Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 6 April 2001:
Vol. 292. no. 5514, pp. 107 - 110
DOI: 10.1126/science.1057987
Prev | Table of Contents | Next

Reports

A Mutant Drosophila Insulin Receptor Homolog That Extends Life-Span and Impairs Neuroendocrine Function

M. Tatar,1* A. Kopelman,1 D. Epstein,1 M.-P. Tu,12 C.-M. Yin,2 R. S. Garofalo3

The Drosophila melanogaster gene insulin-like receptor (InR) is homologous to mammalian insulin receptors as well as to Caenorhabditis elegans daf-2, a signal transducer regulating worm dauer formation and adult longevity. We describe a heteroallelic, hypomorphic genotype of mutant InR, which yields dwarf females with up to an 85% extension of adult longevity and dwarf males with reduced late age-specific mortality. Treatment of the long-lived InR dwarfs with a juvenile hormone analog restores life expectancy toward that of wild-type controls. We conclude that juvenile hormone deficiency, which results from InR signal pathway mutation, is sufficient to extend life-span, and that in flies, insulin-like ligands nonautonomously mediate aging through retardation of growth or activation of specific endocrine tissue.

1 Brown University, Providence, RI 02912, USA.
2 University of Massachusetts, Amherst, MA 01003, USA.
3 Pfizer Global Research and Development, Groton, CT 06340, USA.
*   To whom correspondence should be addressed. E-mail: Marc_Tatar{at}Brown.edu

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Regulation of Fat Cell Mass by Insulin in Drosophila melanogaster.
J. R. DiAngelo and M. J. Birnbaum (2009)
Mol. Cell. Biol. 29, 6341-6352
   Abstract »    Full Text »    PDF »
The endosymbiont Wolbachia increases insulin/IGF-like signalling in Drosophila.
T. Ikeya, S. Broughton, N. Alic, R. Grandison, and L. Partridge (2009)
Proc R Soc B 276, 3799-3807
   Abstract »    Full Text »    PDF »
Drosophila FoxO Regulates Organism Size and Stress Resistance through an Adenylate Cyclase.
J. Mattila, A. Bremer, L. Ahonen, R. Kostiainen, and O. Puig (2009)
Mol. Cell. Biol. 29, 5357-5365
   Abstract »    Full Text »    PDF »
Target of Rapamycin (TOR) Mediates the Transduction of Nutritional Signals into Juvenile Hormone Production.
J. L. Maestro, J. Cobo, and X. Belles (2009)
J. Biol. Chem. 284, 5506-5513
   Abstract »    Full Text »    PDF »
Immunity in a variable world.
B. P Lazzaro and T. J Little (2009)
Phil Trans R Soc B 364, 15-26
   Abstract »    Full Text »    PDF »
How to Live Long and Prosper: Autophagy, Mitochondria, and Aging.
W.-L. Yen and D. J. Klionsky (2008)
Physiology 23, 248-262
   Abstract »    Full Text »    PDF »
SHC-1/p52Shc targets the insulin/IGF-1 and JNK signaling pathways to modulate life span and stress response in C. elegans.
E. Neumann-Haefelin, W. Qi, E. Finkbeiner, G. Walz, R. Baumeister, and M. Hertweck (2008)
Genes & Dev. 22, 2721-2735
   Abstract »    Full Text »    PDF »
A potent dauer pheromone component in Caenorhabditis elegans that acts synergistically with other components.
R. A. Butcher, J. R. Ragains, E. Kim, and J. Clardy (2008)
PNAS 105, 14288-14292
   Abstract »    Full Text »    PDF »
A small-molecule compound identified through a cell-based screening inhibits JAK/STAT pathway signaling in human cancer cells.
B. H. Kim, C.-H. Yin, Q. Guo, E. A. Bach, H. Lee, C. Sandoval, S. Jayabose, A. Ulaczyk-Lesanko, D. G. Hall, and G.-H. Baeg (2008)
Mol. Cancer Ther. 7, 2672-2680
   Abstract »    Full Text »    PDF »
C. elegans dauer formation and the molecular basis of plasticity.
N. Fielenbach and A. Antebi (2008)
Genes & Dev. 22, 2149-2165
   Abstract »    Full Text »    PDF »
Evidence that the gene encoding insulin degrading enzyme influences human lifespan.
M.-G. Hong, C. Reynolds, M. Gatz, B. Johansson, J. C. Palmer, H. F. Gu, K. Blennow, P. G. Kehoe, U. de Faire, N. L. Pedersen, et al. (2008)
Hum. Mol. Genet. 17, 2370-2378
   Abstract »    Full Text »    PDF »
Insulin signaling and FOXO regulate the overwintering diapause of the mosquito Culex pipiens.
C. Sim and D. L. Denlinger (2008)
PNAS 105, 6777-6781
   Abstract »    Full Text »    PDF »
Drosophila germ-line modulation of insulin signaling and lifespan.
T. Flatt, K.-J. Min, C. D'Alterio, E. Villa-Cuesta, J. Cumbers, R. Lehmann, D. L. Jones, and M. Tatar (2008)
PNAS 105, 6368-6373
   Abstract »    Full Text »    PDF »
Evidence for lifespan extension and delayed age-related biomarkers in insulin receptor substrate 1 null mice.
C. Selman, S. Lingard, A. I. Choudhury, R. L. Batterham, M. Claret, M. Clements, F. Ramadani, K. Okkenhaug, E. Schuster, E. Blanc, et al. (2008)
FASEB J 22, 807-818
   Abstract »    Full Text »    PDF »
Signaling networks in aging.
E. L. Greer and A. Brunet (2008)
J. Cell Sci. 121, 407-412
   Full Text »    PDF »
Clustering of Genetically Defined Allele Classes in the Caenorhabditis elegans DAF-2 Insulin/IGF-1 Receptor.
D. S. Patel, A. Garza-Garcia, M. Nanji, J. J. McElwee, D. Ackerman, P. C. Driscoll, and D. Gems (2008)
Genetics 178, 931-946
   Abstract »    Full Text »    PDF »
Frequency of the G/G Genotype of Resistin Single Nucleotide Polymorphism at 420 Appears to Be Increased in Younger-Onset Type 2 Diabetes.
M. Ochi, H. Osawa, Y. Hirota, K. Hara, Y. Tabara, Y. Tokuyama, I. Shimizu, A. Kanatsuka, Y. Fujii, J. Ohashi, et al. (2007)
Diabetes 56, 2834-2838
   Abstract »    Full Text »    PDF »
Life and Death: Metabolic Rate, Membrane Composition, and Life Span of Animals.
A. J. Hulbert, R. Pamplona, R. Buffenstein, and W. A. Buttemer (2007)
Physiol Rev 87, 1175-1213
   Abstract »    Full Text »    PDF »
Expression of dominant-negative Dmp53 in the adult fly brain inhibits insulin signaling.
J. H. Bauer, C. Chang, S. N. S. Morris, S. Hozier, S. Andersen, J. S. Waitzman, and S. L. Helfand (2007)
PNAS 104, 13355-13360
   Abstract »    Full Text »    PDF »
A Drosophila ortholog of the human cylindromatosis tumor suppressor gene regulates triglyceride content and antibacterial defense.
T. Tsichritzis, P. C. Gaentzsch, S. Kosmidis, A. E. Brown, E. M. Skoulakis, P. Ligoxygakis, and G. Mosialos (2007)
Development 134, 2605-2614
   Abstract »    Full Text »    PDF »
Vitellogenin, juvenile hormone, insulin signaling, and queen honey bee longevity.
M. Corona, R. A. Velarde, S. Remolina, A. Moran-Lauter, Y. Wang, K. A. Hughes, and G. E. Robinson (2007)
PNAS 104, 7128-7133
   Abstract »    Full Text »    PDF »
Regulation of feeding behaviour and locomotor activity by takeout in Drosophila.
N. Meunier, Y. H. Belgacem, and J.-R. Martin (2007)
J. Exp. Biol. 210, 1424-1434
   Abstract »    Full Text »    PDF »
Liver X Receptor Alpha Associates With Human Life Span.
S. P. Mooijaart, M. Kuningas, R. G. J. Westendorp, J. J. Houwing-Duistermaat, P. E. Slagboom, P. C. N. Rensen, and D. van Heemst (2007)
J. Gerontol. A Biol. Sci. Med. Sci. 62, 343-349
   Abstract »    Full Text »    PDF »
High-resolution dynamics of the transcriptional response to nutrition in Drosophila: a key role for dFOXO.
B. Gershman, O. Puig, L. Hang, R. M. Peitzsch, M. Tatar, and R. S. Garofalo (2007)
Physiol Genomics 29, 24-34
   Abstract »    Full Text »    PDF »
Inhibition of wild-type p66ShcA in mesangial cells prevents glycooxidant-dependent FOXO3a regulation and promotes the survival phenotype.
J. Chintapalli, S. Yang, D. Opawumi, S. R. Goyal, N. Shamsuddin, A. Malhotra, K. Reiss, and L. G. Meggs (2007)
Am J Physiol Renal Physiol 292, F523-F530
   Abstract »    Full Text »    PDF »
IRES-mediated functional coupling of transcription and translation amplifies insulin receptor feedback.
M. T. Marr II, J. A. D'Alessio, O. Puig, and R. Tjian (2007)
Genes & Dev. 21, 175-183
   Abstract »    Full Text »    PDF »
An integrated view of oxidative stress in aging: basic mechanisms, functional effects, and pathological considerations.
K. C. Kregel and H. J. Zhang (2007)
Am J Physiol Regulatory Integrative Comp Physiol 292, R18-R36
   Abstract »    Full Text »    PDF »
Reduced growth of Drosophila neurofibromatosis 1 mutants reflects a non-cell-autonomous requirement for GTPase-Activating Protein activity in larval neurons.
J. A. Walker, A. V. Tchoudakova, P. T. McKenney, S. Brill, D. Wu, G. S. Cowley, I. K. Hariharan, and A. Bernards (2006)
Genes & Dev. 20, 3311-3323
   Abstract »    Full Text »    PDF »
Control of Metabolism and Growth Through Insulin-Like Peptides in Drosophila.
C. Geminard, N. Arquier, S. Layalle, M. Bourouis, M. Slaidina, R. Delanoue, M. Bjordal, M. Ohanna, M. Ma, J. Colombani, et al. (2006)
Diabetes 55, S5-S8
   Abstract »    Full Text »    PDF »
Natural variation in Drosophila melanogaster diapause due to the insulin-regulated PI3-kinase.
K. D. Williams, M. Busto, M. L. Suster, A. K.-C. So, Y. Ben-Shahar, S. J. Leevers, and M. B. Sokolowski (2006)
PNAS 103, 15911-15915
   Abstract »    Full Text »    PDF »
IFTA-2 is a conserved cilia protein involved in pathways regulating longevity and dauer formation in Caenorhabditis elegans.
J. C. Schafer, M. E. Winkelbauer, C. L. Williams, C. J. Haycraft, R. A. Desmond, and B. K. Yoder (2006)
J. Cell Sci. 119, 4088-4100
   Abstract »    Full Text »    PDF »
Having it all: historical energy intakes do not generate the anticipated trade-offs in fecundity.
S.L Johnston, T Grune, L.M Bell, S.J Murray, D.M Souter, S.S Erwin, J.M Yearsley, I.J Gordon, A.W Illius, I Kyriazakis, et al. (2006)
Proc R Soc B 273, 1369-1374
   Abstract »    Full Text »    PDF »
Purine and folate metabolism as a potential target of sex-specific nutrient allocation in Drosophila and its implication for lifespan-reproduction tradeoff.
M. Bauer, J. D. Katzenberger, A. C. Hamm, M. Bonaus, I. Zinke, J. Jaekel, and M. J. Pankratz (2006)
Physiol Genomics 25, 393-404
   Abstract »    Full Text »    PDF »
No extension of lifespan by ablation of germ line in Drosophila.
A. I Barnes, J. M Boone, J. Jacobson, L. Partridge, and T. Chapman (2006)
Proc R Soc B 273, 939-947
   Abstract »    Full Text »    PDF »
Effects of anticonvulsant drugs on life span..
K. Kornfeld and K. Evason (2006)
Arch Neurol 63, 491-496
   Abstract »    Full Text »    PDF »
Quantitative Trait Loci With Age-Specific Effects on Fecundity in Drosophila melanogaster.
J. Leips, P. Gilligan, and T. F. C. Mackay (2006)
Genetics 172, 1595-1605
   Abstract »    Full Text »    PDF »
Enigma, a mitochondrial protein affecting lifespan and oxidative stress response in Drosophila.
P. Mourikis, G. D. Hurlbut, and S. Artavanis-Tsakonas (2006)
PNAS 103, 1307-1312
   Abstract »    Full Text »    PDF »
Nuclear-Mitochondrial Epistasis and Drosophila Aging: Introgression of Drosophila simulans mtDNA Modifies Longevity in D. melanogaster Nuclear Backgrounds.
D. M. Rand, A. Fry, and L. Sheldahl (2006)
Genetics 172, 329-341
   Abstract »    Full Text »    PDF »
Tau Is Hyperphosphorylated in the Insulin-Like Growth Factor-I Null Brain.
C. M. Cheng, V. Tseng, J. Wang, D. Wang, L. Matyakhina, and C. A. Bondy (2005)
Endocrinology 146, 5086-5091
   Abstract »    Full Text »    PDF »
Developing a Research Agenda in Biogerontology: Basic Mechanisms.
H. R. Warner (2005)
Sci. Aging Knowl. Environ. 2005, pe33
   Abstract »    Full Text »
Suppression of Aging in Mice by the Hormone Klotho.
H. Kurosu, M. Yamamoto, J. D. Clark, J. V. Pastor, A. Nandi, P. Gurnani, O. P. McGuinness, H. Chikuda, M. Yamaguchi, H. Kawaguchi, et al. (2005)
Science 309, 1829-1833
   Abstract »    Full Text »    PDF »
Advancing age alters rapid and spontaneous refilling of caffeine-sensitive calcium stores in sympathetic superior cervical ganglion cells.
C. K. Vanterpool, W. J. Pearce, and J. N. Buchholz (2005)
J Appl Physiol 99, 963-971
   Abstract »    Full Text »    PDF »
Age-Specific Changes in Epistatic Effects on Mortality Rate in Drosophila melanogaster.
C. C. Spencer and D. E. L. Promislow (2005)
J. Hered. 96, 513-521
   Abstract »    Full Text »    PDF »
The Transcriptional Repressor dMnt Is a Regulator of Growth in Drosophila melanogaster.
L. W. M. Loo, J. Secombe, J. T. Little, L.-S. Carlos, C. Yost, P.-F. Cheng, E. M. Flynn, B. A. Edgar, and R. N. Eisenman (2005)
Mol. Cell. Biol. 25, 7078-7091
   Abstract »    Full Text »    PDF »
Direct Control of Germline Stem Cell Division and Cyst Growth by Neural Insulin in Drosophila.
L. LaFever and D. Drummond-Barbosa (2005)
Science 309, 1071-1073
   Abstract »    Full Text »    PDF »
Adult-Onset Growth Hormone and Insulin-Like Growth Factor I Deficiency Reduces Neoplastic Disease, Modifies Age-Related Pathology, and Increases Life Span.
W. E. Sonntag, C. S. Carter, Y. Ikeno, K. Ekenstedt, C. S. Carlson, R. F. Loeser, S. Chakrabarty, S. Lee, C. Bennett, R. Ingram, et al. (2005)
Endocrinology 146, 2920-2932
   Abstract »    Full Text »    PDF »
A systematic RNAi screen for longevity genes in C. elegans.
B. Hamilton, Y. Dong, M. Shindo, W. Liu, I. Odell, G. Ruvkun, and S. S. Lee (2005)
Genes & Dev. 19, 1544-1555
   Abstract »    Full Text »    PDF »
Fibroblast cell lines from young adult mice of long-lived mutant strains are resistant to multiple forms of stress.
A. B. Salmon, S. Murakami, A. Bartke, J. Kopchick, K. Yasumura, and R. A. Miller (2005)
Am J Physiol Endocrinol Metab 289, E23-E29
   Abstract »    Full Text »    PDF »
BIOLOGY, FRUIT FLIES, AND HUMANS: CAN EXTENDED LONGEVITY STRETCH FROM ONE TO THE OTHER?.
R. Arking (2005)
Gerontologist 45, 418-425
   Full Text »    PDF »
Body size, energy metabolism and lifespan.
J. R. Speakman (2005)
J. Exp. Biol. 208, 1717-1730
   Abstract »    Full Text »    PDF »
Insulin Signaling in the Central Nervous System: A Critical Role in Metabolic Homeostasis and Disease From C. elegans to Humans.
D. Porte Jr., D. G. Baskin, and M. W. Schwartz (2005)
Diabetes 54, 1264-1276
   Abstract »    Full Text »    PDF »
Analysis of long-lived C. elegans daf-2 mutants using serial analysis of gene expression.
J. Halaschek-Wiener, J. S. Khattra, S. McKay, A. Pouzyrev, J. M. Stott, G. S. Yang, R. A. Holt, S. J.M. Jones, M. A. Marra, A. R. Brooks-Wilson, et al. (2005)
Genome Res. 15, 603-615
   Abstract »    Full Text »    PDF »
Estrogen, Insulin, and Dietary Signals Cooperatively Regulate Longevity Signals to Enhance Resistance to Oxidative Stress in Mice.
T. Baba, T. Shimizu, Y.-i. Suzuki, M. Ogawara, K.-i. Isono, H. Koseki, H. Kurosawa, and T. Shirasawa (2005)
J. Biol. Chem. 280, 16417-16426
   Abstract »    Full Text »    PDF »
The Genetic Basis of Aging: An Evolutionary Biologist's Perspective.
D. N. Reznick (2005)
Sci. Aging Knowl. Environ. 2005, pe7
   Abstract »    Full Text »
Evidence for Down-Regulation of Phosphoinositide 3-Kinase/Akt/Mammalian Target of Rapamycin (PI3K/Akt/mTOR)-Dependent Translation Regulatory Signaling Pathways in Ames Dwarf Mice.
Z. D. Sharp and A. Bartke (2005)
J. Gerontol. A Biol. Sci. Med. Sci. 60, 293-300
   Abstract »    Full Text »    PDF »
Longer lifespan, altered metabolism, and stress resistance in Drosophila from ablation of cells making insulin-like ligands.
S. J. Broughton, M. D. W. Piper, T. Ikeya, T. M. Bass, J. Jacobson, Y. Driege, P. Martinez, E. Hafen, D. J. Withers, S. J. Leevers, et al. (2005)
PNAS 102, 3105-3110
   Abstract »    Full Text »    PDF »
Longevity and Metabolism in Drosophila melanogaster: Genetic Correlations Between Life Span and Age-Specific Metabolic Rate in Populations Artificially Selected for Long Life.
A. A. Khazaeli, W. Van Voorhies, and J. W. Curtsinger (2005)
Genetics 169, 231-242
   Abstract »    Full Text »    PDF »
Shared Transcriptional Signature in Caenorhabditis elegans Dauer Larvae and Long-lived daf-2 Mutants Implicates Detoxification System in Longevity Assurance.
J. J. McElwee, E. Schuster, E. Blanc, J. H. Thomas, and D. Gems (2004)
J. Biol. Chem. 279, 44533-44543
   Abstract »    Full Text »    PDF »
Decreased Lifespan in the Absence of Expression of the Mitochondrial Small Heat Shock Protein Hsp22 in Drosophila.
G. Morrow, S. Battistini, P. Zhang, and R. M. Tanguay (2004)
J. Biol. Chem. 279, 43382-43385
   Abstract »    Full Text »    PDF »
The effect of age on encounters between male crab spiders.
H. H. Hu and D. H. Morse (2004)
Behav. Ecol. 15, 883-888
   Abstract »    Full Text »    PDF »
An accelerated assay for the identification of lifespan-extending interventions in Drosophila melanogaster.
J. H. Bauer, S. Goupil, G. B. Garber, and S. L. Helfand (2004)
PNAS 101, 12980-12985
   Abstract »    Full Text »    PDF »
The TOR pathway interacts with the insulin signaling pathway to regulate C. elegans larval development, metabolism and life span.
K. Jia, D. Chen, and D. L. Riddle (2004)
Development 131, 3897-3906
   Abstract »    Full Text »    PDF »
Sex-Specific Effects of Interventions That Extend Fly Life Span.
J. M. S. Burger and D. E. L. Promislow (2004)
Sci. Aging Knowl. Environ. 2004, pe30
   Abstract »    Full Text »
The Future of Aging Interventions: The Human Life Span Is Not That Limited: The Effect of Multiple Longevity Phenotypes.
R. Arking, V. Novoseltsev, and J. Novoseltseva (2004)
J. Gerontol. A Biol. Sci. Med. Sci. 59, B697-B704
   Abstract »    Full Text »    PDF »
Inside Insulin Signaling, Communication Is Key to Long Life.
A. Antebi (2004)
Sci. Aging Knowl. Environ. 2004, pe25
   Abstract »    Full Text »
Mutations in Chemosensory Cilia Cause Resistance to Paraquat in Nematode Caenorhabditis elegans.
M. Fujii, Y. Matsumoto, N. Tanaka, K. Miki, T. Suzuki, N. Ishii, and D. Ayusawa (2004)
J. Biol. Chem. 279, 20277-20282
   Abstract »    Full Text »    PDF »
Temporal linkage between the phenotypic and genomic responses to caloric restriction.
J. M. Dhahbi, H.-J. Kim, P. L. Mote, R. J. Beaver, and S. R. Spindler (2004)
PNAS 101, 5524-5529
   Abstract »    Full Text »    PDF »
The Evolution of Programmed Death in a Spatially Structured Population.
J. M. J. Travis (2004)
J. Gerontol. A Biol. Sci. Med. Sci. 59, B301-B305
   Abstract »    Full Text »    PDF »
Cardiac Stem Cells Fail With Aging: A New Mechanism for the Age-Dependent Decline in Cardiac Function.
M. C. Capogrossi (2004)
Circ. Res. 94, 411-413
   Full Text »    PDF »
Modulation of mammalian life span by the short isoform of p53.
B. Maier, W. Gluba, B. Bernier, T. Turner, K. Mohammad, T. Guise, A. Sutherland, M. Thorner, and H. Scrable (2004)
Genes & Dev. 18, 306-319
   Abstract »    Full Text »    PDF »
Sex Differences in the Effect of Dietary Restriction on Life Span and Mortality Rates in Female and Male Drosophila Melanogaster.
T. Magwere, T. Chapman, and L. Partridge (2004)
J. Gerontol. A Biol. Sci. Med. Sci. 59, B3-9
   Abstract »    Full Text »    PDF »
Linkage between insulin and the free radical theory of aging.
D. Julian and C. Leeuwenburgh (2004)
Am J Physiol Regulatory Integrative Comp Physiol 286, R20-R21
   Full Text »    PDF »
Selected Contribution: Long-lived Drosophila melanogaster lines exhibit normal metabolic rates.
W. A. Van Voorhies, A. A. Khazaeli, and J. W. Curtsinger (2003)
J Appl Physiol 95, 2605-2613
   Abstract »    Full Text »
Linking Development and Aging.
B. J. Zwaan (2003)
Sci. Aging Knowl. Environ. 2003, pe32-32
   Abstract »    Full Text »
Genotype to Phenotype: Physiological Control of Trait Size and Scaling in Insects.
D. J. Emlen and C. E. Allen (2003)
Integr. Comp. Biol. 43, 617-634
   Abstract »    Full Text »    PDF »
PTEN: tumour suppressor, multifunctional growth regulator and more.
D. C.I. Goberdhan and C. Wilson (2003)
Hum. Mol. Genet. 12, R239-248
   Abstract »    Full Text »    PDF »
Reducing Integrins Improves the Quality of Fly Life.
C. N. Torgler and N. H. Brown (2003)
Sci. Aging Knowl. Environ. 2003, pe28-28
   Abstract »    Full Text »
Longevity Regulation in Saccharomyces cerevisiae: Linking Metabolism, Genome Stability, and Heterochromatin.
K. J. Bitterman, O. Medvedik, and D. A. Sinclair (2003)
Microbiol. Mol. Biol. Rev. 67, 376-399
   Abstract »    Full Text »    PDF »
Effects of Overexpression of Copper-Zinc and Manganese Superoxide Dismutases, Catalase, and Thioredoxin Reductase Genes on Longevity in Drosophila melanogaster.
W. C. Orr, R. J. Mockett, J. J. Benes, and R. S. Sohal (2003)
J. Biol. Chem. 278, 26418-26422
   Abstract »    Full Text »    PDF »
Science on the Fly.
I. Chen (2003)
Sci. Aging Knowl. Environ. 2003, nf13-13
   Abstract »    Full Text »
Longevity Genes: From Primitive Organisms to Humans.
R. N. Butler, S. N. Austad, N. Barzilai, A. Braun, S. Helfand, P. L. Larsen, A. M. McCormick, T. T. Perls, A. R. Shuldiner, R. L. Sprott, et al. (2003)
J. Gerontol. A Biol. Sci. Med. Sci. 58, B581-584
   Full Text »    PDF »
Axons Guided by Insulin Receptor in Drosophila Visual System.
J. Song, L. Wu, Z. Chen, R. A. Kohanski, and L. Pick (2003)
Science 300, 502-505
   Abstract »    Full Text »    PDF »
Insulin worms its way into the spotlight.
D. W. Nelson and R. W. Padgett (2003)
Genes & Dev. 17, 813-818
   Full Text »    PDF »
Conditional tradeoffs between aging and organismal performance of Indy long-lived mutant flies.
J. H. Marden, B. Rogina, K. L. Montooth, and S. L. Helfand (2003)
PNAS 100, 3369-3373
   Abstract »    Full Text »    PDF »
Unearthing Loci That Influence Life Span.
M. Tatar (2003)
Sci. Aging Knowl. Environ. 2003, pe5-5
   Abstract »    Full Text »
Evolutionary Medicine: From Dwarf Model Systems to Healthy Centenarians?.
V. D. Longo and C. E. Finch (2003)
Science 299, 1342-1346
   Abstract »    Full Text »    PDF »
The Endocrine Regulation of Aging by Insulin-like Signals.
M. Tatar, A. Bartke, and A. Antebi (2003)
Science 299, 1346-1351
   Abstract »    Full Text »    PDF »
Genetic Loci Modulating Fitness and Life Span in Caenorhabditis elegans: Categorical Trait Interval Mapping in CL2a x Bergerac-BO Recombinant-Inbred Worms.
S. Ayyadevara, R. Ayyadevara, A. Vertino, A. Galecki, J. J. Thaden, and R. J. S. Reis (2003)
Genetics 163, 557-570
   Abstract »    Full Text »    PDF »
Extended Longevity in Mice Lacking the Insulin Receptor in Adipose Tissue.
M. Bluher, B. B. Kahn, and C. R. Kahn (2003)
Science 299, 572-574
   Abstract »    Full Text »    PDF »
Lifelong voluntary exercise in the mouse prevents age-related alterations in gene expression in the heart.
A. M. Bronikowski, P. A. Carter, T. J. Morgan, T. Garland Jr, N. Ung, T. D. Pugh, R. Weindruch, and T. A. Prolla (2003)
Physiol Genomics 12, 129-138
   Abstract »    Full Text »    PDF »
Neuroendocrine control of a sexually dimorphic behavior by a few neurons of the pars intercerebralis in Drosophila.
Y. H. Belgacem and J.-R. Martin (2002)
PNAS 99, 15154-15158
   Abstract »    Full Text »    PDF »
Different Age-Specific Demographic Profiles Are Generated in the Same Normal-Lived Drosophila Strain by Different Longevity Stimuli.
R. Arking, J. Novoseltseva, D.-S. Hwangbo, V. Novoseltsev, and M. Lane (2002)
J. Gerontol. A Biol. Sci. Med. Sci. 57, B390-398
   Abstract »    Full Text »    PDF »
A test of evolutionary theories of aging.
K. A. Hughes, J. A. Alipaz, J. M. Drnevich, and R. M. Reynolds (2002)
PNAS 99, 14286-14291
   Abstract »    Full Text »    PDF »
Timing Requirements for Insulin/IGF-1 Signaling in C. elegans.
A. Dillin, D. K. Crawford, and C. Kenyon (2002)
Science 298, 830-834
   Abstract »    Full Text »    PDF »
Oxygen? No Thanks, I'm on a Diet.
V. D. Longo (2002)
Sci. Aging Knowl. Environ. 2002, pe10-10
   Abstract »    Full Text »
Genes, Culture, and Aging Flies--What the Lab Can and Cannot Tell Us About Natural Genetic Variation for Senescence.
C. C. Spencer and D. E. L. Promislow (2002)
Sci. Aging Knowl. Environ. 2002, pe6-6
   Abstract »    Full Text »
Structural, Biochemical, and Expression Analysis of Two Distinct Insulin-Like Growth Factor I Receptors and Their Ligands in Zebrafish.
T. Maures, S. J. Chan, B. Xu, H. Sun, J. Ding, and C. Duan (2002)
Endocrinology 143, 1858-1871
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)