effector function of natural killer cell response to allogeneic tumor cells.
J.-X. Gao, X. Liu, J. Wen, M. A. Caligiuri, I. Stroynowski, P. Zheng, and Y. Liu (2003)
Blood 102, 4456-4463
   Abstract »    Full Text »    PDF »
Murine cytomegalovirus m157 mutation and variation leads to immune evasion of natural killer cells.
V. Voigt, C. A. Forbes, J. N. Tonkin, M. A. Degli-Esposti, H. R. C. Smith, W. M. Yokoyama, and A. A. Scalzo (2003)
PNAS 100, 13483-13488
   Abstract »    Full Text »    PDF »
A Locus on Mouse Chromosome 6 That Determines Resistance to Herpes Simplex Virus Also Influences Reactivation, While an Unlinked Locus Augments Resistance of Female Mice.
P. Lundberg, P. Welander, H. Openshaw, C. Nalbandian, C. Edwards, L. Moldawer, and E. Cantin (2003)
J. Virol. 77, 11661-11673
   Abstract »    Full Text »    PDF »
Activating and Inhibitory Ly49 Receptors Modulate NK Cell Chemotaxis to CXC Chemokine Ligand (CXCL) 10 and CXCL12.
M. Inngjerdingen, B. Rolstad, and J. C. Ryan (2003)
J. Immunol. 171, 2889-2895
   Abstract »    Full Text »    PDF »
Upregulation of Major Histocompatibility Complex Class I on Liver Cells by Hepatitis C Virus Core Protein via p53 and TAP1 Impairs Natural Killer Cell Cytotoxicity.
K. Herzer, C. S. Falk, J. Encke, S. T. Eichhorst, A. Ulsenheimer, B. Seliger, and P. H. Krammer (2003)
J. Virol. 77, 8299-8309
   Abstract »    Full Text »    PDF »
Common lymphoid progenitors rapidly engraft and protect against lethal murine cytomegalovirus infection after hematopoietic stem cell transplantation.
C. Arber, A. BitMansour, T. E. Sparer, J. P. Higgins, E. S. Mocarski, I. L. Weissman, J. A. Shizuru, and J. M. Y. Brown (2003)
Blood 102, 421-428
   Abstract »    Full Text »    PDF »
NKG2D-mediated Natural Killer Cell Protection Against Cytomegalovirus Is Impaired by Viral gp40 Modulation of Retinoic Acid Early Inducible 1 Gene Molecules.
M. Lodoen, K. Ogasawara, J. A. Hamerman, H. Arase, J. P. Houchins, E. S. Mocarski, and L. L. Lanier (2003)
J. Exp. Med. 197, 1245-1253
   Abstract »    Full Text »    PDF »
Transgenic Expression of the Activating Natural Killer Receptor Ly49H Confers Resistance to Cytomegalovirus in Genetically Susceptible Mice.
S.-H. Lee, A. Zafer, Y. de Repentigny, R. Kothary, M. L. Tremblay, P. Gros, P. Duplay, J. R. Webb, and S. M. Vidal (2003)
J. Exp. Med. 197, 515-526
   Abstract »    Full Text »    PDF »
Activation of Natural Killer (NK) T Cells during Murine Cytomegalovirus Infection Enhances the Antiviral Response Mediated by NK Cells.
S. L. H. van Dommelen, H. A. Tabarias, M. J. Smyth, and M. A. Degli-Esposti (2003)
J. Virol. 77, 1877-1884
   Abstract »    Full Text »    PDF »
The Clearance of Hepatitis C Virus Infection in Chimpanzees May Not Necessarily Correlate with the Appearance of Acquired Immunity.
M. Thomson, M. Nascimbeni, M. B. Havert, M. Major, S. Gonzales, H. Alter, S. M. Feinstone, K. K. Murthy, B. Rehermann, and T. J. Liang (2002)
J. Virol. 77, 862-870
   Abstract »    Full Text »    PDF »
Allelic Variation in the Ectodomain of the Inhibitory Ly-49G2 Receptor Alters Its Specificity for Allogeneic and Xenogeneic Ligands.
E. T. Silver, K. J. Lavender, D.-E. Gong, B. Hazes, and K. P. Kane (2002)
J. Immunol. 169, 4752-4760
   Abstract »    Full Text »    PDF »
Hydrodynamic injection of viral DNA: A mouse model of acute hepatitis B virus infection.
P. L. Yang, A. Althage, J. Chung, and F. V. Chisari (2002)
PNAS 99, 13825-13830
   Abstract »    Full Text »    PDF »
Susceptibility to malaria as a complex trait: big pressure from a tiny creature.
A. Fortin, M.M. Stevenson, and P. Gros (2002)
Hum. Mol. Genet. 11, 2469-2478
   Abstract »    Full Text »    PDF »
Cutting Edge: Susceptibility to Psoriatic Arthritis: Influence of Activating Killer Ig-Like Receptor Genes in the Absence of Specific HLA-C Alleles.
M. P. Martin, G. Nelson, J.-H. Lee, F. Pellett, X. Gao, J. Wade, M. J. Wilson, J. Trowsdale, D. Gladman, and M. Carrington (2002)
J. Immunol. 169, 2818-2822
   Abstract »    Full Text »    PDF »
NK Cell Activity During Human Cytomegalovirus Infection Is Dominated by US2-11-Mediated HLA Class I Down-Regulation.
C. S. Falk, M. Mach, D. J. Schendel, E. H. Weiss, I. Hilgert, and G. Hahn (2002)
J. Immunol. 169, 3257-3266
   Abstract »    Full Text »    PDF »
Aberrant DAP12 Signaling in the 129 Strain of Mice: Implications for the Analysis of Gene-Targeted Mice.
D. W. McVicar, R. Winkler-Pickett, L. S. Taylor, A. Makrigiannis, M. Bennett, S. K. Anderson, and J. R. Ortaldo (2002)
J. Immunol. 169, 1721-1728
   Abstract »    Full Text »    PDF »
Ly-49s3 Is a Promiscuous Activating Rat NK Cell Receptor for Nonclassical MHC Class I-Encoded Target Ligands.
C. Naper, S. Hayashi, L. Kveberg, E. C. Niemi, L. L. Lanier, J. T. Vaage, and J. C. Ryan (2002)
J. Immunol. 169, 22-30
   Abstract »    Full Text »    PDF »
Recognition of a virus-encoded ligand by a natural killer cell activation receptor.
H. R. C. Smith, J. W. Heusel, I. K. Mehta, S. Kim, B. G. Dorner, O. V. Naidenko, K. Iizuka, H. Furukawa, D. L. Beckman, J. T. Pingel, et al. (2002)
PNAS 99, 8826-8831
   Abstract »    Full Text »    PDF »
Cell-Mediated Immune Response in MDMA Users After Repeated Dose Administration: Studies in Controlled versus Noncontrolled Settings.
R. PACIFICI, P. ZUCCARO, M. FARRE, S. PICHINI, S. DI CARLO, P. N. ROSET, I. PALMI, J. ORTUNO, E. MENOYO, J. SEGURA, et al. (2002)
Ann. N.Y. Acad. Sci. 965, 421-433
   Abstract »    Full Text »    PDF »
From the Cover: UL40-mediated NK evasion during productive infection with human cytomegalovirus.
E. C. Y. Wang, B. McSharry, C. Retiere, P. Tomasec, S. Williams, L. K. Borysiewicz, V. M. Braud, and G. W. G. Wilkinson (2002)
PNAS 99, 7570-7575
   Abstract »    Full Text »    PDF »
Interferon-{alpha} as an immunotherapeutic protein.
D. L. Brassard, M. J. Grace, and R. W. Bordens (2002)
J. Leukoc. Biol. 71, 565-581
   Abstract »    Full Text »    PDF »
Cutting Edge: Inhibitory Functions of the Killer Cell Lectin-Like Receptor G1 Molecule During the Activation of Mouse NK Cells.
S. H. Robbins, K. B. Nguyen, N. Takahashi, T. Mikayama, C. A. Biron, and L. Brossay (2002)
J. Immunol. 168, 2585-2589
   Abstract »    Full Text »    PDF »
Dendritic and Natural Killer Cells Cooperate in the Control/Switch of Innate Immunity.
L. Zitvogel (2002)
J. Exp. Med. 195, F9-F14
   Full Text »    PDF »
Analysis of In Situ NK Cell Responses During Viral Infection.
A. O. Dokun, D. T. Chu, L. Yang, A. S. Bendelac, and W. M. Yokoyama (2001)
J. Immunol. 167, 5286-5293
   Abstract »    Full Text »    PDF »
Pivotal Role of KARAP/DAP12 Adaptor Molecule in the Natural Killer Cell-mediated Resistance to Murine Cytomegalovirus Infection.
H. Sjolin, E. Tomasello, M. Mousavi-Jazi, A. Bartolazzi, K. Karre, E. Vivier, and C. Cerboni (2002)
J. Exp. Med. 195, 825-834
   Abstract »    Full Text »    PDF »


ADVERTISEMENT
Click Me!